Safety of ivabradine in patients with coronary artery disease and left ventricular systolic dysfunction (from the BEAUTIFUL Holter substudy)

American Journal of Cardiology

Volumn 107, Issue 6, 2011, Pages 805-811

  Tendera, Michal ^a   Talajic, Mario ^b   Robertson, Michele ^c   Tardif, Jean Claude ^b   Ferrari, Roberto ^d   Ford, Ian ^c   Steg, P Gabriel ^e   Fox, Kim ^f  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b MONTREAL HEART INSTITUTE   (Canada)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF FERRARA   (Italy)

^e INSERM   (France)

^f ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; IVABRADINE; METOPROLOL SUCCINATE; METOPROLOL TARTRATE; PLACEBO;

ADULT; AMBULATORY MONITORING; ARTICLE; BRADYCARDIA; COMBINATION CHEMOTHERAPY; COMPLETE HEART BLOCK; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FIRST DEGREE ATRIOVENTRICULAR BLOCK; HEART ATRIUM FIBRILLATION; HEART LEFT VENTRICLE CONTRACTION; HEART RATE; HEART VENTRICLE TACHYCARDIA; HOLTER MONITORING; HUMAN; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; NONSUSTAINED SUPRAVENTRICULAR TACHYCARDIA; PRIORITY JOURNAL; SECOND DEGREE ATRIOVENTRICULAR BLOCK; SLEEP; SUPRAVENTRICULAR TACHYCARDIA; SUSTAINED SUPRAVENTRICULAR TACHYCARDIA; SYSTOLIC DYSFUNCTION; TREATMENT RESPONSE; WAKEFULNESS;

EID: 79952206215     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2010.10.065     Document Type: Article

References (17)

1. f current inhibition with ivabradine A new therapeutic perspective in cardiovascular disease Drugs 64 2004 1757 1765
2. f inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial Circulation 107 2003 817 823 (Pubitemid 36241038)
3. L. Lopez-Bescos, S. Filipova, and R. Martos Long-term safety and efficacy of ivabradine in patients with chronic stable angina Cardiology 108 2007 387 396 (Pubitemid 350130092)
4. f inhibitor, compared with atenolol in patients with chronic stable angina Eur Heart J 26 2005 2529 2536 (Pubitemid 41677303)
5. W. Ruzyllo, M. Tendera, I. Ford, and K.M. Fox Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial Drugs 67 2007 393 405 (Pubitemid 46425552)
6. f current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4 month, randomized, placebo-controlled trial Eur Heart J 30 2009 540 548
7. f current inhibitor ivabradine: safety considerations Adv Cardiol 43 2006 79 96 (Pubitemid 44290165)
8. K. Fox, I. Ford, P.G. Steg, M. Tendera, and R. Ferrari Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial Lancet 372 2008 807 816
9. K. Fox, R. Ferrari, M. Tendera, P.G. Steg, and I. Ford Rationale and design of a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease and left ventricular dysfunction: the morBidity-mortality EvAlUation of the If inhibitor ivabradine in patients with coronary disease and left ventricULar dysfunction (BEAUTIFUL) Study Am Heart J 152 2006 860 866 (Pubitemid 44632933)
10. J.M. Clarke, J. Hamer, J.R. Shelton, S. Taylor, and G.R. Venning The rhythm of the normal human heart Lancet 1 1976 508 512
11. J.B. Kostis, A.E. Moreyra, M.T. Amendo, P.J. Di, N. Cosgrove, and P.T. Kuo The effect of age on heart rate in subjects free of heart disease Studies by ambulatory electrocardiography and maximal exercise stress test Circulation 65 1982 141 145 (Pubitemid 12250901)
12. F. Jaquet, I.B. Goldstein, and D. Shapiro Effects of age and gender on ambulatory blood pressure and heart rate J Hum Hypertens 12 1998 253 257 (Pubitemid 28197284)
13. P. Bois, J. Bescond, B. Renaudon, and J. Lenfant Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells Br J Pharmacol 118 1996 1051 1057 (Pubitemid 26261281)
14. f channels by ivabradine J Gen Physiol 120 2002 1 13 (Pubitemid 34755772)
15. A. Bucchi, A. Tognati, R. Milanesi, M. Baruscotti, and D. DiFrancesco Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels J Physiol 572 2006 335 346
16. f inhibition with ivabradine: electrophysiological effects and safety Drug Saf 31 2008 95 107 (Pubitemid 351175614)
17. A.J. Camm, and C.P. Lau Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology Drugs R D 4 2003 83 89 (Pubitemid 37062655)