The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: Prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II

Diabetologia

Volumn 49, Issue 10, 2006, Pages 2337-2340

  Talmud, P J ^a   Cooper, J A ^a   Hattori, H ^b   Miller, I P ^c   Miller, G J ^d   Humphries, S E ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b BioMedical Laboratories Inc   (Japan)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

APOA5; ApoAV levels; Gene; Type 2 diabetes risk

Indexed keywords

APOLIPOPROTEIN A5; TRIACYLGLYCEROL;

ARTICLE; BODY MASS; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

APOLIPOPROTEINS A; DIABETES MELLITUS, TYPE 2; DNA; GENOTYPE; HUMANS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; TRIGLYCERIDES;

EID: 33748507076     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0387-0     Document Type: Article

References (11)

1. Pennacchio LA, Olivier M, Hubacek JA et al (2001) An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science 294:169-173
2. Pennacchio LA, Olivier M, Hubacek J, Krauss RM, Rubin EM, Cohen JC (2002) Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Gen 11:3031-3038
3. Talmud PJ, Hawe E, Martin S et al (2002) Relative contribution of variation within the APOC3-A4-A5 gene cluster in determining plasma triglycerides. Hum Mol Gen 11:3039-3046
4. Olivier M, Wang X, Cole R et al (2004) Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11. Genomics 83:912-923
5. Miller GJ, Bauer KA, Barzegar S, Cooper JA, Rosenberg RD (1996) Increased activation of the haemostatic system in men at high risk of fatal coronary heart disease. Thromb Haemost 75:767-771
6. Gable DR, Stephens JW, Cooper JA, Miller GJ, Humphries SE (2005) Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in the Northwick Park Heart study II. Diabetes 55:1504-1511
7. Ishihara M, Kujiraoka T, Iwasaki T et al (2005) A sandwich enzyme-linked immunosorbent assay for human plasma apolipoprotein A-V concentration. J Lipid Res 46:2015-2022
8. Merkel M, Heeren J (2005) Give me A5 for lipoprotein hydrolysis! J Clin Invest 115:2694-2696
9. Talmud PJ, Palmen J, Putt W, Lins L, Humphries SE (2005) Determination of the functionality of common APOA5 polymorphisms. J Biol Chem 280:28215-28220
10. Talmud PJ, Martin S, Taskinen MR et al (2004) APOA5 gene variants, lipoprotein particle distribution and progression of coronary heart disease: results from the LOCAT study. J Lipid Res 45:750-756
11. van Dijk KW, Rensen PC, Voshol PJ, Havekes LM (2004) The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism? Curr Opin Lipidol 15:239-246