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Volumn 20, Issue 6, 2017, Pages 360-368

Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease

Author keywords

Alzheimer's disease; Apoptosis; Cognitive dysfunction; Hesperidin; Oxidative stress

Indexed keywords

ALUMINUM CHLORIDE; BETA ACTIN; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HESPERIDIN; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ALUMINUM DERIVATIVE; ANTIOXIDANT; APOPTOSIS REGULATORY PROTEIN; CHLORIDE; NERVE PROTEIN; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT;

EID: 84978524683     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1080/1028415X.2016.1144846     Document Type: Article
Times cited : (122)

References (51)
  • 1
    • 0033575729 scopus 로고    scopus 로고
    • Metal ion transporters and homeostasis
    • Nelson N., Metal ion transporters and homeostasis. EMBO J 1998;18:4361–71. doi:10.1093/emboj/18.16.4361
    • (1998) EMBO J , vol.18 , pp. 4361-4371
    • Nelson, N.1
  • 2
    • 34147210411 scopus 로고    scopus 로고
    • Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder
    • Nunes PV, Forlenza OV, Gattaz WF., Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder. Br J Psychiatry 2007;190:359–60. doi:10.1192/bjp.bp.106.029868
    • (2007) Br J Psychiatry , vol.190 , pp. 359-360
    • Nunes, P.V.1    Forlenza, O.V.2    Gattaz, W.F.3
  • 3
    • 84907618447 scopus 로고    scopus 로고
    • Zinc modulates aluminium-induced oxidative stress and cellular injury in rat brain
    • Singla N, Dhawan DK., Zinc modulates aluminium-induced oxidative stress and cellular injury in rat brain. Metallomics 2014;6:1941–50. doi:10.1039/C4MT00097H
    • (2014) Metallomics , vol.6 , pp. 1941-1950
    • Singla, N.1    Dhawan, D.K.2
  • 4
    • 33846179357 scopus 로고    scopus 로고
    • Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline
    • Waldemar G, Dubois B, Emre M, Georges J, McKeith IG, Rossor M, et al. Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia:EFNS guideline. Eur J Neurol 2007;14:1–26. doi:10.1111/j.1468-1331.2006.01605.x
    • (2007) Eur J Neurol , vol.14 , pp. 1-26
    • Waldemar, G.1    Dubois, B.2    Emre, M.3    Georges, J.4    McKeith, I.G.5    Rossor, M.6
  • 5
    • 15344344684 scopus 로고    scopus 로고
    • Diagnosis and treatment of Alzheimer's disease
    • Monczor M., Diagnosis and treatment of Alzheimer's disease. Curr Med Chem Cent Nerv Syst Agents 2005;5:1–9. doi:10.2174/1568015053202723
    • (2005) Curr Med Chem Cent Nerv Syst Agents , vol.5 , pp. 1-9
    • Monczor, M.1
  • 6
    • 84883209316 scopus 로고    scopus 로고
    • Study of possible protective and therapeutic influence of coriander (Coriandrum sativum L.) against neurodegenerative disorders and Alzheimer's disease induced by aluminum chloride in cerebral cortex of male albino rats
    • Enas AK., Study of possible protective and therapeutic influence of coriander (Coriandrum sativum L.) against neurodegenerative disorders and Alzheimer's disease induced by aluminum chloride in cerebral cortex of male albino rats. Nat Sci 2010;8:202–13.
