메뉴 건너뛰기




Volumn , Issue , 2016, Pages 936-947

A Review of New Pharmacologic Treatments for Patients With Chronic Heart Failure With Reduced Ejection Fraction

Author keywords

f channel inhibitor; heart failure with reduced ejection fraction; ivabradine; neprilysin inhibitor; sacubitril; valsartan

Indexed keywords

3 (1 BIPHENYL 4 YLMETHYL 3 CARBOXY 1 BUTYLCARBAMOYL)PROPIONIC ACID; ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; BISOPROLOL; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN; CAPTOPRIL; CARVEDILOL; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENKEPHALINASE INHIBITOR; EPLERENONE; HYDRALAZINE; ISOSORBIDE DINITRATE; IVABRADINE; KETOCONAZOLE; LOSARTAN; MEMBRANE METALLOENDOPEPTIDASE; METOPROLOL SUCCINATE; OMAPATRILAT; PLACEBO; SACUBITRIL; SACUBITRIL PLUS VALSARTAN; SPIRONOLACTONE; TICAGRELOR; VALSARTAN;

EID: 84978405418     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1002/jcph.677     Document Type: Review
Times cited : (4)

References (70)
  • 1
    • 84922381210 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2015 update: a report from the American Heart Association
    • Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation. 2015;131:e29–322.
    • (2015) Circulation , vol.131 , pp. 29-322
    • Mozaffarian, D.1    Benjamin, E.J.2    Go, A.S.3
  • 2
    • 84884294190 scopus 로고    scopus 로고
    • 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
    • Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;62:e147–239.
    • (2013) J Am Coll Cardiol , vol.62 , pp. 147-239
    • Yancy, C.W.1    Jessup, M.2    Bozkurt, B.3
  • 3
    • 0025913812 scopus 로고
    • Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
    • The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991;325:293–302.
    • (1991) N Engl J Med , vol.325 , pp. 293-302
  • 4
    • 0022623381 scopus 로고
    • Effect of vasodilator therapy on mortality in chronic congestive heart failure
    • Cohn JN, Archibald DG, Phil M, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure. N Engl J Med. 1986;314:1547–1552.
    • (1986) N Engl J Med , vol.314 , pp. 1547-1552
    • Cohn, J.N.1    Archibald, D.G.2    Phil, M.3
  • 5
    • 0025770138 scopus 로고
    • A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure
    • Cohn JN, Johnson G, Ziesche S, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med. 1991;325:303–310.
    • (1991) N Engl J Med , vol.325 , pp. 303-310
    • Cohn, J.N.1    Johnson, G.2    Ziesche, S.3
  • 6
    • 0029937949 scopus 로고    scopus 로고
    • The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
    • Packer M, Bristow MR, Cohn JN, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med. 1996;334:1349–1355.
    • (1996) N Engl J Med , vol.334 , pp. 1349-1355
    • Packer, M.1    Bristow, M.R.2    Cohn, J.N.3
  • 7
    • 0033549290 scopus 로고    scopus 로고
    • Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomized Intervention Trial in congestive Heart Failure (MERIT-HF)
    • MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomized Intervention Trial in congestive Heart Failure (MERIT-HF). Lancet. 1999;353:2001–2007.
    • (1999) Lancet , vol.353 , pp. 2001-2007
  • 8
    • 0033514046 scopus 로고    scopus 로고
    • The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomized trial
    • CIBIS-II Investigators and Committees. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomized trial. Lancet. 1999;353:9–13.
    • (1999) Lancet , vol.353 , pp. 9-13
  • 9
    • 0034612118 scopus 로고    scopus 로고
    • Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II
    • Pitt B, Poole-Wilson PA, Segal R, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II. Lancet. 2000;355:1582–1587.
    • (2000) Lancet , vol.355 , pp. 1582-1587
    • Pitt, B.1    Poole-Wilson, P.A.2    Segal, R.3
  • 10
    • 0041909380 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial
    • Granger CB, McMurray JJ, Yusurf S, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet. 2003;363:772–776.
