Computer-aided design, structural dynamics analysis, and in vitro susceptibility test of antibacterial peptides incorporating unnatural amino acids against microbial infections

Computer Methods and Programs in Biomedicine

Volumn 134, Issue , 2016, Pages 215-223

  Wang, Yan ^a   Yang, Yong Jian ^b   Chen, Ya Na ^b   Zhao, Hong Yu ^b   Zhang, Shuai ^c  

^a First People's Hospital of Jining   (China)

^b SHANDONG UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

Antibacterial peptide; Bioinformatics; Infectious disease; Machine learning; Rational peptide design

Indexed keywords

AMINO ACIDS; ARTIFICIAL INTELLIGENCE; BACTERIA; BIOCHEMISTRY; BIOINFORMATICS; COMPUTER AIDED DESIGN; DESIGN; ESCHERICHIA COLI; LEARNING SYSTEMS; LIPID BILAYERS; MOLECULAR DYNAMICS; PEPTIDES; STRUCTURAL DYNAMICS; STRUCTURAL OPTIMIZATION;

ANTIBACTERIAL PEPTIDES; ARTIFICIAL LIPID BILAYERS; COMPUTER AIDED MODELING; INFECTIOUS DISEASE; MACHINE LEARNING MODELS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS SIMULATIONS; PEPTIDE DESIGN;

COMPUTER AIDED ANALYSIS;

AMINO ACID DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; UNNATURAL AMINO ACID; ANTIINFECTIVE AGENT; PEPTIDE;

ALGORITHM; AMINO ACID COMPOSITION; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL INFECTION; BROTH DILUTION; COMPUTER AIDED DESIGN; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; LIPID BILAYER; MACHINE LEARNING; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUPPORT VECTOR MACHINE; MICROBIAL SENSITIVITY TEST;

ALGORITHMS; ANTI-BACTERIAL AGENTS; COMPUTER-AIDED DESIGN; MACHINE LEARNING; MICROBIAL SENSITIVITY TESTS; PEPTIDES;

EID: 84978488828     PISSN: 01692607     EISSN: 18727565     Source Type: Journal    
DOI: 10.1016/j.cmpb.2016.06.005     Document Type: Article

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