-
1
-
-
40749114497
-
Effect of interleukin- 6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a doubleblind, placebo-controlled, randomised trial
-
Smolen JS, Beaulieu A, Rubbert-Roth A et al. Effect of interleukin- 6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a doubleblind, placebo-controlled, randomised trial. Lancet 2008;371:987-97.
-
(2008)
Lancet
, vol.371
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
-
2
-
-
34447300492
-
Study of active controlled monotherapy used for rheumatoid arthritis, an IL- 6 inhibitor-evidence of clinical and radiographic benefit from an X-ray reader-blinded randomized controlled trial of tocilizumab
-
Nishimoto N, Hashimoto J, Miyasaka N et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL- 6 inhibitor-evidence of clinical and radiographic benefit from an X-ray reader-blinded randomized controlled trial of tocilizumab. Ann Rheum Dis 2007;6:1162-7.
-
(2007)
Ann Rheum Dis
, vol.6
, pp. 1162-1167
-
-
Nishimoto, N.1
Hashimoto, J.2
Miyasaka, N.3
-
3
-
-
70349402169
-
Long-term safety and efficacy of tocilizumab, an anti-IL- 6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study
-
Nishimoto N, Miyasaka N, Yamamoto K et al. Long-term safety and efficacy of tocilizumab, an anti-IL- 6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis 2009;68:1580-4.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 1580-1584
-
-
Nishimoto, N.1
Miyasaka, N.2
Yamamoto, K.3
-
4
-
-
84925549112
-
The paradigm of IL-6: from basic science to medicine
-
Naka T, Nishimoto N, Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res 2002;4 (Suppl 3):P233-42.
-
(2002)
Arthritis Res
, vol.4
, pp. P233-P242
-
-
Naka, T.1
Nishimoto, N.2
Kishimoto, T.3
-
5
-
-
33344470277
-
The definition and measurement of disease modification in inflammatory rheumatic diseases
-
Aletaha D, Smolen JS. The definition and measurement of disease modification in inflammatory rheumatic diseases. Rheum Dis Clin North Am 2006;32:9-44.
-
(2006)
Rheum Dis Clin North Am
, vol.32
, pp. 9-44
-
-
Aletaha, D.1
Smolen, J.S.2
-
6
-
-
78650764821
-
Interleukin- 6 receptor inhibition with tocilizumab and attainment of disease remission in rheumatoid arthritis: the role of acute-phase reactants
-
Smolen J, Aletaha D. Interleukin- 6 receptor inhibition with tocilizumab and attainment of disease remission in rheumatoid arthritis: the role of acute-phase reactants. Arthritis Rheum 2011;63:43-52.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 43-52
-
-
Smolen, J.1
Aletaha, D.2
-
8
-
-
0342905417
-
The regulatory role of MRP8 (S100A8) and MRP 14 (S100A9) in the transendothelial migration of human leukocytes
-
Kerkhoff C, Eue I, Sorg C. The regulatory role of MRP8 (S100A8) and MRP 14 (S100A9) in the transendothelial migration of human leukocytes. Pathobiology 1999;67:230-2.
-
(1999)
Pathobiology
, vol.67
, pp. 230-232
-
-
Kerkhoff, C.1
Eue, I.2
Sorg, C.3
-
9
-
-
0025730099
-
The leukocyte protein L 1 in plasma and synovial fluid from patients with rheumatoid arthritis and osteoarthritis
-
Berntzen HB, Ölmez Ü, Fagerhol MK et al. The leukocyte protein L 1 in plasma and synovial fluid from patients with rheumatoid arthritis and osteoarthritis. Scand J Rheumatol 1991,20:74-82.
-
(1991)
Scand J Rheumatol
, vol.20
, pp. 74-82
-
-
Berntzen, H.B.1
Ölmez, Ü.2
Fagerhol, M.K.3
-
10
-
-
0024852024
-
A longitudinal study of the leukocyte protein L 1 as an indicator of disease activity in patients with rheumatoid arthritis
-
Berntzen HB, Munthe E, Fagerhol MK. A longitudinal study of the leukocyte protein L 1 as an indicator of disease activity in patients with rheumatoid arthritis. J Rheumatol 1989;16:1416-20.
