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Volumn 47, Issue 4, 2015, Pages 341-348

Increased apolipoprotein A5 expression in human and rat non-alcoholic fatty livers

Author keywords

apoA5; NAFLD; NASH; perilipin; triglyceride

Indexed keywords

APOA5 PROTEIN, HUMAN; APOA5 PROTEIN, RAT; APOLIPOPROTEIN; APOLIPOPROTEIN A; APOLIPOPROTEIN A5;

EID: 84978761875     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0000000000000251     Document Type: Article
Times cited : (22)

References (51)
  • 1
    • 12944295219 scopus 로고    scopus 로고
    • The novel apolipoprotein A5 is presentin human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipo-proteins
    • 1. O'Brien, P.J., Alborn, W.E., Sloan, J.H., et al. The novel apolipoprotein A5 is presentin human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipo-proteins. Clin Chem 51 (2005), 351–359.
    • (2005) Clin Chem , vol.51 , pp. 351-359
    • O'Brien, P.J.1    Alborn, W.E.2    Sloan, J.H.3
  • 2
    • 0035812707 scopus 로고    scopus 로고
    • An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
    • 2. Pennacchio, L.A., Olivier, M., Hubacek, J.A., et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science 294 (2001), 169–173.
    • (2001) Science , vol.294 , pp. 169-173
    • Pennacchio, L.A.1    Olivier, M.2    Hubacek, J.A.3
  • 3
    • 21844445574 scopus 로고    scopus 로고
    • Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism
    • 3. Lookene, A., Beckstead, J.A., Nilsson, S., et al. Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism. J Biol Chem 280 (2005), 25383–25387.
    • (2005) J Biol Chem , vol.280 , pp. 25383-25387
    • Lookene, A.1    Beckstead, J.A.2    Nilsson, S.3
  • 4
    • 78650419569 scopus 로고    scopus 로고
    • Intravenous injection of apoli-poprotein A-V reconstituted high-density lipoprotein decreases hypertri-glyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1
    • 4. Shu, X., Nelbach, L., Weinstein, M.M., et al. Intravenous injection of apoli-poprotein A-V reconstituted high-density lipoprotein decreases hypertri-glyceridemia in apoav-/- mice and requires glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1. Arterioscler Thromb Vasc Biol 30 (2010), 2504–2509.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2504-2509
    • Shu, X.1    Nelbach, L.2    Weinstein, M.M.3
  • 5
    • 3142581525 scopus 로고    scopus 로고
    • ApoAV reduces plasma triglycer-ides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis
    • 5. Schaap, F.G., Rensen, P.C., Voshol, P.J., et al. ApoAV reduces plasma triglycer-ides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis. J Biol Chem 279 (2004), 27941–27947.
    • (2004) J Biol Chem , vol.279 , pp. 27941-27947
    • Schaap, F.G.1    Rensen, P.C.2    Voshol, P.J.3
  • 6
    • 77649336543 scopus 로고
    • Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation
    • 6. Shu, X., Nelbach, L., Ryan, R.O., et al. Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation. Bio-chim Biophys Acta 2010 (1801), 605–608.
    • (1801) Bio-chim Biophys Acta , vol.2010 , pp. 605-608
    • Shu, X.1    Nelbach, L.2    Ryan, R.O.3
  • 7
    • 78751510143 scopus 로고    scopus 로고
    • Biogenesis of apolipoprotein A-V and its impact on VLDL triglyceride secretion
    • 7. Blade, A.M., Fabritius, M.A., Hou, L., et al. Biogenesis of apolipoprotein A-V and its impact on VLDL triglyceride secretion. J Lipid Res 52 (2011), 237–244.
    • (2011) J Lipid Res , vol.52 , pp. 237-244
    • Blade, A.M.1    Fabritius, M.A.2    Hou, L.3
  • 8
    • 34548154320 scopus 로고    scopus 로고
    • Apolipoprotein A-V association with intracellular lipid droplets
    • 8. Shu, X., Chan, J., Ryan, R.O., et al. Apolipoprotein A-V association with intracellular lipid droplets. J Lipid Res 48 (2007), 1445–1450.
    • (2007) J Lipid Res , vol.48 , pp. 1445-1450
    • Shu, X.1    Chan, J.2    Ryan, R.O.3
  • 9
    • 51449118230 scopus 로고    scopus 로고
    • Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment
    • 9. Shu, X., Ryan, R.O., Forte, TM., Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment. J Lipid Res 49 (2008), 1670–1676.
