TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer

International Journal of Oncology

Volumn 49, Issue 3, 2016, Pages 1046-1056

  Liang, Fang ^a,b,c   Li, Qiao ^a,b,c   Li, Xiayu ^c   Li, Zheng ^a,b,c   Gong, Zhaojian ^b,d   Deng, Hao ^c   Xiang, Bo ^a,b,c   Zhou, Ming ^a,b,c   Li, Xiaoling ^a,b,c   Li, Guiyuan ^a,b,c   Zeng, Zhaoyang ^a,b,c   Xiong, Wei ^a,b,c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cell growth; Colorectal cancer; Cyclin D1; Pyruvate kinase isoform M2; TSC22 domain family member 2

Indexed keywords

CYCLIN D1; PYRUVATE KINASE; PYRUVATE KINASE M2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA STIMULATED CLONE 22 DOMAIN FAMILY MEMBER 2; UNCLASSIFIED DRUG; CARRIER PROTEIN; CCND1 PROTEIN, HUMAN; MEMBRANE PROTEIN; THYROID HORMONE; THYROID HORMONE-BINDING PROTEINS; TSC22D2 PROTEIN, HUMAN;

ARTICLE; CANCER INHIBITION; COLON CARCINOGENESIS; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; CELL CYCLE; CELL NUCLEUS; CELL PROLIFERATION; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TUMOR CELL LINE;

CARRIER PROTEINS; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; CYCLIN D1; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE PROTEINS; THYROID HORMONES;

EID: 84978472254     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3599     Document Type: Article

References (29)

1. Li Q, Chen P, Zeng Z, Liang F, Song Y, Xiong F, Li X, Gong Z, Zhou M, Xiang B, et al: Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2. Tumor Biol (In press).
2. Yoon CH, Rho SB, Kim ST, Kho S, Park J, Jang IS, Woo S, Kim SS, Lee JH and Lee SH: Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer. PLoS One 7: e42006, 2012.
3. Choi SJ, Moon JH, Ahn YW, Ahn JH, Kim DU and Han TH: Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation. Mol Cell Biochem 271: 23-28, 2005.
4. Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F and Riccardi C: Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. Blood 98: 743-753, 2001.
5. Ayroldi E, Petrillo MG, Bastianelli A, Marchetti MC, Ronchetti S, Nocentini G, Ricciotti L, Cannarile L and Riccardi C: L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells. Cell Death Differ 22: 118-130, 2015.
6. Ayroldi E, Zollo O, Bastianelli A, Marchetti C, Agostini M, Di Virgilio R and Riccardi C: GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling. J Clin Invest 117: 1605-1615, 2007.
7. Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL and Cantley LC: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452: 230-233, 2008.
8. Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, et al: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol 8: 839-847, 2012.
9. Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, et al: Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal 2: ra73, 2009.
10. Chen Z, Wang Z, Guo W, Zhang Z, Zhao F, Zhao Y, Jia D, Ding J, Wang H, Yao M, et al: TRIM35 interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma. Oncogene 34: 3946-3956, 2015.
11. Chaneton B and Gottlieb E: Rocking cell metabolism: Revised functions of the key glycolytic regulator PKM2 in cancer. Trends Biochem Sci 37: 309-316, 2012.
12. Luo W and Semenza GL: Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol Metab 23: 560-566, 2012.
13. Lv L, Xu YP, Zhao D, Li FL, Wang W, Sasaki N, Jiang Y, Zhou X, Li TT, Guan KL, et al: Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Mol Cell 52: 340-352, 2013.
14. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC and Lu Z: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol 14: 1295-1304, 2012.
15. Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK and Lu Z: PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150: 685-696, 2012.
16. Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K and Lu Z: Nuclear PKM2 regulates catenin transactivation upon EGFR activation. Nature 480: 118-122, 2011.
17. Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A and Semenza GL: Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145: 732-744, 2011.
18. Lee J, Kim HK, Han YM and Kim J: Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol 40: 1043-1054, 2008.
19. Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, et al: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125: 801-814, 2006.
20. Landschulz WH, Johnson PF and McKnight SL: The leucine zipper: A hypothetical structure common to a new class of DNA binding proteins. Science 240: 1759-1764, 1988.
21. Kouzarides T and Ziff E: Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding. Nature 340: 568-571, 1989.
22. Busch SJ and Sassone-Corsi P: Dimers, leucine zippers and DNA-binding domains. Trends Genet 6: 36-40, 1990.
23. Hashiguchi A, Hitachi K, Inui M, Okabayashi K and Asashima M: TSC-box is essential for the nuclear localization and antiproliferative effect of XTSC-22. Dev Growth Differ 49: 197-204, 2007.
24. Hino S, Kawamata H, Uchida D, Omotehara F, Miwa Y, Begum N M, Yoshida H, Fujimori T and Sato M: Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator. Biochem Biophys Res Commun 278: 659-664, 2000.
25. Nakamura M, Kitaura J, Enomoto Y, Lu Y, Nishimura K, Isobe M, Ozaki K, Komeno Y, Nakahara F, Oki T, et al: Transforming growth factor-stimulated clone-22 is a negative-feedback regulator of Ras /Raf signaling: Implications for tumorigenesis. Cancer Sci 103: 26-33, 2012.
26. Gluderer S, Brunner E, Germann M, Jovaisaite V, Li C, Rentsch CA, Hafen E and Stocker H: Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. J Biol 9: 9, 2010.
27. Kester HA, Blanchetot C, den Hertog J, van der Saag PT and van der Burg B: Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo-and heterodimerize and has transcriptional repressor activity. J Biol Chem 274: 27439-27447, 1999.
28. Gao X, Wang H, Yang JJ, Liu X and Liu ZR: Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol Cell 45: 598-609, 2012.
29. Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ, et al: JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1mediated glucose metabolism. Proc Natl Acad Sci USA 111: 279-284, 2014.