    • (2010) Nat Sci , vol.8 , pp. 202-213
    • Enas, A.K.1
  • 7
    • 33751086783 scopus 로고    scopus 로고
    • Aluminum and Alzheimer's disease: a new look
    • Miu AC, Benga O., Aluminum and Alzheimer's disease:a new look. J Alzheimers Dis 2006;10:179–201. doi:10.3233/JAD-2006-102-306
    • (2006) J Alzheimers Dis , vol.10 , pp. 179-201
    • Miu, A.C.1    Benga, O.2
  • 8
    • 84875121716 scopus 로고    scopus 로고
    • Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment
    • Linardaki ZI, Orkoula MG, Kokkosis AG, Lamari FN, Margarity M., Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment. Food Chem Toxicol 2013;52:163–70. doi:10.1016/j.fct.2012.11.016
    • (2013) Food Chem Toxicol , vol.52 , pp. 163-170
    • Linardaki, Z.I.1    Orkoula, M.G.2    Kokkosis, A.G.3    Lamari, F.N.4    Margarity, M.5
  • 9
    • 0141516666 scopus 로고    scopus 로고
    • Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain
    • Savory J, Herman MM, Ghribi O., Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain. J Inorg Biochem 2003;97:151–4. doi:10.1016/S0162-0134(03)00258-7
    • (2003) J Inorg Biochem , vol.97 , pp. 151-154
    • Savory, J.1    Herman, M.M.2    Ghribi, O.3
  • 10
    • 84982235765 scopus 로고    scopus 로고
    • Ethological problems and learning disability due to aluminum toxicity in rats
    • Goma AA, Mahrous UE., Ethological problems and learning disability due to aluminum toxicity in rats. Anim Vet Sci 2013;1:12–7. doi:10.11648/j.avs.20130102.11
    • (2013) Anim Vet Sci , vol.1 , pp. 12-17
    • Goma, A.A.1    Mahrous, U.E.2
  • 12
    • 84877073520 scopus 로고    scopus 로고
    • Influence of hesperidin combined with Sinemet on genetical and biochemical abnormalities in rats suffering from Parkinson's disease
    • Salem HRA, El-Raouf AA, Saleh EM, Shalaby KAF., Influence of hesperidin combined with Sinemet on genetical and biochemical abnormalities in rats suffering from Parkinson's disease. Life Sci J 2012;9:930–45.
    • (2012) Life Sci J , vol.9 , pp. 930-945
    • Salem, H.R.A.1    El-Raouf, A.A.2    Saleh, E.M.3    Shalaby, K.A.F.4
  • 13
    • 84885641411 scopus 로고    scopus 로고
    • Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease
    • Tamilselvam K, Braidy N, Manivasagam T, Essa MM, Prasad NR, Karthikeyan S, et al. Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease. Oxid Med Cell Longev 2013;2013:11. doi:10.1155/2013/102741
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 11
    • Tamilselvam, K.1    Braidy, N.2    Manivasagam, T.3    Essa, M.M.4    Prasad, N.R.5    Karthikeyan, S.6
  • 14
    • 70350196372 scopus 로고    scopus 로고
    • Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide
    • Kumar P, Kumar A., Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats:possible role of nitric oxide. Behav Brain Res 2010;206:38–46. doi:10.1016/j.bbr.2009.08.028
    • (2010) Behav Brain Res , vol.206 , pp. 38-46
    • Kumar, P.1    Kumar, A.2
  • 15
    • 84876167900 scopus 로고    scopus 로고
    • Hesperidin ameliorates immobilization stress-induced behavioral and biochemical alterations and mitochondrial dysfunction in mice by modulating nitrergic pathway
    • Viswanatha GL, Shylaja H, Sandeep Rao KS, Santhosh Kumar VR, Jagadeesh M., Hesperidin ameliorates immobilization stress-induced behavioral and biochemical alterations and mitochondrial dysfunction in mice by modulating nitrergic pathway. ISRN Pharmacol 2012;479570. idoi:10.5402/2012/479570.