    • (2003) Lancet , vol.363 , pp. 772-776
    • Granger, C.B.1    McMurray, J.J.2    Yusurf, S.3
  • 11
    • 0035818884 scopus 로고    scopus 로고
    • A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure
    • Cohn JN, Tognoni G, Valsartan Heart Failure Trial Investigators.A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N Engl J Med. 2001;345:1667–1675.
    • (2001) N Engl J Med , vol.345 , pp. 1667-1675
    • Cohn, J.N.1    Tognoni, G.2
  • 12
    • 0041408235 scopus 로고    scopus 로고
    • Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-convertign-enzyme inhibitors: the CHARM-Added trial
    • McMurray JJ, Ostergren J, Swedberg K, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-convertign-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003;362:767–771.
    • (2003) Lancet , vol.362 , pp. 767-771
    • McMurray, J.J.1    Ostergren, J.2    Swedberg, K.3
  • 13
    • 0032836517 scopus 로고    scopus 로고
    • Racial differences in response to therapy for heart failure: analysis of the vasodilator-heart failure trials. Vasodilator-Heart Failure Trial Study Group
    • Carson P, Ziesche S, Johnson G, Cohn JN. Racial differences in response to therapy for heart failure: analysis of the vasodilator-heart failure trials. Vasodilator-Heart Failure Trial Study Group. J Card Fail. 1999;5:178–187.
    • (1999) J Card Fail. , vol.5 , pp. 178-187
    • Carson, P.1    Ziesche, S.2    Johnson, G.3    Cohn, J.N.4
  • 14
    • 19644400578 scopus 로고    scopus 로고
    • Combination of isosorbide dinitrate and hydralazine in blacks with heart failure
    • Taylor AL, Ziesche S, Yancy C, et al. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004;351:2049–2057.
    • (2004) N Engl J Med , vol.351 , pp. 2049-2057
    • Taylor, A.L.1    Ziesche, S.2    Yancy, C.3
  • 15
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med. 1999;341:709–717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 16
    • 78650399880 scopus 로고    scopus 로고
    • Eplerenone in patients with systolic heart failure and mild symptoms
    • Zannad F, McMurray JJ, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364:11–21.
    • (2011) N Engl J Med. , vol.364 , pp. 11-21
    • Zannad, F.1    McMurray, J.J.2    Krum, H.3
  • 18
    • 66649100010 scopus 로고    scopus 로고
    • Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure
    • Mcalister FA, Wiebe N, Ezekowitz JA, Leung AA, Armstrong PW. Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure. Ann Intern Med. 2009;150:784–794.
    • (2009) Ann Intern Med , vol.150 , pp. 784-794
    • Mcalister, F.A.1    Wiebe, N.2    Ezekowitz, J.A.3    Leung, A.A.4    Armstrong, P.W.5
  • 19
    • 33750115878 scopus 로고    scopus 로고
    • Beta-blockade in CHF: pathophysiological considerations
    • Silke B. Beta-blockade in CHF: pathophysiological considerations. Eur Heart J. 2006;8(Suppl C):C13–C18.
    • (2006) Eur Heart J. , vol.8 , pp. C13-C18
    • Silke, B.1
  • 20
    • 0027530224 scopus 로고
    • Pacemaker mechanisms in cardiac tissue
    • Difrancesco D. Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol. 1993;55:455–472.
    • (1993) Annu Rev Physiol , vol.55 , pp. 455-472
    • Difrancesco, D.1
  • 21
    • 0029039601 scopus 로고
    • Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations
    • Perez O, Gay P, Franqueza L et al. Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations. Br J Pharmacol. 1995;115:787–794.
    • (1995) Br J Pharmacol , vol.115 , pp. 787-794
    • Perez, O.1    Gay, P.2    Franqueza, L.3
  • 22
    • 0036020147 scopus 로고    scopus 로고
    • Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine
    • Bucchi A, Baruscotti M, Difrancesco D. Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. J Gen Physiol. 2002;120:1–13.