    • (2008) J Lipid Res , vol.49 , pp. 1670-1676
    • Shu, X.1    Ryan, R.O.2    Forte, T.M.3
  • 10
    • 0035977037 scopus 로고    scopus 로고
    • Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration
    • 10. van der Vliet, H.N., Sammels, M.G., Leegwater, A.C., et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J Biol Chem 276 (2001), 44512–44520.
    • (2001) J Biol Chem , vol.276 , pp. 44512-44520
    • van der Vliet, H.N.1    Sammels, M.G.2    Leegwater, A.C.3
  • 11
    • 0025820155 scopus 로고
    • Biosynthesis and secretion of triacylglycerol in rat liver after partial hepatectomy
    • 11. Tijburg, L.B., Nyathi, C.B., Meijer, G.W., et al. Biosynthesis and secretion of triacylglycerol in rat liver after partial hepatectomy. J Biol Chem 277 (1991), 723–728.
    • (1991) J Biol Chem , vol.277 , pp. 723-728
    • Tijburg, L.B.1    Nyathi, C.B.2    Meijer, G.W.3
  • 12
    • 10644240816 scopus 로고    scopus 로고
    • Probing Prometheus: fat fueling the fire?
    • 12. Farrell, GC., Probing Prometheus: fat fueling the fire?. Hepatology 40 (2004), 1252–1255.
    • (2004) Hepatology , vol.40 , pp. 1252-1255
    • Farrell, G.C.1
  • 13
    • 1842864853 scopus 로고    scopus 로고
    • Two independent apolipo-protein A5 haplotypes influence human plasma triglyceride levels
    • 13. Pennacchio, L.A., Olivier, M., Hubacek, J.A., et al. Two independent apolipo-protein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet 11 (2002), 3031–3038.
    • (2002) Hum Mol Genet , vol.11 , pp. 3031-3038
    • Pennacchio, L.A.1    Olivier, M.2    Hubacek, J.A.3
  • 14
    • 49649105016 scopus 로고
    • The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels
    • 14. Palmen, J., Smith, A.J., Dorfmeister, B., et al. The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels. Biochim Biophys Acta 2008 (1782), 447–452.
    • (1782) Biochim Biophys Acta , vol.2008 , pp. 447-452
    • Palmen, J.1    Smith, A.J.2    Dorfmeister, B.3
  • 15
    • 23344440871 scopus 로고    scopus 로고
    • Determination of the functionality of common APOA5 polymorphisms
    • 15. Talmud, P.J., Palmen, J., Putt, W., et al. Determination of the functionality of common APOA5 polymorphisms. J Biol Chem 280 (2005), 28215–28220.
    • (2005) J Biol Chem , vol.280 , pp. 28215-28220
    • Talmud, P.J.1    Palmen, J.2    Putt, W.3
  • 16
    • 51449114710 scopus 로고    scopus 로고
    • An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients
    • 16. Pullinger, C.R., Aouizerat, B.E., Movsesyan, I., et al. An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients. J Lipid Res 49 (2008), 1846–1854.
    • (2008) J Lipid Res , vol.49 , pp. 1846-1854
    • Pullinger, C.R.1    Aouizerat, B.E.2    Movsesyan, I.3
  • 17
    • 19944431083 scopus 로고    scopus 로고
    • Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia
    • 17. Priore Oliva, C., Pisciotta, L., Li Volti, G., et al. Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia. Arterioscler Thromb Vasc Biol 25 (2005), 411–417.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 411-417
    • Priore Oliva, C.1    Pisciotta, L.2    Li Volti, G.3
  • 18
    • 84893833662 scopus 로고    scopus 로고
    • Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
    • 18. Albers, K., Schlein, C., Wenner, K., et al. Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant. Atherosclerosis 233 (2014), 97–103.
    • (2014) Atherosclerosis , vol.233 , pp. 97-103
    • Albers, K.1    Schlein, C.2    Wenner, K.3
  • 19
    • 84896690513 scopus 로고    scopus 로고
    • Prevalence of childhood and adult obesity in the United States
    • 19. Ogden, C.L., Carroll, M.D., Kit, B.K., et al. Prevalence of childhood and adult obesity in the United States. JAMA 311 (2014), 806–814.
    • (2014) JAMA , vol.311 , pp. 806-814
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3
  • 20
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
    • 20. Williams, C.D., Stengel, J., Asike, M.I., et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 140 (2011), 124–131.
