Nano-encapsulated chlorophyllin significantly delays progression of lung cancer both in in vitro and in vivo models through activation of mitochondrial signaling cascades and drug-DNA interaction

Environmental Toxicology and Pharmacology

Volumn 46, Issue , 2016, Pages 147-157

  Das, Jayeeta ^a   Samadder, Asmita ^b,c   Mondal, Jesmin ^a   Abraham, Suresh K ^b   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c Dum Dum Motijheel College   (India)

Author keywords

A549 cells; Anti cancer efficacy; Chlorophyllin; Mice; Mitochondrial signaling; Poly (lactic co glycolic) acid

Indexed keywords

ARSENITE SODIUM; BENZO[A]PYRENE; CASPASE 3; CHLOROPHYLL; CYTOCHROME C; DNA; POLYGLACTIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CALF THYMUS DNA; CHLOROPHYLLIDE; LACTIC ACID; NANOMATERIAL; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

A549 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOMIC FORCE MICROSCOPY; BLOOD BRAIN BARRIER; CALF (BOVINE); CANCER CELL; CELL VIABILITY; CHROMOSOME ABERRATION; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONFORMATION; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG TARGETING; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MICRONUCLEUS; MOUSE; NANOENCAPSULATION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMUS; TISSUE INJURY; ULTRAVIOLET SPECTROSCOPY; ANIMAL; BAGG ALBINO MOUSE; CARCINOMA, NON-SMALL-CELL LUNG; CHEMISTRY; DRUG EFFECTS; GENETICS; LUNG NEOPLASMS; METABOLISM; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CHLOROPHYLLIDES; CHROMOSOME ABERRATIONS; CIRCULAR DICHROISM; CYTOCHROMES C; DNA; HUMANS; LACTIC ACID; LUNG NEOPLASMS; MICE, INBRED BALB C; MITOCHONDRIA; NANOSTRUCTURES; POLYGLYCOLIC ACID; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84978819044     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2016.07.006     Document Type: Article

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