    • (2002) J Gen Physiol , vol.120 , pp. 1-13
    • Bucchi, A.1    Baruscotti, M.2    Difrancesco, D.3
  • 23
    • 79952206215 scopus 로고    scopus 로고
    • Safety of ivabradine in patients with coronary artery disease and left ventricular systolic dysfunction (from the BEAUTIFUL Holter Substudy)
    • Tendera M, Talajic M, Robertson M, et al. Safety of ivabradine in patients with coronary artery disease and left ventricular systolic dysfunction (from the BEAUTIFUL Holter Substudy). Am J Cardiol. 2011;107:805–811.
    • (2011) Am J Cardiol , vol.107 , pp. 805-811
    • Tendera, M.1    Talajic, M.2    Robertson, M.3
  • 24
    • 0031685461 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers
    • Ragueneau I, Laveille C, Jochemsen R, Resplandy G, Funck-Brentano C, Jaillon P. Pharmacokinetic-pharmacodynamic modeling of the effects of ivabradine, a direct sinus node inhibitor, on heart rate in healthy volunteers. Clin Pharmacol Ther. 1998;64:192–203.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 192-203
    • Ragueneau, I.1    Laveille, C.2    Jochemsen, R.3    Resplandy, G.4    Funck-Brentano, C.5    Jaillon, P.6
  • 25
    • 85028479895 scopus 로고    scopus 로고
    • Corlanor [package insert]. Thousand Oaks, CA: Amgen Inc; 2015.
  • 26
    • 85028479701 scopus 로고    scopus 로고
    • Entresto [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2015.
  • 28
    • 3042813668 scopus 로고    scopus 로고
    • Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance
    • Abassi Z, Karram T, Ellaham S, Winaver J, Hoffman A. Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance. Pharmacol Ther. 2004;102:223–241.
    • (2004) Pharmacol Ther , vol.102 , pp. 223-241
    • Abassi, Z.1    Karram, T.2    Ellaham, S.3    Winaver, J.4    Hoffman, A.5
  • 29
    • 34250358937 scopus 로고    scopus 로고
    • Natriuretic peptides and therapeutic applications
    • Lee CYW, Burnett JC Jr. Natriuretic peptides and therapeutic applications. Heart Fail Rev. 2007;12:131–142.
    • (2007) Heart Fail Rev. , vol.12 , pp. 131-142
    • Lee, C.Y.W.1    Burnett, J.C.2
  • 30
    • 45849110678 scopus 로고    scopus 로고
    • The role of natiruetic peptides in heart failure
    • Correa de Sa DD, Chen HH. The role of natiruetic peptides in heart failure. Curr Cardiol Rep. 2008;10:182–189.
    • (2008) Curr Cardiol Rep , vol.10 , pp. 182-189
    • Correa de Sa, D.D.1    Chen, H.H.2
  • 31
    • 46249090767 scopus 로고    scopus 로고
    • Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular disease
    • Rubattu S, Sciarreta S, Valenti V, Stanzione R, Volpe M. Natriuretic peptides: an update on bioactivity, potential therapeutic use, and implication in cardiovascular disease. Am J Hypertens. 2008;21:733–741.
    • (2008) Am J Hypertens , vol.21 , pp. 733-741
    • Rubattu, S.1    Sciarreta, S.2    Valenti, V.3    Stanzione, R.4    Volpe, M.5
  • 32
    • 84940614889 scopus 로고    scopus 로고
    • Antiogtensin receptor neprilysin inhibition in heart failure: mechanistic action and clinical impact
    • Buggey J, Mentz RJ, DeVore AD, Velazquez EJ. Antiogtensin receptor neprilysin inhibition in heart failure: mechanistic action and clinical impact. J Card Fail. 2015;21:741–750.
