Aspergillus cell wall chitin induces anti- and proinflammatory cytokines in human PBMCs via the Fc-γ receptor/Syk/PI3K pathway

mBio

Volumn 7, Issue 3, 2016, Pages

  Becker, K L ^a   Aimanianda, V ^a   Wang, Xiaowen ^a,d   Gresnigt, M S ^a   Ammerdorffer, A ^a   Jacobs, C W ^a   Gazendam, R P ^c   Joosten, L A B ^a   Netea, M G ^a   Latgé, Jean Paul ^b   van de Veerdonk, Frank L ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCAN; CHITIN; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FC RECEPTOR; IMMUNOGLOBULIN G; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MURAMYL DIPEPTIDE; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PATTERN RECOGNITION RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE SYK; TUMOR NECROSIS FACTOR ALPHA; FCGR1A PROTEIN, HUMAN; LIPOPROTEIN; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; N-PALMITOYL-S-(2,3-BIS(PALMITOYLOXY)PROPYL)CYSTEINYL-SERYL-LYSYL-LYSYL-LYSYL-LYSINE;

ARTICLE; ASPERGILLUS FUMIGATUS; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNGAL CELL WALL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; NONHUMAN; OPSONIZATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGOCYTOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; SERUM; SIGNAL TRANSDUCTION; SUPERNATANT; BIOSYNTHESIS; CELL WALL; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ASPERGILLUS FUMIGATUS; CELL WALL; CHITIN; CYTOKINES; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; LEUKOCYTES, MONONUCLEAR; LIPOPROTEINS; PATHOGEN-ASSOCIATED MOLECULAR PATTERN MOLECULES; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, IGG; SIGNAL TRANSDUCTION; SYK KINASE;

EID: 84979085233     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01823-15     Document Type: Article

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