    • (2012) ISRN Pharmacol
    • Viswanatha, G.L.1    Shylaja, H.2    Sandeep Rao, K.S.3    Santhosh Kumar, V.R.4    Jagadeesh, M.5
  • 16
    • 84866134511 scopus 로고    scopus 로고
    • Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats
    • Ikemura M, Sasaki Y, Giddings JC, Yamamoto J., Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats. Phytother Res 2012;26:1272–7. doi:10.1002/ptr.3724
    • (2012) Phytother Res , vol.26 , pp. 1272-1277
    • Ikemura, M.1    Sasaki, Y.2    Giddings, J.C.3    Yamamoto, J.4
  • 17
    • 80055045555 scopus 로고    scopus 로고
    • Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke
    • Raza SS, Khan MM, Ahmad A, Ashafaq M, Khuwaja G, Tabassum R, et al. Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke. Brain Res 2011;1420:93–105. doi:10.1016/j.brainres.2011.08.047
    • (2011) Brain Res , vol.1420 , pp. 93-105
    • Raza, S.S.1    Khan, M.M.2    Ahmad, A.3    Ashafaq, M.4    Khuwaja, G.5    Tabassum, R.6
  • 18
    • 84937572354 scopus 로고    scopus 로고
    • Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer's disease in Wistar rats
    • Justin Thenmozhi A, Raja TR, Janakiraman U, Manivasagam T., Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer's disease in Wistar rats. Neurochem Res 2015;40:767–76. doi:10.1007/s11064-015-1525-1
    • (2015) Neurochem Res , vol.40 , pp. 767-776
    • Justin Thenmozhi, A.1    Raja, T.R.2    Janakiraman, U.3    Manivasagam, T.4
  • 19
    • 84947022268 scopus 로고    scopus 로고
    • Hesperidin and silibinin ameliorate aluminum-induced neurotoxicity: modulation of antioxidants and inflammatory cytokines level in mice hippocampus
    • Jangra A, Kasbe P, Pandey SN, Dwivedi S, Gurjar SS, Kwatra M, et al. Hesperidin and silibinin ameliorate aluminum-induced neurotoxicity:modulation of antioxidants and inflammatory cytokines level in mice hippocampus. Biol Trace Elem Res 2015;168:462–71. doi:10.1007/s12011-015-0375-7
    • (2015) Biol Trace Elem Res , vol.168 , pp. 462-471
    • Jangra, A.1    Kasbe, P.2    Pandey, S.N.3    Dwivedi, S.4    Gurjar, S.S.5    Kwatra, M.6
  • 20
    • 79955932597 scopus 로고    scopus 로고
    • Rivastigmine reverses aluminum-induced behavioral changes in rats
    • Abdel-Aal RA, Assi AA, Kostandy BB., Rivastigmine reverses aluminum-induced behavioral changes in rats. Eur J Pharmacol 2011;659:169–76. doi:10.1016/j.ejphar.2011.03.011
    • (2011) Eur J Pharmacol , vol.659 , pp. 169-176
    • Abdel-Aal, R.A.1    Assi, A.A.2    Kostandy, B.B.3
  • 21
    • 0025228457 scopus 로고
    • Utility of an elevated plus-maze for the evaluation of memory in mice: effects of nootropics scopolamine and electroconvulsive shock
    • Itoh J, Nabeshima T, Kameyama T., Utility of an elevated plus-maze for the evaluation of memory in mice:effects of nootropics scopolamine and electroconvulsive shock. Psychopharmacology 1990;101:27–33. doi:10.1007/BF02253713
    • (1990) Psychopharmacology , vol.101 , pp. 27-33
    • Itoh, J.1    Nabeshima, T.2    Kameyama, T.3
  • 22
    • 0035200453 scopus 로고    scopus 로고
    • Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum
    • Bhattacharya A, Ghosal S, Bhattacharya SK., Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol 2001;74:1–6. doi:10.1016/S0378-8741(00)00309-3
    • (2001) J Ethnopharmacol , vol.74 , pp. 1-6
    • Bhattacharya, A.1    Ghosal, S.2    Bhattacharya, S.K.3
  • 23
    • 2542581664 scopus 로고    scopus 로고
    • Inhibition of tumor cell growth by overexpression of manganese-containing superoxide dismutase
    • Oberley LW., Inhibition of tumor cell growth by overexpression of manganese-containing superoxide dismutase. Age 1998;21:95–7. doi:10.1007/s11357-998-0014-8
    • (1998) Age , vol.21 , pp. 95-97
    • Oberley, L.W.1