    • (2015) J Card Fail , vol.21 , pp. 741-750
    • Buggey, J.1    Mentz, R.J.2    DeVore, A.D.3    Velazquez, E.J.4
  • 34
    • 77956817833 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)
    • Gu J, Noe A, Chandra P, Al-Fayoumi S, et al. Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi). J Clin Pharmacol. 2010;50:401–414.
    • (2010) J Clin Pharmacol , vol.50 , pp. 401-414
    • Gu, J.1    Noe, A.2    Chandra, P.3    Al-Fayoumi, S.4
  • 35
    • 84944625183 scopus 로고    scopus 로고
    • Dual angiotensin receptor and neprilyin inhibition in chronic systolic heart failure: understanding the new PARADIGM
    • Lillyblad MP. Dual angiotensin receptor and neprilyin inhibition in chronic systolic heart failure: understanding the new PARADIGM. Ann Pharmacother. 2015;49:1237–1251.
    • (2015) Ann Pharmacother , vol.49 , pp. 1237-1251
    • Lillyblad, M.P.1
  • 36
    • 84924331425 scopus 로고    scopus 로고
    • Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances
    • McMurrary JJ. Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances. Eur J Heart Fail. 2015;17:242–247.
    • (2015) Eur J Heart Fail , vol.17 , pp. 242-247
    • McMurrary, J.J.1
  • 37
    • 79960090547 scopus 로고    scopus 로고
    • Effect of nesiritide in patients with acute decompensated heart failure
    • O'Connor CM, Starling RC, Hernandez AF, et al. Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med. 2011;365:32–43.
    • (2011) N Engl J Med , vol.365 , pp. 32-43
    • O'Connor, C.M.1    Starling, R.C.2    Hernandez, A.F.3
  • 38
    • 0032948546 scopus 로고    scopus 로고
    • The endopeptidase inhibitor, candoxatril, and its therapeutic potential in the treatment of chronic cardiac failure in man
    • McDowell G, Nicholls DP. The endopeptidase inhibitor, candoxatril, and its therapeutic potential in the treatment of chronic cardiac failure in man. Exp Opin Invest Drugs. 1999;8:79–84.
    • (1999) Exp Opin Invest Drugs , vol.8 , pp. 79-84
    • McDowell, G.1    Nicholls, D.P.2
  • 39
    • 0031044502 scopus 로고    scopus 로고
    • The effect of neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides
    • McDowell G, Coutie W, Shaw C, Buchanan KD, Struthers AD, Nicholls DP. The effect of neutral endopeptidase inhibitor drug, candoxatril, on circulating levels of two of the most potent vasoactive peptides. Br J Clin Pharmacol. 1997;43:329–332.
    • (1997) Br J Clin Pharmacol , vol.43 , pp. 329-332
    • McDowell, G.1    Coutie, W.2    Shaw, C.3    Buchanan, K.D.4    Struthers, A.D.5    Nicholls, D.P.6
  • 40
    • 0037143601 scopus 로고    scopus 로고
    • Comparison of omapatrilat and enalapril in patients with chronic heart failure
    • Packer M, Califf RM, Konstam MA, et al. Comparison of omapatrilat and enalapril in patients with chronic heart failure. Circulation. 2002;106:920–926.
    • (2002) Circulation , vol.106 , pp. 920-926
    • Packer, M.1    Califf, R.M.2    Konstam, M.A.3
  • 41
    • 85028479585 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research Division of Cardio-Renal Drug Products. Food and Drug Administration. Joint Statistical-Clinical Review NDA 21-188. http://www.fda.gov/ohrms/dockets/ac/02/briefing/3877B2_03_FDA-Medial-Statistical.htm. Accessed September 4, 2015.
  • 42
    • 84879096446 scopus 로고    scopus 로고
    • Natriuretic peptide inhibition in the presence of angiotensin receptor blockade following short-term treatment with LCZ696 in heart failure patients: effect on ANP, BNP, NT-proBNP, and cGMP
    • Kobalava Z, Averkov O, Meray I, et al. Natriuretic peptide inhibition in the presence of angiotensin receptor blockade following short-term treatment with LCZ696 in heart failure patients: effect on ANP, BNP, NT-proBNP, and cGMP. Eur Heart J. 2011;32(abstract suppl):784–785.