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3
  • 21
    • 84874645372 scopus 로고    scopus 로고
    • Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988–1994 to 2007–2010
    • 21. Welsh, J.A., Karpen, S., Vos, MB., Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988–1994 to 2007–2010. J Pediatr 162 (2013), 2007–2010.
    • (2013) J Pediatr , vol.162 , pp. 2007-2010
    • Welsh, J.A.1    Karpen, S.2    Vos, M.B.3
  • 22
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • 22. Kleiner, D.E., Brunt, E.M., Van Natta, M., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005), 1313–1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 23
    • 79958212809 scopus 로고    scopus 로고
    • The role of apolipoprotein A5 in non-alcoholic fatty liver disease
    • 23. Ress, C., Moschen, A.R., Sausgruber, N., et al. The role of apolipoprotein A5 in non-alcoholic fatty liver disease. Gut 60 (2011), 985–991.
    • (2011) Gut , vol.60 , pp. 985-991
    • Ress, C.1    Moschen, A.R.2    Sausgruber, N.3
  • 24
    • 77949677097 scopus 로고    scopus 로고
    • Role of alcohol metabolism in nonalcoholic steatohepatitis
    • 24. Baker, S.S., Baker, R.D., Liu, W., et al. Role of alcohol metabolism in nonalcoholic steatohepatitis. PLoS One, 5, 2010, e9570.
    • (2010) PLoS One , vol.5 , pp. e9570
    • Baker, S.S.1    Baker, R.D.2    Liu, W.3
  • 25
    • 80052637451 scopus 로고    scopus 로고
    • Upregulation of hemoglobin expression by oxidative stress in hepatocytes and its implication in nonalcoholic steatohepatitis
    • 25. Liu, W., Baker, S.S., Baker, R.D., et al. Upregulation of hemoglobin expression by oxidative stress in hepatocytes and its implication in nonalcoholic steatohepatitis. PLoS One, 6, 2011, e24363.
    • (2011) PLoS One , vol.6 , pp. e24363
    • Liu, W.1    Baker, S.S.2    Baker, R.D.3
  • 26
    • 79959336013 scopus 로고    scopus 로고
    • Lipid in the livers of adolescents with nonalcoholic steatohepatitis: combined effects of pathways on steatosis
    • 26. Zhu, L., Baker, S.S., Liu, W., et al. Lipid in the livers of adolescents with nonalcoholic steatohepatitis: combined effects of pathways on steatosis. Metabolism 60 (2011), 1001–1011.
    • (2011) Metabolism , vol.60 , pp. 1001-1011
    • Zhu, L.1    Baker, S.S.2    Liu, W.3
  • 28
    • 84890129317 scopus 로고    scopus 로고
    • Paraoxonase 1 and oxidative stress in paediatric non-alcoholic steatohepatitis
    • 28. Desai, S., Baker, S.S., Liu, W., et al. Paraoxonase 1 and oxidative stress in paediatric non-alcoholic steatohepatitis. Liver Int 34 (2014), 110–117.
    • (2014) Liver Int , vol.34 , pp. 110-117
    • Desai, S.1    Baker, S.S.2    Liu, W.3
  • 29
    • 84859354773 scopus 로고    scopus 로고
    • Effect of dietary advanced glycation end products on mouse liver
    • 29. Patel, R., Baker, S.S., Liu, W., et al. Effect of dietary advanced glycation end products on mouse liver. PLoS One, 7, 2012, e35143.
    • (2012) PLoS One , vol.7 , pp. e35143
    • Patel, R.1    Baker, S.S.2    Liu, W.3
  • 30
    • 33845493476 scopus 로고    scopus 로고
    • Prevalence and determinants of insulin resistance among US adolescents: a population-based study
    • 30. Lee, J.M., Okumura, M.J., Davis, M.M., et al. Prevalence and determinants of insulin resistance among US adolescents: a population-based study. Diabetes Care 29 (2006), 2427–2432.
    • (2006) Diabetes Care , vol.29 , pp. 2427-2432
    • Lee, J.M.1    Okumura, M.J.2    Davis, M.M.3
  • 31
    • 46249097997 scopus 로고    scopus 로고
    • Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steato-genesis
    • 31. Straub, B.K., Stoeffel, P., Heid, H., et al. Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steato-genesis. Hepatology 47 (2008), 1936–1946.