  • 24
    • 0021318441 scopus 로고
    • Catalase invitro
    • Aebi H., Catalase invitro. Methods Enzymol 1984;105:121–6. doi:10.1016/S0076-6879(84)05016-3
    • (1984) Methods Enzymol , vol.105 , pp. 121-126
    • Aebi, H.1
  • 25
    • 0027246660 scopus 로고
    • Glutathione peroxidase isolated from plasma reduces phospholipid hydroperoxide
    • Yamamoto Y, Takahashi K., Glutathione peroxidase isolated from plasma reduces phospholipid hydroperoxide. Arch Biochem Biophys 1993;305:541–5. doi:10.1006/abbi.1993.1458
    • (1993) Arch Biochem Biophys , vol.305 , pp. 541-545
    • Yamamoto, Y.1    Takahashi, K.2
  • 26
    • 0016151122 scopus 로고
    • Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite
    • Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR., Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974;11:151–69. doi:10.1159/000136485
    • (1974) Pharmacology , vol.11 , pp. 151-169
    • Jollow, D.J.1    Mitchell, J.R.2    Zampaglione, N.3    Gillette, J.R.4
  • 28
    • 84937543905 scopus 로고    scopus 로고
    • Protective effect of black tea extract against aluminium chloride-induced Alzheimer's disease in rats: a behavioural, biochemical and molecular approach
    • Mathiyazahan DB, Justin Thenmozhi A, Manivasagam T., Protective effect of black tea extract against aluminium chloride-induced Alzheimer's disease in rats:a behavioural, biochemical and molecular approach. J Funct Foods 2015;16:423–35. doi:10.1016/j.jff.2015.05.001
    • (2015) J Funct Foods , vol.16 , pp. 423-435
    • Mathiyazahan, D.B.1    Justin Thenmozhi, A.2    Manivasagam, T.3
  • 29
    • 0026475216 scopus 로고
    • Learning behaviour in chronic vitamin E deficient and supplemented rats: radial arm maze learning and passive avoidance response
    • Ichitani Y, Okaichi H, Yoshikawa T, Ibata Y., Learning behaviour in chronic vitamin E deficient and supplemented rats:radial arm maze learning and passive avoidance response. Behav Brain Res 1992;51:157–64. doi:10.1016/S0166-4328(05)80209-8
    • (1992) Behav Brain Res , vol.51 , pp. 157-164
    • Ichitani, Y.1    Okaichi, H.2    Yoshikawa, T.3    Ibata, Y.4
  • 30
    • 0038388951 scopus 로고    scopus 로고
    • Modulation of passive avoidance in mice by the 5-HT1A receptor agonist flesinoxan: comparison with the benzodiazepine receptor agonist diazepam
    • Tsuji M, Takeda H, Matsumiya T., Modulation of passive avoidance in mice by the 5-HT1A receptor agonist flesinoxan:comparison with the benzodiazepine receptor agonist diazepam. Neuropsychopharmacology 2003;28:664–74. doi:10.1038/sj.npp.1300080
    • (2003) Neuropsychopharmacology , vol.28 , pp. 664-674
    • Tsuji, M.1    Takeda, H.2    Matsumiya, T.3
  • 32
    • 50949129577 scopus 로고    scopus 로고
    • Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain
    • El-Sayed el SM, Abo-Salem OM, Abd-Ellah MF, Abd-Alla GM., Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain. J Biochem Mol Toxicol 2008;22:268–73. doi:10.1002/jbt.20237
    • (2008) J Biochem Mol Toxicol , vol.22 , pp. 268-273
    • El-Sayed el, S.M.1    Abo-Salem, O.M.2    Abd-Ellah, M.F.3    Abd-Alla, G.M.4
  • 33
    • 1642481207 scopus 로고    scopus 로고
    • The pro-oxidant activity of aluminum
    • Exley C., The pro-oxidant activity of aluminum. Free Radic Biol Med 2004;36:380–7. doi:10.1016/j.freeradbiomed.2003.11.017
    • (2004) Free Radic Biol Med , vol.36 , pp. 380-387
    • Exley, C.1
  • 34
    • 29544449396 scopus 로고    scopus 로고
    • Aluminum-induced neurotoxicity and oxidative damage in rabbits: protective effect of melatonin
    • Abd-Elghaffar SKh, El-Sokkary GH, Sharkawy AA., Aluminum-induced neurotoxicity and oxidative damage in rabbits:protective effect of melatonin. Neuro Endocrinol Lett 2005;26:609–16.