    • (2011) Eur Heart J , vol.32 , Issue.abstract suppl , pp. 784-785
    • Kobalava, Z.1    Averkov, O.2    Meray, I.3
  • 43
    • 84900810340 scopus 로고    scopus 로고
    • Changes in RAAS (renin angiotensin aldosterone system) biomarkers in stable chronic heart failure (HF) patients following short-term angiotensin receptor neprilysin inhibitor (ARNI) treatment
    • Jordaan P, Albrecht D, Feng A, et al. Changes in RAAS (renin angiotensin aldosterone system) biomarkers in stable chronic heart failure (HF) patients following short-term angiotensin receptor neprilysin inhibitor (ARNI) treatment. SA Heart. 2011;8:236.
    • (2011) SA Heart , vol.8 , pp. 236
    • Jordaan, P.1    Albrecht, D.2    Feng, A.3
  • 44
    • 84927670188 scopus 로고    scopus 로고
    • LCZ696 (angiotensin-neprilysin inhibition): the new kid on the heart failure block?
    • Pham AQ, Patel Y, Gallagher B. LCZ696 (angiotensin-neprilysin inhibition): the new kid on the heart failure block? J Pharm Pract. 2015;28:137–145.
    • (2015) J Pharm Pract , vol.28 , pp. 137-145
    • Pham, A.Q.1    Patel, Y.2    Gallagher, B.3
  • 45
    • 85028479837 scopus 로고    scopus 로고
    • European Medicines Agency. Procoralan (ivabradine): Summary of Product Characteristics. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000597/WC500043590.pdf. Accessed October 22, 2015.
  • 46
    • 33847133030 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the pharmacological induction of phosphenes
    • Cervetto L, Demontis GC, Gargini C. Cellular mechanisms underlying the pharmacological induction of phosphenes. Br J Pharmacol. 2007;150:383–390.
    • (2007) Br J Pharmacol , vol.150 , pp. 383-390
    • Cervetto, L.1    Demontis, G.C.2    Gargini, C.3
  • 47
    • 0343391203 scopus 로고    scopus 로고
    • Simultaneous determination of ivabradine and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry
    • Francois-bouchard M, Simonin G, Bossant MJ, Boursier-Neyret C. Simultaneous determination of ivabradine and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Biomed Sci Appl. 2000;745:261-269.
    • (2000) J Chromatogr B Biomed Sci Appl , vol.745 , pp. 261-269
    • Francois-bouchard, M.1    Simonin, G.2    Bossant, M.J.3    Boursier-Neyret, C.4
  • 48
    • 84927635082 scopus 로고    scopus 로고
    • Assessment of drug interaction potential between LCZ696 and warfarin
    • Ayalasomayajula S, Jordaan P, Pal P, et al. Assessment of drug interaction potential between LCZ696 and warfarin. Hypertension. 2013;62:A448.
    • (2013) Hypertension , vol.62 , pp. 448
    • Ayalasomayajula, S.1    Jordaan, P.2    Pal, P.3
  • 49
    • 79959935821 scopus 로고    scopus 로고
    • Clinical importance of OATP1B1 and OATP1B3 in drug-drug interactions
    • Shitara Y. Clinical importance of OATP1B1 and OATP1B3 in drug-drug interactions. Drug Metab Pharmacokinet. 2011;26:220–227.
    • (2011) Drug Metab Pharmacokinet , vol.26 , pp. 220-227
    • Shitara, Y.1
  • 50
    • 75549088606 scopus 로고    scopus 로고
    • The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy
    • Romaine SPR, Bailey KM, Hall AS, Balmforth AJ. The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy. Pharmacogenom J. 2010;10:1–11.
