Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway

Journal of Asian Natural Products Research

Volumn 15, Issue 9, 2013, Pages 1023-1037

  Wang, Ji Jun ^a   Cui, Ping ^b  

^a SHAANXI PROVINCIAL PEOPLE S HOSPITAL   (China)

^b Xi'an Institute for Drug Control   (China)

Author keywords

apoptosis; cerebral ischemia and reperfusion injury; heme oxygenase 1; nuclear factor erythroid 2 related factor 2; oxidative stress

Indexed keywords

CASPASE 3; CASPASE 9; CATALASE; CYTOCHROME C; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEME OXYGENASE 1; NEOHESPERIDIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; HESPERIDIN; NEUROPROTECTIVE AGENT; NFE2L2 PROTEIN, RAT; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; COMMON CAROTID ARTERY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; EXTERNAL CAROTID ARTERY; FORELIMB; IMMUNOHISTOCHEMISTRY; INTERNAL CAROTID ARTERY; LATENT PERIOD; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOLECULAR DYNAMICS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REPERFUSION INJURY; STRUCTURE ACTIVITY RELATION; UPREGULATION; WEAKNESS; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CEREBRAL ARTERY DISEASE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

CITRUS; RATTUS;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN ISCHEMIA; CASPASE 9; HEME OXYGENASE-1; HESPERIDIN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; UP-REGULATION;

EID: 84889595357     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2013.827176     Document Type: Article

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