Relationship between retinal perfusion and retinal thickness in healthy subjects: An optical coherence tomography angiography study

Investigative Ophthalmology and Visual Science

Volumn 57, Issue 9, 2016, Pages OCT204-OCT210

  Yu, Jian ^a,b   Gu, Ruiping ^a,b   Zong, Yuan ^a,b   Xu, Huan ^a,b   Wang, Xiaolei ^a,b   Sun, Xinghuai ^a,b   Jiang, Chunhui ^a,c   Xie, Bing ^e   Jia, Yali ^d   Huang, David ^d  

^a FUDAN UNIVERSITY   (China)

^b Key Laboratory of Myopia of State Health Ministry   (China)

^c Department of Neurology   (China)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Capillary free zone (CFZ); Macular perfusion; Optical coherence tomography (OCT) angiogram; Retinal thickness; Split spectrum amplitude decorrelation angiography (SSADA) algorithm

Indexed keywords

ADULT; ANGIOGRAPHY; ARTICLE; DIASTOLIC BLOOD PRESSURE; EYE REFRACTION; FEMALE; HUMAN; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RETINAL PERFUSION; RETINAL THICKNESS; SLIT LAMP; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; SPLIT SPECTRUM AMPLITUDE DECORRELATION ANGIOGRAPHY; SYSTOLIC BLOOD PRESSURE; TISSUE PERFUSION; VISUAL ACUITY; BLOOD FLOW; DIAGNOSTIC IMAGING; EYE FUNDUS; FLUORESCENCE ANGIOGRAPHY; FOLLOW UP; MICROCIRCULATION; MIDDLE AGED; OPTIC DISK; OPTICAL COHERENCE TOMOGRAPHY; PHYSIOLOGY; PROCEDURES; RETINA; RETINA BLOOD VESSEL; RETROSPECTIVE STUDY; YOUNG ADULT;

ADULT; FEMALE; FLUORESCEIN ANGIOGRAPHY; FOLLOW-UP STUDIES; FUNDUS OCULI; HEALTHY VOLUNTEERS; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; OPTIC DISK; REGIONAL BLOOD FLOW; RETINA; RETINAL VESSELS; RETROSPECTIVE STUDIES; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY; YOUNG ADULT;

EID: 84978511893     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-18630     Document Type: Article

References (39)