    • (2010) Pharmacogenom J , vol.10 , pp. 1-11
    • Romaine, S.P.R.1    Bailey, K.M.2    Hall, A.S.3    Balmforth, A.J.4
  • 51
    • 50649109186 scopus 로고    scopus 로고
    • Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial
    • Fox K, Ford I, Steg PG, Tendera M, Ferrari R, BEAUTIFUL Investigators. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet. 2008;372:807–816.
    • (2008) Lancet , vol.372 , pp. 807-816
    • Fox, K.1    Ford, I.2    Steg, P.G.3    Tendera, M.4    Ferrari, R.5
  • 52
    • 77956612624 scopus 로고    scopus 로고
    • Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
    • Swedberg K, Komajda M, Böhm M, et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet. 2010;376:875–885.
    • (2010) Lancet , vol.376 , pp. 875-885
    • Swedberg, K.1    Komajda, M.2    Böhm, M.3
  • 53
    • 84872333445 scopus 로고    scopus 로고
    • Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study
    • Böhm M, Borer J, Ford I, et al. Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study. Clin Res Cardiol. 2013;102:11–22.
    • (2013) Clin Res Cardiol , vol.102 , pp. 11-22
    • Böhm, M.1    Borer, J.2    Ford, I.3
  • 54
    • 10544223267 scopus 로고    scopus 로고
    • Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators
    • Bristow MR, Gilbert EM, Abraham WT, et al. Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators. Circulation. 1996;94:2807–2816.
    • (1996) Circulation. , vol.94 , pp. 2807-2816
    • Bristow, M.R.1    Gilbert, E.M.2    Abraham, W.T.3
  • 55
    • 84856260028 scopus 로고    scopus 로고
    • Medication dosing in outpatients with heart failure after implementation of a practice-based performance improvement intervention: findings from IMPROVE HF
    • Gheorghiade M, Albert NM, Curtis AB, et al. Medication dosing in outpatients with heart failure after implementation of a practice-based performance improvement intervention: findings from IMPROVE HF. Congest Heart Fail. 2012;18:9-17.
    • (2012) Congest Heart Fail , vol.18 , pp. 9-17
    • Gheorghiade, M.1    Albert, N.M.2    Curtis, A.B.3
  • 56
    • 84871182616 scopus 로고    scopus 로고
    • Influence of background treatment with mineralocorticoid receptor antagonists on ivabradine's effects in patients with chronic heart failure
    • Komajda M, Böhm M, Borer J, et al. Influence of background treatment with mineralocorticoid receptor antagonists on ivabradine's effects in patients with chronic heart failure. Eur J Heart Fail. 2013;15:79–84.
    • (2013) Eur J Heart Fail , vol.15 , pp. 79-84
    • Komajda, M.1    Böhm, M.2    Borer, J.3
  • 57
    • 84889019398 scopus 로고    scopus 로고
    • Efficacy and safety of ivabradine in chronic heart failure across the age spectrum: insights from the SHIFT study
    • Tavazzi L, Swedberg K, Komajda M, et al. Efficacy and safety of ivabradine in chronic heart failure across the age spectrum: insights from the SHIFT study. Eur J Heart Fail. 2013;15:1296–303.
    • (2013) Eur J Heart Fail , vol.15 , pp. 1296-1303
    • Tavazzi, L.1    Swedberg, K.2    Komajda, M.3
  • 58
    • 46349083598 scopus 로고    scopus 로고
    • The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction—baseline characteristics of the study population
    • Beautiful Study Group, Ferrari R, Ford I, Fox K, Steg PG, Tendera M. The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction—baseline characteristics of the study population. Cardiology. 2008;110:271–282.
    • (2008) Cardiology , vol.110 , pp. 271-282
    • Ferrari, R.1    Ford, I.2    Fox, K.3    Steg, P.G.4    Tendera, M.5
  • 59
    • 72649084586 scopus 로고    scopus 로고
    • Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I(f) Inhibitor Ivabradine Trial (SHIFT)
    • Swedberg K, Komajda M, Böhm M, Borer JS, Ford I, Tavazzi L. Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the I(f) Inhibitor Ivabradine Trial (SHIFT). Eur J Heart Fail. 2010;12:75–81.
