Characterizing Reversible Protein Association at Moderately High Concentration Via Composition-Gradient Static Light Scattering

Journal of Pharmaceutical Sciences

Volumn 105, Issue 8, 2016, Pages 2310-2318

  Some, Daniel ^a   Pollastrini, Joseph ^b   Cao, Shawn ^b  

^a Wyatt Technology Corporation   (United States)

^b AMGEN INC   (United States)

Author keywords

biopharmaceuticals characterization; biotechnology; light scattering; protein aggregation; protein formulation; stability

Indexed keywords

BINDING AFFINITY; BIOTECHNOLOGY; EXPECTATION; PHOTON CORRELATION SPECTROSCOPY; PROTEIN AGGREGATION; SEDIMENTATION; STOICHIOMETRY; CHEMICAL MODEL; CHEMISTRY; LIGHT; PHARMACEUTICS; PROCEDURES; PROTEIN MULTIMERIZATION; RADIATION SCATTERING; SOLUTION AND SOLUBILITY; THERMODYNAMICS;

HYBRID PROTEIN; MULTIPROTEIN COMPLEX; PEPTIBODY A; PROTEIN BINDING; SODIUM CHLORIDE;

BIOPHARMACEUTICS; LIGHT; MODELS, CHEMICAL; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECOMBINANT FUSION PROTEINS; SCATTERING, RADIATION; SODIUM CHLORIDE; SOLUTIONS; THERMODYNAMICS;

EID: 84978997518     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2016.05.018     Document Type: Article

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