    • (2005) Neuro Endocrinol Lett , vol.26 , pp. 609-616
    • Abd-Elghaffar, S.K.1    El-Sokkary, G.H.2    Sharkawy, A.A.3
  • 35
    • 35348952487 scopus 로고    scopus 로고
    • Further evidence of centrophenoxine mediated protection in aluminium exposed rats by biochemical and light microscopy analysis
    • Nehru B, Bhalla P, Garg A., Further evidence of centrophenoxine mediated protection in aluminium exposed rats by biochemical and light microscopy analysis. Food Chem Toxicol 2007;45:2499–505. doi:10.1016/j.fct.2007.05.026
    • (2007) Food Chem Toxicol , vol.45 , pp. 2499-2505
    • Nehru, B.1    Bhalla, P.2    Garg, A.3
  • 37
    • 4444380150 scopus 로고    scopus 로고
    • Effect of aluminium phosphide exposure on kinetic properties of cytochrome oxidase and mitochondrial energy metabolism in rat brain
    • Dua R, Gill KD., Effect of aluminium phosphide exposure on kinetic properties of cytochrome oxidase and mitochondrial energy metabolism in rat brain. Biochim Biophys Acta 2004;1674:4–11. doi:10.1016/j.bbagen.2004.05.003
    • (2004) Biochim Biophys Acta , vol.1674 , pp. 4-11
    • Dua, R.1    Gill, K.D.2
  • 38
    • 33748340037 scopus 로고    scopus 로고
    • Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin
    • Cho J., Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin. Arch Pharm Res 2006;29:699–706. doi:10.1007/BF02968255
    • (2006) Arch Pharm Res , vol.29 , pp. 699-706
    • Cho, J.1
  • 39
    • 69449089391 scopus 로고    scopus 로고
    • Rutin protects the neural damage induced by transient focal ischemia in rats
    • Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, et al. Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res 2009;1292:123–35. doi:10.1016/j.brainres.2009.07.026
    • (2009) Brain Res , vol.1292 , pp. 123-135
    • Khan, M.M.1    Ahmad, A.2    Ishrat, T.3    Khuwaja, G.4    Srivastawa, P.5    Khan, M.B.6
  • 40
    • 0036774226 scopus 로고    scopus 로고
    • Flavonoid antioxidants: chemistry, metabolism and structure activity relationship
    • Heim KE, Tagliafero AR, Bobilya DJ., Flavonoid antioxidants:chemistry, metabolism and structure activity relationship. J Nutr Biochem 2002;13:572–84. doi:10.1016/S0955-2863(02)00208-5
    • (2002) J Nutr Biochem , vol.13 , pp. 572-584
    • Heim, K.E.1    Tagliafero, A.R.2    Bobilya, D.J.3
  • 41
    • 1042290475 scopus 로고    scopus 로고
    • Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity
    • Spencer JP, Abd-el-Mohsen MM, Rice-Evans C., Cellular uptake and metabolism of flavonoids and their metabolites:implications for their bioactivity. Arch Biochem Biophys 2004;423:148–61. doi:10.1016/j.abb.2003.11.010
    • (2004) Arch Biochem Biophys , vol.423 , pp. 148-161
    • Spencer, J.P.1    Abd-el-Mohsen, M.M.2    Rice-Evans, C.3
  • 42
    • 84912051590 scopus 로고    scopus 로고
    • Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease
    • Wang D, Liu L, Zhu X, Wu W, Wang Y., Hesperidin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress in a mouse model of Alzheimer's disease. Cell Mol Neurobiol 2014;34:1209–21. doi:10.1007/s10571-014-0098-x
    • (2014) Cell Mol Neurobiol , vol.34 , pp. 1209-1221
    • Wang, D.1    Liu, L.2    Zhu, X.3    Wu, W.4    Wang, Y.5
  • 43
    • 77955058931 scopus 로고    scopus 로고
    • Relationship between apoptosis of rat hippocampus cells induced by aluminum and the copy of the bcl-2 as well as bax mRNA
    • Niu Q, Wang LP, Chen YL, Zhang HM., Relationship between apoptosis of rat hippocampus cells induced by aluminum and the copy of the bcl-2 as well as bax mRNA. Wei Sheng Yan Jiu 2005;34:671–3.
    • (2005) Wei Sheng Yan Jiu , vol.34 , pp. 671-673
    • Niu, Q.1    Wang, L.P.2    Chen, Y.L.3    Zhang, H.M.4
  • 44
    • 84901813146 scopus 로고    scopus 로고
    • Docosahexaenoic acid ameliorates aluminum induced biochemical and morphological alteration in rat cerebellum
    • Chaudhary M, Joshi DK, Tripathi S, Kulshrestha S, Mahdi AA., Docosahexaenoic acid ameliorates aluminum induced biochemical and morphological alteration in rat cerebellum. Ann Neurosci 2014;21:5–9.
