Paracrine Engineering of Human Explant-Derived Cardiac Stem Cells to Over-Express Stromal-Cell Derived Factor 1α Enhances Myocardial Repair

Stem Cells

Volumn 34, Issue 7, 2016, Pages 1826-1835

  Tilokee, Everad L ^a   Latham, Nicholas ^a   Jackson, Robyn ^a   Mayfield, Audrey E ^a   Ye, Bin ^a   Mount, Seth ^a   Lam, Buu Khanh ^a   Suuronen, Erik J ^a   Ruel, Marc ^a   Stewart, Duncan J ^b   Davis, Darryl R ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Adult stem cells; Cardiac; SDF 1; Tissue specific stem cells

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CYTOKINE; SOMATOMEDIN C; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CARDIAC MUSCLE CELL; CARDIAC STEM CELL; CELL DIFFERENTIATION; CELL HOMING; CELL MIGRATION; CELL STIMULATION; CELL SURVIVAL; EXPLANT; GENE OVEREXPRESSION; GENE TRANSFER; HEART FUNCTION; HEART INFARCTION; HEMATOPOIESIS; MOUSE; NONHUMAN; PARACRINE SIGNALING; SIGNAL TRANSDUCTION; STEM CELL MOBILIZATION; STEM CELL TRANSPLANTATION;

EID: 84979073111     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2373     Document Type: Article

References (37)

1. Velagaleti RS, Pencina MJ, Murabito JM et al. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation 2008;118:2057–2062.
2. Beltrami AP, Barlucchi L, Torella D et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003;114:763–776.
3. Messina E, De Angelis L, Frati G et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 2004;95:911–921.
4. Smith RR, Barile L, Cho HC et al. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 2007;115:896–908.
5. Davis DR, Zhang Y, Smith RR et al. Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One 2009;4:e7195.
6. Davis DR, Kizana E, Terrovitis J et al. Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol 2010;49:312–321.
7. Davis DR, Smith RR, Marban E. Human cardiospheres are a source of stem cells with cardiomyogenic potential. Stem Cells 2010;28:903–904.
8. D'Amario D, Fiorini C, Campbell PM et al. Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. Circ Res 2011;108:857–861.
9. Latham N, Ye B, Jackson R et al. Human blood and cardiac stem cells synergize to enhance cardiac repair when cotransplanted into ischemic myocardium. Circulation 2013;128:S1-S8.
10. Molgat AS, Tilokee EL, Rafatian G et al. Hyperglycemia inhibits cardiac stem cell-mediated cardiac repair and angiogenic capacity. Circulation 2014;130:S70–S76.
11. Makkar RR, Smith RR, Cheng K et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet 2012;379:895–904.
12. Terrovitis J, LautaäSki R, Bonios M et al. Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery. J Am Coll Cardiol 2009;54:1619–1626.
13. Bonios M, Chang CY, Terrovitis J et al. Constitutive HIF-1alpha expression blunts the beneficial effects of cardiosphere-derived cell therapy in the heart by altering paracrine factor balance. J Cardiovasc Transl Res 2011;4:363–372.
14. Chimenti I, Smith RR, Li TS et al. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res 2010;106:971–980.
15. Malliaras K, Zhang Y, Seinfeld J et al. Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Mol Med 2013;5:191–209.
16. Cheng K, Malliaras K, Smith RR et al. Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair. JACC Heart Fail 2014;2:49–61.
17. Malliaras K, Ibrahim A, Tseliou E et al. Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction. EMBO Mol Med 2014;6:760–777.
18. Bearzi C, Rota M, Hosoda T et al. Human cardiac stem cells. Proc Natl Acad Sci USA 2007;104:14068–14073.
19. Mayfield AE, Tilokee EL, Latham N et al. The effect of encapsulation of cardiac stem cells within matrix-enriched hydrogel capsules on cell survival, post-ischemic cell retention and cardiac function. Biomaterials 2014;35:133–142.
20. Jackson R, Tilokee EL, Latham N et al. Paracrine engineering of human cardiac stem cells with insulin-like growth factor-1 enhances myocardial repair. J Am Heart Assoc 2015;4:e002104.
21. Ott HC, Matthiesen TS, Brechtken J et al. The adult human heart as a source for stem cells: repair strategies with embryonic-like progenitor cells. Nat Clin Pract Cardiovasc Med 2007;4(suppl 1):S27–S39.
22. Tallini YN, Greene KS, Craven M et al. c-kit expression identifies cardiovascular precursors in the neonatal heart. Proc Natl Acad Sci USA 2009;106:1808–1813.
23. Kuraitis D, Zhang P, Zhang Y et al. A stromal cell-derived factor-1 releasing matrix enhances the progenitor cell response and blood vessel growth in ischaemic skeletal muscle. Eur Cell Mater 2011;22:109–123.
24. Whitman SC, Rateri DL, Szilvassy SJ et al. Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice. Arterioscler Thromb Vasc Biol 2004;24:1049–1054.
25. Hong KU, Li QH, Guo Y et al. A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice. Basic Res Cardiol 2013;108:346.
26. Askari AT, Unzek S, Popovic ZB et al. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 2003;362:697–703.
27. Penn MS, Mendelsohn FO, Schaer GL et al. An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure. Circ Res 2013;112:816–825.
28. Cheng K, Ibrahim A, Hensley MT et al. Relative roles of CD90 and c-Kit to the regenerative efficacy of cardiosphere-derived cells in humans and in a mouse model of myocardial infarction. J Am Heart Assoc 2014;3:e001260.
29. Gago-Lopez N, Awaji O, Zhang Y et al. THY-1 receptor expression differentiates cardiosphere-derived cells with divergent cardiogenic differentiation potential. Stem Cell Rep 2014;2:576–591.
30. van Berlo JH, Kanisicak O, Maillet M et al. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature 2014;509:337–341.
31. Huber BC, Brunner S, Segeth A et al. Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+) stem cells into the ischaemic heart. Cardiovasc Res 2011;90:529–537.
32. Lee S-T, White AJ, Matsushita S et al. Direct intramyocardial injection of autologous cardiosphere-derived cells yields consistent engraftment and improves cardiac function in a porcine model of ischemic cardiomyopathy. Circulation 2009;120:S898.
33. Ibrahim AG, Cheng K, Marban E. Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Rep 2014;2:606–619.
34. Frangogiannis NG. The immune system and cardiac repair. Pharmacol Res 2008;58:88–111.
35. Flomenberg N, Devine SM, Dipersio JF et al. The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone. Blood 2005;106:1867–1874.
36. Segers VF, Tokunou T, Higgins LJ et al. Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction. Circulation 2007;116:1683–1692.
37. Theiss HD, Vallaster M, Rischpler C et al. Dual stem cell therapy after myocardial infarction acts specifically by enhanced homing via the SDF-1/CXCR4 axis. Stem Cell Res 2011;7:244–255.