Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling

International Journal of Molecular Medicine

Volumn 38, Issue 2, 2016, Pages 619-626

  Shen, Xinsheng ^a   Si, Yaqing ^a   Wang, Zhao ^a   Wang, Jiachen ^a   Guo, Yongqiang ^a   Zhang, Xiefu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Cell growth; Gastric cancer stem cells; Mitochondria; Phosphoinositide 3 kinase Akt; Quercetin

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; QUERCETIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CANCER STEM CELL; CELL SEPARATION; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MITOCHONDRION; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SEPARATION; CELL SURVIVAL; HUMANS; MITOCHONDRIA; NEOPLASTIC STEM CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; QUERCETIN; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 84978906118     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2016.2625     Document Type: Article

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