1. Yu DY, Cringle SJ. Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Retin Eye Res. 2001; 20: 175-208.
2. Zhu W, Cui M, Yao F, Liao R, Liu L. Retrobulbar and common carotid artery haemodynamics and carotid wall thickness in patients with non-arteritic anterior ischaemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2014; 252: 1141-1146.
3. Costa VP, Lanzl I, Gugleta K, et al. Ocular perfusion pressure in glaucoma. Acta Ophthalmol. 2014; 92: e252-e266.
4. Sehi M, Goharian I, Konduru R, et al. Retinal blood flow in glaucomatous eyes with single-hemifield damage. Ophthalmology. 2014; 121: 750-758.
5. Falsini B, Anselmi GM, Marangoni D, et al. Subfoveal choroidal blood flow and central retinal function in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2011; 52: 1064-1069.
6. Zeitz O, Galambos P, Wagenfeld L, et al. Glaucoma progression is associated with decreased blood flow velocities in the short posterior ciliary artery. Br J Ophthalmol. 2006; 90: 1245-1248.
7. Zheng Y, Cheung N, Aung T, Mitchell P, He M, Wong TY. Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the Singapore Malay Eye Study. Invest Ophthalmol Vis Sci. 2009; 50: 4091-4096.
8. Cheung N, Huynh S, Wang JJ, et al. Relationships of retinal vessel diameters with optic disc, macular and retinal nerve fiber layer parameters in 6-year-old children. Invest Ophthalmol Vis Sci. 2008; 49: 2403-2408.
9. Østergaard L, Finnerup NB, Terkelsen AJ, et al. The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy. Diabetologia. 2015; 58: 666-677.
10. Alterman M, Henkind P. Radial peripapillary capillaries of the retina. II. Possible role in Bjerrum scotoma. Br J Ophthalmol. 1968; 52: 26-31.
11. Ashton N. Pathophysiology of retinal cotton-wool spots. Br Med Bull. 1970; 26: 143-150.
12. Daicker B. Selective atrophy of the radial peripapillary capillaries and visual field defects in glaucoma [in German]. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1975; 195: 27-32.
13. Agarwal A. Gass’ Atlas of Macular Diseases. 5th ed. Philadelphia: Saunders; 2011: 1-10.
14. Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography. Science. 1991; 254: 1178-1181.
15. Wolf S, Wolf-Schnurrbusch U. Spectral-domain optical coherence tomography use in macular diseases: a review. Ophthalmologica. 2010; 224: 333-340.
16. Yu J, Ni Y, Keane PA, Jiang C, Wang W, Xu G. Foveomacular schisis in juvenile X-linked retinoschisis: an optical coherence tomography study. Am J Ophthalmol. 2010; 149: 973-978.
17. Strom C, Sander B, Larsen N, Larsen M, Lund-Andersen H. Diabetic macular edema assessed with optical coherence tomography and stereo fundus photography. Invest Ophthalmol Vis Sci. 2002; 43: 241-245.
18. Yu J, Jiang C, Wang X, et al. Macular perfusion in healthy Chinese: an optical coherence tomography angiogram study. Invest Ophthalmol Vis Sci. 2015; 56: 3212-3217.
19. Jia Y, Wei E, Wang X, et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma. Ophthalmology. 2014; 121: 1322-1332.
20. Wang X, Jia Y, Spain R, et al. Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis. Br J Ophthalmol. 2014; 98: 1368-1373.
21. Wei E, Jia Y, Tan O, et al. Parafoveal retinal vascular response to pattern visual stimulation assessed with OCT angiography. PLoS One. 2013; 8: e81343.
22. Pechauer AD, Jia Y, Liu L, Gao SS, Jiang C, Huang D. Optical coherence tomography angiography of peripapillary retinal blood flow response to hyperoxia. Invest Ophthalmol Vis Sci. 2015; 56: 3287-3291.
23. Jia Y, Morrison JC, Tokayer J, et al. Quantitative OCT angiography of optic nerve head blood flow. Biomed Opt Express. 2012; 3: 3127-3137.
24. Jia Y, Bailey ST, Wilson DJ, et al. Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology. 2014; 12: 1435-1444.
25. Spaide RF, Klancnik JM, Cooney MJ. Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography. JAMA Ophthalmol. 2015; 133: 45.
26. Jia Y, Tan O, Tokayer J, et al. Split-spectrum amplitudedecorrelation angiography with optical coherence tomography. Opt Express. 2012; 20: 4710-4725.
27. Chan G, Balaratnasingam C, Yu PK, et al. Quantitative morphometry of perifoveal capillary networks in the human retina. Invest Ophthalmol Vis Sci. 2012; 53: 5502-5514.
28. Tham YC, Cheng CY, Zheng Y, Aung T, Wong TY, Cheung CY. Relationship between retinal vascular geometry with retinal nerve fiber layer and ganglion cell-inner plexiform layer in nonglaucomatous eyes. Invest Ophthalmol Vis Sci. 2013; 54: 7309-7316.
29. Yu PK, Cringle SJ, Yu D. Correlation between the radial peripapillary capillaries and the retinal nerve fibre layer in the normal human retina. Exp Eye Res. 2014; 129: 83-92.
30. Kur J, Newman EA, Chan-Ling T. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Prog Retin Eye Res. 2012; 31: 377-406.
31. Burgansky-Eliash Z, Lowenstein A, Neuderfer M, et al. The correlation between retinal blood flow velocity measured by the retinal function imager and various physiological parameters. Ophthalmic Surg Lasers Imaging Retina. 2013; 44: 51-58.
32. Landa G, Garcia PMT, Rosen RB. Correlation between retina blood flow velocity assessed by retinal function imager and retina thickness estimated by scanning laser ophthalmoscopy/optical coherence tomography. Ophthalmologica. 2009; 223: 155-161.
33. Garhofer G, Werkmeister R, Dragostinoff N, Schmetterer L. Retinal blood flow in healthy young subjects. Invest Ophthalmol Vis Sci. 2012; 53: 698-703.
34. Rougier M, Korobelnik J, Malet F, et al. Retinal nerve fibre layer thickness measured with SD-OCT in a population-based study of French elderly subjects: the Alienor study. Acta Ophthalmologica. 2015; 93: 539-545.
35. Tariq YM, Li H, Burlutsky G, Mitchell P. Retinal nerve fiber layer and optic disc measurements by spectral domain OCT: normative values and associations in young adults. Eye (Lond). 2012; 26: 1563-1570.
36. Chui TYP, Zhong Z, Song H, Burns SA. Foveal avascular zone and its relationship to foveal pit shape. Optometry Vision Sci. 2012; 89: 602-610.
37. Tick S, Rossant F, Ghorbel I, et al. Foveal shape and structure in a normal population. Invest Ophthalmol Vis Sci. 2011; 52: 5105-5110.
38. Scarinci F, Jampol LM, Linsenmeier RA, Fawzi AA. Association of diabetic macular nonperfusion with outer retinal disruption on optical coherence tomography. JAMA Ophthalmol. 2015; 133: 1036-1044.
39. Kimura I, Shinoda K, Tanino T, Ohtake Y, Mashima Y, Oguchi Y. Scanning laser Doppler flowmeter study of retinal blood flow in macular area of healthy volunteers. Br J Ophthalmol. 2003; 87: 1469-1473