-
(1989)
J Rheumatol
, vol.16
, pp. 1416-1420
-
-
Berntzen, H.B.1
Munthe, E.2
Fagerhol, M.K.3
-
11
-
-
54949150604
-
Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs
-
Genovese MC, McKay JD, Nasonov EL et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum (2008);58:2968-80.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2968-2980
-
-
Genovese, M.C.1
McKay, J.D.2
Nasonov, E.L.3
-
12
-
-
83255162593
-
Disease activity score 28 may overestimate the remission induction of rheumatoid arthritis patients treated with tocilizumab: comparison with the remission by the clinical disease activity index
-
Kawashiri SY, Kawakami A, Iwamoto N et al. Disease activity score 28 may overestimate the remission induction of rheumatoid arthritis patients treated with tocilizumab: comparison with the remission by the clinical disease activity index. Mod Rheumatol 2011;21:365-9.
-
(2011)
Mod Rheumatol
, vol.21
, pp. 365-369
-
-
Kawashiri, S.Y.1
Kawakami, A.2
Iwamoto, N.3
-
13
-
-
34547228744
-
Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis
-
Hammer HB, Odegard S, Fagerhol MK et al. Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis. Ann Rheum Dis 2007;66:1093-7.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 1093-1097
-
-
Hammer, H.B.1
Odegard, S.2
Fagerhol, M.K.3
-
14
-
-
84983179003
-
Serum calprotectin as marker for disease activity and severity in adult-onset Still's disease
-
Sang-Youn J, Young-Beon P, You-Jung H et al. Serum calprotectin as marker for disease activity and severity in adult-onset Still's disease. J Rheumatol 2010;37:5.
-
(2010)
J Rheumatol
, vol.37
, pp. 5
-
-
Sang-Youn, J.1
Young-Beon, P.2
You-Jung, H.3
-
15
-
-
84880578156
-
A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/ 14 protein
-
Moncrieffe H, Ursu S, Holzinger D et al. A subgroup of juvenile idiopathic arthritis patients who respond well to methotrexate are identified by the serum biomarker MRP8/ 14 protein. Rheumatology 2013;52:1467-76.
-
(2013)
Rheumatology
, vol.52
, pp. 1467-1476
-
-
Moncrieffe, H.1
Ursu, S.2
Holzinger, D.3
-
16
-
-
84901811484
-
S-Calprotectin (S100A8/S100A9): a potential marker of inflammation in patients with psoriatic arthritis
-
Hansson C, Eriksson C, Alenius G-M. S-Calprotectin (S100A8/S100A9): a potential marker of inflammation in patients with psoriatic arthritis. J Immunol Res 2014;2014:696415.
-
(2014)
J Immunol Res
, vol.2014
, pp. 696415
-
-
Hansson, C.1
Eriksson, C.2
Alenius, G.-M.3
-
17
-
-
83455210182
-
The soluble biomarker calprotectin (a S 100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab
-
Hammer HB, Fagerho MK, Wien TN et al. The soluble biomarker calprotectin (a S 100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab. Arthritis Res Ther 2011;13:R178.
-
(2011)
Arthritis Res Ther
, vol.13
, pp. R178
-
-
Hammer, H.B.1
Fagerho, M.K.2
Wien, T.N.3
-
18
-
-
73449083779
-
Calprotectin (a major S 100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis
-
Hammer HB, Ødegård S, Syversen SW et al. Calprotectin (a major S 100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis. Ann Rheum Dis 2010;69:150-4.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 150-154
-
-
Hammer, H.B.1
Ødegård, S.2
Syversen, S.W.3
-
19
-
-
84983147209
-
-
( 25 August, date last accessed)
-
Pharmaceuticals and Medical Devices Agency Report of Deliberation Results for Actemra 2008. http://www.pmda. go.jp/english/service/pdf/actemra.pdf ( 25 August 2014, date last accessed).
-
(2014)
-
-
-
20
-
-
0038166958
-
Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study
-
Nishimoto N, Yoshizaki K, Maeda K et al. Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study. J Rheumatol 2003;30:1426-35.
-
(2003)
J Rheumatol
, vol.30
, pp. 1426-1435
-
-
Nishimoto, N.1
Yoshizaki, K.2
Maeda, K.3
|