    • (2014) Ann Neurosci , vol.21 , pp. 5-9
    • Chaudhary, M.1    Joshi, D.K.2    Tripathi, S.3    Kulshrestha, S.4    Mahdi, A.A.5
  • 45
    • 63349085790 scopus 로고    scopus 로고
    • Globular adiponectin-induced RAW 264 apoptosis is regulated by a reactive oxygen species dependent pathway involving Bcl-2
    • Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Nishihara T, Yamashita Y., Globular adiponectin-induced RAW 264 apoptosis is regulated by a reactive oxygen species dependent pathway involving Bcl-2. Free Radic Biol Med 2009;46:1308–16. doi:10.1016/j.freeradbiomed.2009.02.014
    • (2009) Free Radic Biol Med , vol.46 , pp. 1308-1316
    • Akifusa, S.1    Kamio, N.2    Shimazaki, Y.3    Yamaguchi, N.4    Nishihara, T.5    Yamashita, Y.6
  • 46
    • 84873037839 scopus 로고    scopus 로고
    • Studies on apoptosis and caspase-8 and caspase-9 expressions of bone marrow cells in chronic mountain sickness
    • Cai YL, Cui S, Li ZQ, Wang HX, Ji LH, Chai KX., Studies on apoptosis and caspase-8 and caspase-9 expressions of bone marrow cells in chronic mountain sickness. Zhonghua Xue Ye Xue Za Zhi 2011;32:762–5.
    • (2011) Zhonghua Xue Ye Xue Za Zhi , vol.32 , pp. 762-765
    • Cai, Y.L.1    Cui, S.2    Li, Z.Q.3    Wang, H.X.4    Ji, L.H.5    Chai, K.X.6
  • 47
    • 84931259963 scopus 로고    scopus 로고
    • Hesperidin, a citrus flavonoid, has the ameliorative effects against experimental autoimmune encephalomyelitis (EAE) in a C57BL/J6 mouse model
    • Ciftci O, Ozcan C, Kamisli O, Cetin A, Basak N, Aytac B., Hesperidin, a citrus flavonoid, has the ameliorative effects against experimental autoimmune encephalomyelitis (EAE) in a C57BL/J6 mouse model. Neurochem Res 2015;40:1111–20. doi:10.1007/s11064-015-1571-8
    • (2015) Neurochem Res , vol.40 , pp. 1111-1120
    • Ciftci, O.1    Ozcan, C.2    Kamisli, O.3    Cetin, A.4    Basak, N.5    Aytac, B.6
  • 48
    • 84907841725 scopus 로고    scopus 로고
    • Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by d-galactose in rat brain
    • Banji OJ, Banji D, Ch K., Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by d-galactose in rat brain. Food Chem Toxicol 2014;74:51–9. doi:10.1016/j.fct.2014.08.020
    • (2014) Food Chem Toxicol , vol.74 , pp. 51-59
    • Banji, O.J.1    Banji, D.2    Ch, K.3
  • 49
    • 84908357224 scopus 로고    scopus 로고
    • Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model
    • Oztanir MN, Ciftci O, Cetin A, Aladag MA., Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model. Neurol Sci 2014;35:1393–9. doi:10.1007/s10072-014-1725-5
    • (2014) Neurol Sci , vol.35 , pp. 1393-1399
    • Oztanir, M.N.1    Ciftci, O.2    Cetin, A.3    Aladag, M.A.4
  • 50
    • 80051842687 scopus 로고    scopus 로고
    • 2-induced cytotoxicity in PC12 cells
    • 2-induced cytotoxicity in PC12 cells. J Agric Food Chem 2008;56:859–64. doi:10.1021/jf072826r
    • (2008) J Agric Food Chem , vol.56 , pp. 859-864
    • Hwang, S.L.1    Yen, G.C.2
  • 51
    • 84889595357 scopus 로고    scopus 로고
    • Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway
    • Wang JJ, Cui P., Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway. J Asian Nat Prod Res 2013;15:1023–37. doi:10.1080/10286020.2013.827176
    • (2013) J Asian Nat Prod Res , vol.15 , pp. 1023-1037
    • Wang, J.J.1    Cui, P.2


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