Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis

Development (Cambridge)

Volumn 143, Issue 7, 2016, Pages 1126-1133

  Breuss, Martin ^a   Fritz, Tanja ^a   Gstrein, Thomas ^a   Chan, Kelvin ^a,b   Ushakova, Lyubov ^a   Yu, Nuo ^a   Vonberg, Frederick W ^a,c   Werner, Barbara ^a   Elling, Ulrich ^d   Keays, David A ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Vienna Biocenter   (Austria)

Author keywords

Apoptosis; Microcephaly; Trp53; Tubulin

Indexed keywords

DNA; PROTEIN P53; TRANSCRIPTION FACTOR SOX2; TUBULIN; SOX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX; TUBB5 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL CYCLE PROGRESSION; CELL DEATH; CONTROLLED STUDY; EMBRYO; GAIN OF FUNCTION MUTATION; GENE; GENE MUTATION; GENOTYPE; IMMUNOHISTOCHEMISTRY; MICROCEPHALY; MICROTUBULE; MISSENSE MUTATION; MITOSIS SPINDLE; MOLECULAR PATHOLOGY; MOUSE; NERVE CELL; NEURAL STEM CELL; NISSL STAINING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUBB5 GENE; ABNORMALITIES; ANIMAL; BIOSYNTHESIS; BRAIN; C57BL MOUSE; CELL CYCLE; CELL DIFFERENTIATION; CYTOLOGY; DISEASE MODEL; EMBRYOLOGY; GENE TARGETING; GENETICS; KNOCKOUT MOUSE; MAMMALIAN EMBRYO; METABOLISM; SPINDLE APPARATUS; STEM CELL;

ANIMALS; APOPTOSIS; BRAIN; CELL CYCLE; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; GENE KNOCK-IN TECHNIQUES; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCEPHALY; MICROTUBULES; NEURAL STEM CELLS; SOXB1 TRANSCRIPTION FACTORS; SPINDLE APPARATUS; STEM CELLS; TUBULIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84978983216     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.131516     Document Type: Article

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