    • (2008) Hepatology , vol.47 , pp. 1936-1946
    • Straub, B.K.1    Stoeffel, P.2    Heid, H.3
  • 32
    • 66349097499 scopus 로고    scopus 로고
    • The ins (cell) and outs (plasma) of apolipoprotein A-V
    • (Suppl)
    • 32. Forte, T.M., Shu, X., Ryan, R.O., The ins (cell) and outs (plasma) of apolipoprotein A-V. J Lipid Res 50 (2009), S150–S155 (Suppl).
    • (2009) J Lipid Res , vol.50 , pp. S150-S155
    • Forte, T.M.1    Shu, X.2    Ryan, R.O.3
  • 33
    • 20144375048 scopus 로고    scopus 로고
    • Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
    • 33. Merkel, M., Loeffler, B., Kluger, M., et al. Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase. J Biol Chem 280 (2005), 21553–21560.
    • (2005) J Biol Chem , vol.280 , pp. 21553-21560
    • Merkel, M.1    Loeffler, B.2    Kluger, M.3
  • 34
    • 33947706206 scopus 로고    scopus 로고
    • Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family
    • 34. Nilsson, S.K., Lookene, A., Beckstead, J.A., et al. Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family. Biochemistry 46 (2007), 3896–3904.
    • (2007) Biochemistry , vol.46 , pp. 3896-3904
    • Nilsson, S.K.1    Lookene, A.2    Beckstead, J.A.3
  • 35
    • 0036349314 scopus 로고    scopus 로고
    • Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice
    • 35. van der Vliet, H.N., Schaap, F.G., Levels, J.H., et al. Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. Biochem Biophys Res Commun 295 (2002), 1156–1159.
    • (2002) Biochem Biophys Res Commun , vol.295 , pp. 1156-1159
    • van der Vliet, H.N.1    Schaap, F.G.2    Levels, J.H.3
  • 36
    • 2642532678 scopus 로고    scopus 로고
    • Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5
    • 36. Fruchart-Najib, J., Bauge, E., Niculescu, L.S., et al. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem Biophys Res Commun 319 (2004), 397–404.
    • (2004) Biochem Biophys Res Commun , vol.319 , pp. 397-404
    • Fruchart-Najib, J.1    Bauge, E.2    Niculescu, L.S.3
  • 37
    • 3042817124 scopus 로고    scopus 로고
    • Analysis of apolipoprotein A5, c3, and plasma triglyceride concentrations in genetically engineered mice
    • 37. Baroukh, N., Bauge, E., Akiyama, J., et al. Analysis of apolipoprotein A5, c3, and plasma triglyceride concentrations in genetically engineered mice. Arterioscler Thromb Vasc Biol 24 (2004), 1297–1302.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1297-1302
    • Baroukh, N.1    Bauge, E.2    Akiyama, J.3
  • 38
    • 33744922097 scopus 로고    scopus 로고
    • Plasma apolipoprotein A5 and triglycerides in type 2 diabetes
    • 38. Dallinga-Thie, G.M., van Tol, A., Hattori, H., et al. Plasma apolipoprotein A5 and triglycerides in type 2 diabetes. Diabetologia 49 (2006), 1505–1511.
    • (2006) Diabetologia , vol.49 , pp. 1505-1511
    • Dallinga-Thie, G.M.1    van Tol, A.2    Hattori, H.3
  • 39
    • 33748507076 scopus 로고    scopus 로고
    • The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II
    • 39. Talmud, P.J., Cooper, J.A., Hattori, H., et al. The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II. Diabetologia 49 (2006), 2337–2340.
    • (2006) Diabetologia , vol.49 , pp. 2337-2340
    • Talmud, P.J.1    Cooper, J.A.2    Hattori, H.3
  • 40
    • 33748747407 scopus 로고    scopus 로고
    • Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study
    • 40. Vaessen, S.F., Schaap, F.G., Kuivenhoven, J.A., et al. Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. J Lipid Res 47 (2006), 2064–2070.
    • (2006) J Lipid Res , vol.47 , pp. 2064-2070
    • Vaessen, S.F.1    Schaap, F.G.2    Kuivenhoven, J.A.3
  • 41
    • 34248666075 scopus 로고    scopus 로고
    • Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism
    • 41. Henneman, P., Schaap, F.G., Havekes, L.M., et al. Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism. Atherosclerosis 193 (2007), 129–134.