    • (2010) Eur J Heart Fail , vol.12 , pp. 75-81
    • Swedberg, K.1    Komajda, M.2    Böhm, M.3    Borer, J.S.4    Ford, I.5    Tavazzi, L.6
  • 60
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361:1045–57.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 61
    • 80051550924 scopus 로고    scopus 로고
    • Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial
    • Mahaffey KW, Wojdyla DM, Carroll K, et al. Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2011;124:544–554.
    • (2011) Circulation , vol.124 , pp. 544-554
    • Mahaffey, K.W.1    Wojdyla, D.M.2    Carroll, K.3
  • 62
    • 19944429413 scopus 로고    scopus 로고
    • Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure
    • Bardy GH, Lee KL, Mark DB, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225–237.
    • (2005) N Engl J Med , vol.352 , pp. 225-237
    • Bardy, G.H.1    Lee, K.L.2    Mark, D.B.3
  • 63
    • 70349625757 scopus 로고    scopus 로고
    • Cardiac-resynchronization therapy for the prevention of heart-failure events
    • Moss AJ, Hall WJ, Cannom DS, et al. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009;361:1329–1338.
    • (2009) N Engl J Med , vol.361 , pp. 1329-1338
    • Moss, A.J.1    Hall, W.J.2    Cannom, D.S.3
  • 64
    • 78650215892 scopus 로고    scopus 로고
    • Cardiac-resynchronization therapy for mild-to-moderate heart failure
    • Tang AS, Wells GA, Talajic M, et al. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med. 2010;363:2385–2395.
    • (2010) N Engl J Med , vol.363 , pp. 2385-2395
    • Tang, A.S.1    Wells, G.A.2    Talajic, M.3
  • 65
    • 0028299731 scopus 로고
    • Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study
    • Benjamin EJ, Levy D, Vaziri SM, D'Agostino RB, Belanger AJ, Wolf PA. Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA. 1994;271:840–844.
    • (1994) JAMA. , vol.271 , pp. 840-844
    • Benjamin, E.J.1    Levy, D.2    Vaziri, S.M.3    D'Agostino, R.B.4    Belanger, A.J.5    Wolf, P.A.6
  • 66
    • 84907087561 scopus 로고    scopus 로고
    • Angiotensin-nepriysin inhibition versus enalapril in heart failure
    • McMurray JJ, Packer M, Desai AK, et al. Angiotensin-nepriysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371:993–1004.
    • (2014) N Engl J Med , vol.371 , pp. 993-1004
    • McMurray, J.J.1    Packer, M.2    Desai, A.K.3
  • 67
    • 84880206504 scopus 로고    scopus 로고
    • Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)
    • McMurray JJ, Packer M, Desai AS, et al. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Herat Fail. 2013;15:1062–1073.
    • (2013) Eur J Herat Fail , vol.15 , pp. 1062-1073
    • McMurray, J.J.1    Packer, M.2    Desai, A.S.3
  • 68
    • 84939603387 scopus 로고    scopus 로고
    • Effect of angiotensin-receptor neprilyin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients
    • Desai AS, McMurray JJ, Packer M, et al. Effect of angiotensin-receptor neprilyin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients. Eur Heart J. 2015;36:1990–1997.
    • (2015) Eur Heart J , vol.36 , pp. 1990-1997
    • Desai, A.S.1    McMurray, J.J.2    Packer, M.3
  • 69
    • 85028479694 scopus 로고    scopus 로고
    • Unger EF, Food and Drug Administration. NDA 207620 Approval Letter. http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2015/207620Orig1s000ltr.pdf. Accessed September 4, 2015.
  • 70
    • 84903771354 scopus 로고    scopus 로고
    • Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)
    • McMurray JJ, Packer M, Desai AS, et al. Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF). Eur J Heart Fail. 2014;16:814–825.
    • (2014) Eur J Heart Fail , vol.16 , pp. 814-825
    • McMurray, J.J.1    Packer, M.2    Desai, A.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.