TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis

Nature

Volumn 535, Issue 7611, 2016, Pages 303-307

  Hsieh, Joanne ^a   Koseki, Masahiro ^a,b   Molusky, Matthew M ^a   Yakushiji, Emi ^a   Ichi, Ikuyo ^c   Westerterp, Marit ^a   Iqbal, Jahangir ^d   Chan, Robin B ^e   Abramowicz, Sandra ^a   Tascau, Liana ^a   Takiguchi, Shunichi ^f,g   Yamashita, Shizuya ^b   Welch, Carrie L ^a   Di Paolo, Gilbert ^e   Hussain, M Mahmood ^d   Lefkowitch, Jay H ^e   Rader, Daniel J ^f,g   Tall, Alan R ^a  

^a Columbia University ^*  (United States)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OCHANOMIZU UNIVERSITY   (Japan)

^d SUNY DOWNSTATE MEDICAL CENTER   (United States)

^e Department of Medicine   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOSPHATIDYLCHOLINE; POLYUNSATURATED FATTY ACID; TETRATRICOPEPTIDE REPEAT DOMAIN PROTEIN 39B; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABC TRANSPORTER G5; ABC TRANSPORTER G8; ABCA1 PROTEIN, MOUSE; ABCG5 PROTEIN, MOUSE; ABCG8 PROTEIN, MOUSE; BILE ACID; CHOLESTEROL INTAKE; LIGAND; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; NR1H3 PROTEIN, HUMAN; NR1H3 PROTEIN, MOUSE; ORPHAN NUCLEAR RECEPTOR; SREBF1 PROTEIN, MOUSE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TTC39B PROTEIN, MOUSE; UNSATURATED FATTY ACID;

BLOOD SYSTEM DISORDER; DIET; DIGESTIVE SYSTEM DISORDER; FATTY ACID; GENE EXPRESSION; INHIBITION; PHOSPHOLIPID; PROTEIN; STEROL; WESTERN WORLD;

ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL INTAKE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UBIQUITINATION; ANIMAL; BIOSYNTHESIS; DEFICIENCY; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LIPID DIET; LIPOGENESIS; LIVER CELL; MALE; METABOLISM; PROTEIN STABILITY;

MUS;

ANIMALS; ATHEROSCLEROSIS; ATP BINDING CASSETTE TRANSPORTER 1; ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY G, MEMBER 5; ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY G, MEMBER 8; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; CHOLESTEROL, DIETARY; CHOLESTEROL, HDL; DIET, HIGH-FAT; FATTY ACIDS, UNSATURATED; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION; HEPATOCYTES; LIGANDS; LIPOGENESIS; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LIVER X RECEPTORS; MALE; MICE; ORPHAN NUCLEAR RECEPTORS; PHOSPHATIDYLCHOLINES; PROTEIN STABILITY; PROTEOLYSIS; RECEPTORS, LDL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UBIQUITINATION;

EID: 84978763806     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18628     Document Type: Article

References (38)

1. Musso, G., Gambino, R., Cassader, M., Pagano, G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 52, 79-104 (2010).
2. Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010).
3. Willer, C. J. et al. Discovery and refinement of loci associated with lipid levels. Nature Genet. 45, 1274-1283 (2013).
4. McNeish, J. et al. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc. Natl Acad. Sci. USA 97, 4245-4250 (2000).
5. Brunham, L. R. et al. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J. Clin. Invest. 116, 1052-1062 (2006).
6. Wu, A. L., Windmueller, H. G. Relative contributions by liver and intestine to individual plasma apolipoproteins in the rat. J. Biol. Chem. 254, 7316-7322 (1979).
7. Costet, P., Luo, Y., Wang, N., Tall, A. R. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol. Chem. 275, 28240-28245 (2000).
8. Zelcer, N., Hong, C., Boyadjian, R., Tontonoz, P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325, 100-104 (2009).
9. Matsuzawa, N. et al. Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology 46, 1392-1403 (2007).
10. Rong, X. et al. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 18, 685-697 (2013).
11. Bensinger, S. J. et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134, 97-111 (2008).
12. Lo Sasso, G. et al. Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis. Cell Metab. 12, 187-193 (2010).
13. Zhang, Y. et al. Liver LXR? expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J. Clin. Invest. 122, 1688-1699 (2012).
14. Yu, L. et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J. Clin. Invest. 110, 671-680 (2002).
15. Repa, J. J. et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR? and LXR? . Genes Dev. 14, 2819-2830 (2000).
16. Hegarty, B. D. et al. Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc. Natl Acad. Sci. USA 102, 791-796 (2005).
17. Huang, Y. et al. A feed-forward loop amplifies nutritional regulation of PNPLA3. Proc. Natl Acad. Sci. USA 107, 7892-7897 (2010).
18. Romeo, S. et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nature Genet. 40, 1461-1465 (2008).
19. Vatner, D. F. et al. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. Proc. Natl Acad. Sci. USA 112, 1143-1148 (2015).
20. Walker, A. K. et al. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 147, 840-852 (2011).
21. Hishikawa, D. et al. Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl Acad. Sci. USA 105, 2830-2835 (2008).
22. Rong, X. et al. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. eLife 4, http://dx.doi.org/10.7554/eLife.06557 (2015).
23. Hannah, V. C., Ou, J., Luong, A., Goldstein, J. L., Brown, M. S. Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells. J. Biol. Chem. 276, 4365-4372 (2001).
24. Kammoun, H. L. et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J. Clin. Invest. 119, 1201-1215 (2009).
25. Boergesen, M. et al. Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor ? in mouse liver reveals extensive sharing of binding sites. Mol. Cell. Biol. 32, 852-867 (2012).
26. Lehrke, M. et al. Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXR? . Cell Metab. 1, 297-308 (2005).
27. Perreault, N., Beaulieu, J. F. Primary cultures of fully differentiated and pure human intestinal epithelial cells. Exp. Cell Res. 245, 34-42 (1998).
28. Anwar, K., Iqbal, J., Hussain, M. M. Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. J. Lipid Res. 48, 2028-2038 (2007).
29. Iqbal, J., Anwar, K., Hussain, M. M. Multiple, independently regulated pathways of cholesterol transport across the intestinal epithelial cells. J. Biol. Chem. 278, 31610-31620 (2003).
30. Kleiner, D. E. et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41, 1313-1321 (2005).
31. Tomoyori, H. et al. Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but do not accelerate atherosclerosis in apolipoprotein E-deficient mice. J. Nutr. 134, 1690-1696 (2004).
32. Bligh, E. G., Dyer, W. J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917 (1959).
33. Dzeletovic, S., Breuer, O., Lund, E., Diczfalusy, U. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal. Biochem. 225, 73-80 (1995).
34. Spady, D. K., Dietschy, J. M. Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat. J. Lipid Res. 24, 303-315 (1983).
35. Chan, R. B. et al. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J. Biol. Chem. 287, 2678-2688 (2012).
36. Stary, H. C. et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 92, 1355-1374 (1995).
37. Gijbels, M. J. et al. Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice: an immunohistochemical study. Atherosclerosis 143, 15-25 (1999).
38. Collins, J. L. et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J. Med. Chem. 45, 1963-1966 (2002).