Apolipoprotein A-V association with intracellular lipid droplets

Journal of Lipid Research

Volumn 48, Issue 7, 2007, Pages 1445-1450

  Shu, Xiao ^a,b   Chan, Joanne ^a   Ryan, Robert O ^a,b   Forte, Trudy M ^a  

^a CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apolipoprotein B; Confocal fluorescence microscopy; Hep3B hepatoma cell line; Immunoprecipitation; Triglyceride; Very low density lipoprotein

Indexed keywords

APOLIPOPROTEIN A5; APOLIPOPROTEIN B; FAT DROPLET; TRIACYLGLYCEROL;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; CULTURE MEDIUM; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOLIPOPROTEINS A; APOLIPOPROTEINS B; CELL LINE, TUMOR; CYTOSOL; HUMANS; IMMUNOPRECIPITATION; LIPOPROTEINS, VLDL; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE;

EID: 34548154320     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.C700002-JLR200     Document Type: Article

References (22)

1. Cullen, P. 2000. Evidence that triglycerides are an independent coronary heart disease risk factor. Am. J. Cardiol. 86: 943-949.
2. Pennacchio, L. A., M. Olivier, J. A. Hubacek, J. C. Cohen, D. R. Cox, J. C. Fruchart, R. M. Krauss, and E. M. Rubin. 2001. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science. 294: 169-173.
3. van der Vliet, H. N., M. G. Sammels, A. C. Leegwater, J. H. Levels, P. H. Reitsma, W. Boers, and R. A. Chamuleau. 2001. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J. Biol. Chem. 276: 44512-44520.
4. O'Brien, P. J., W. E. Alborn, J. H. Sloan, M. Ulmer, A. Boodhoo, M. D. Knierman, A. E. Schultze, and R. J. Konrad. 2005. The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. Clin. Chem. 51: 351-359.
5. van der Vliet, H. N., F. G. Schaap, J. H. Levels, R. Ottenhoff, N. Looije, J. G. Wesseling, A. K. Groen, and R. A. Chamuleau. 2002. Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. Biochem. Biophys. Res. Commun. 295: 1156-1159.
6. Vrablik, M., A. Horinek, R. Ceska, V. Adamkova, R. Poledne, and J. A. Hubacek. 2003. Ser19→Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people. J. Med. Genet. 40: e105.
7. Pennacchio, L. A., M. Olivier, J. A. Hubacek, R. M. Krauss, E. M. Rubin, and J. C. Cohen. 2002. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum. Mol. Genet. 11: 3031-3038.
8. Talmud, P. J., J. Palmen, W. Putt, L. Lins, and S. E. Humphries. 2005. Determination of the functionality of common APOA5 polymorphisms. J. Biol. Chem. 280: 28215-28220.
9. Marcais, C., B. Verges, S. Charriere, V. Pruneta, M. Merlin, S. Billon, L. Perrot, J. Drai, A. Sassolas, L. A. Pennacchio, et al. 2005. Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment. J. Clin. Invest. 115: 2862-2869.
10. Oliva, C. P., L. Pisciotta, G. Li Volti, M. P. Sambataro, A. Cantafora, A. Bellocchio, A. Catapano, P. Tarugi, S. Bertolini, and S. Calandra. 2005. Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia. Arterioscler. Thromb. Vasc. Biol. 25: 411-417.
11. Fruchart-Najib, J., E. Bauge, L. S. Niculescu, T. Pham, B. Thomas, C. Rommens, Z. Majd, B. Brewer, L. A. Pennacchio, and J. C. Fruchart. 2004. Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5. Biochem. Biophys. Res. Commun. 319: 397-404.
12. Schaap, F. G., P. C. Rensen, P. J. Voshol, C. Vrins, H. N. van der Vliet, R. A. Chamuleau, L. M. Havekes, A. K. Groen, and K. W. van Dijk. 2004. ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein- triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis. J. Biol. Chem. 279: 27941-27947.
13. Merkel, M., B. Loeffler, M. Kluger, N. Fabig, G. Geppert, L. A. Pennacchio, A. Laatsch, and J. Heeren. 2005. Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase. J. Biol. Chem. 280: 21553-21560.
14. Weinberg, R. B., V. R. Cook, J. A. Beckstead, D. D. Martin, J. W. Gallagher, G. S. Shelness, and R. O. Ryan. 2003. Structure and interfacial properties of human apolipoprotein A-V. J. Biol. Chem. 278: 34438-34444.
15. Beckstead, J. A., M. N. Oda, D. D. Martin, T. M. Forte, J. K. Bielicki, T. Berger, R. Luty, C. M. Kay, and R. O. Ryan. 2003. Structure-function studies of human apolipoprotein A-V: a regulator of plasma lipid homeostasis. Biochemistry. 42: 9416-9423.
16. Wu, X., M. Zhou, L-S. Huang, J. Wetterau, and H. N. Ginsberg. 1996. Demonstration of a physical interaction between microsomal triglyceride transfer protein and apolipoprotein B during the assembly of apoB-containing lipoproteins. J. Biol. Chem. 271: 10277-10281.
17. Dixon, J. L., S. Furukawa, and H. N. Ginsberg. 1991. Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B. J. Biol. Chem. 266: 5080-5086.
18. Tran, K., G. Thorne-Tjomsland, C. J. DeLong, Z. Cui, J. Shan, L. Burton, J. C. Jamieson, and Z. Yao. 2002. Intracellular assembly of very low density lipoproteins containing apolipoprotein B100 in rat hepatoma McA-RH7777 cells. J. Biol. Chem. 277: 31187-31200.
19. Greenspan, P., E. P. Mayer, and S. D. Fowler. 1985. Nile Red: a selective fluorescent stain for intracellular lipid droplets. J. Cell Biol. 100: 965-973.
20. Lookene, A., J. A. Beckstead, S. Nilsson, G. Olivecrona, and R. O. Ryan. 2005. Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism. J. Biol. Chem. 280: 25383-25387.
21. Olofsson, S. O. 2005. ApoA-V: the regulation of a regulator of plasma triglycerides. Arterioscler. Thromb. Vasc. Biol. 25: 1097-1099.
22. Lamant, M., F. Smih, R. Harmancey, P. Philip-Couderc, A. Pathak, J. Roncalli, M. Galinier, X. Collet, P. Massabuau, J. M. Senard, et al. 2006. ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart. J. Biol. Chem. 281: 36289-36302.