Combining biochemical with 1H NMR-based metabolomics approach unravels the antidiabetic activity of genipin and its possible mechanism

Journal of Pharmaceutical and Biomedical Analysis

Volumn 129, Issue , 2016, Pages 80-89

  Shen, Xiao li ^a   Liu, Huan ^a   Xiang, Huan ^a   Qin, Xue mei ^a   Du, Guan hua ^b   Tian, Jun sheng ^a  

^a SHANXI UNIVERSITY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antidiabetic activity; Biochemical changes; Genipin; Metabolomics; Nuclear magnetic resonance

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETIC ACID; ACETOACETIC ACID; ACETONE; ALANINE; ALLOXAN; ARGININE; CHOLESTEROL; CREATININE; FAT; GENIPIN; GLUCAGON; GLUCOSE; GLUTAMINE; GLYCOGEN; HIGH DENSITY LIPOPROTEIN; INSULIN; ISOBUTYRIC ACID; ISOLEUCINE; LACTIC ACID; LACTOSE; LEUCINE; LOW DENSITY LIPOPROTEIN; LYSINE; METFORMIN; PYRUVIC ACID; RIBOSE; TRIACYLGLYCEROL; URIC ACID; VALINE; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; IRIDOID;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BIOCHEMICAL ANALYSIS; BLOOD SAMPLING; BODY WEIGHT; CITRIC ACID CYCLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPERGLYCEMIA; LIPID METABOLISM; LOW DRUG DOSE; MALE; METABOLIC ACTIVATION; METABOLISM PARAMETERS; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; METABOLISM; METABOLOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; PROCEDURES; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; IRIDOIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; METABOLOMICS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84978969380     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2016.06.041     Document Type: Article

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