    • (2007) Atherosclerosis , vol.193 , pp. 129-134
    • Henneman, P.1    Schaap, F.G.2    Havekes, L.M.3
  • 42
    • 23044515047 scopus 로고    scopus 로고
    • Thyroid hormone regulates the hypo-triglyceridemic gene APOA5
    • 42. Prieur, X., Huby, T., Coste, H., et al. Thyroid hormone regulates the hypo-triglyceridemic gene APOA5. J Biol Chem 280 (2005), 27533–27534.
    • (2005) J Biol Chem , vol.280 , pp. 27533-27534
    • Prieur, X.1    Huby, T.2    Coste, H.3
  • 43
    • 20144379880 scopus 로고    scopus 로고
    • Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha
    • 43. Genoux, A., Dehondt, H., Helleboid-Chapman, A., et al. Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha. Arterioscler Thromb Vasc Biol 25 (2005), 1186–1192.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1186-1192
    • Genoux, A.1    Dehondt, H.2    Helleboid-Chapman, A.3
  • 44
    • 13444256227 scopus 로고    scopus 로고
    • Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidy-linositol 3-kinase pathway: role of upstream stimulatory factor
    • 44. Nowak, M., Helleboid-Chapman, A., Jakel, H., et al. Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidy-linositol 3-kinase pathway: role of upstream stimulatory factor. Mol Cell Biol 25 (2005), 1537–1548.
    • (2005) Mol Cell Biol , vol.25 , pp. 1537-1548
    • Nowak, M.1    Helleboid-Chapman, A.2    Jakel, H.3
  • 45
    • 8544267260 scopus 로고    scopus 로고
    • The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c
    • 45. Jakel, H., Nowak, M., Moitrot, E., et al. The liver X receptor ligand T0901317 down-regulates APOA5 gene expression through activation of SREBP-1c. J Biol Chem 279 (2004), 45462–45469.
    • (2004) J Biol Chem , vol.279 , pp. 45462-45469
    • Jakel, H.1    Nowak, M.2    Moitrot, E.3
  • 46
    • 0032717958 scopus 로고    scopus 로고
    • Hyperinsulinemia and insulin resistance in non-alcoholic steatohepatitis
    • 46. Tankurt, E., Biberoglu, S., Ellidokuz, E., et al. Hyperinsulinemia and insulin resistance in non-alcoholic steatohepatitis. J Hepatol, 31, 1999, 963.
    • (1999) J Hepatol , vol.31 , pp. 963
    • Tankurt, E.1    Biberoglu, S.2    Ellidokuz, E.3
  • 47
    • 17244368548 scopus 로고    scopus 로고
    • Insulin resistance in NASH
    • 47. Choudhury, J., Sanyal, AJ., Insulin resistance in NASH. Frontiers Biosci 10 (2005), 1520–1533.
    • (2005) Frontiers Biosci , vol.10 , pp. 1520-1533
    • Choudhury, J.1    Sanyal, A.J.2
  • 48
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • 48. Samuel, V.T., Liu, Z.X., Qu, X., et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279 (2004), 32345–32353.
    • (2004) J Biol Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3
  • 49
    • 84903954886 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and thyroid dysfunction: A systematic review
    • 49. Eshraghian, A., Hamidian Jahromi, A., Non-alcoholic fatty liver disease and thyroid dysfunction: A systematic review. World J Gastroenterol 20 (2014), 8102–8109.
    • (2014) World J Gastroenterol , vol.20 , pp. 8102-8109
    • Eshraghian, A.1    Hamidian Jahromi, A.2
  • 50
    • 79960416891 scopus 로고    scopus 로고
    • Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis
    • 50. Kang, H.S., Okamoto, K., Takeda, Y., et al. Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiol Genomics 43 (2011), 818–828.
    • (2011) Physiol Genomics , vol.43 , pp. 818-828
    • Kang, H.S.1    Okamoto, K.2    Takeda, Y.3
  • 51
    • 79251639639 scopus 로고    scopus 로고
    • Enhanced expression of pro-inflammatory mediators and liver X-recep-tor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis
    • 51. Lima-Cabello, E., Garcia-Mediavilla, M.V., Miquilena-Colina, M.E., et al. Enhanced expression of pro-inflammatory mediators and liver X-recep-tor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis. C. Clin Sci 120 (2011), 239–250.
    • (2011) C. Clin Sci , vol.120 , pp. 239-250
    • Lima-Cabello, E.1    Garcia-Mediavilla, M.V.2    Miquilena-Colina, M.E.3


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