The composition of the Microbiota modulates allograft rejection

Journal of Clinical Investigation

Volumn 126, Issue 7, 2016, Pages 2736-2744

  Lei, Yuk Man ^a   Chen, Luqiu ^a   Wang, Ying ^a   Stefka, Andrew T ^a   Molinero, Luciana L ^a   Theriault, Betty ^a   Aquino Michaels, Keston ^a   Sivan, Ayelet S ^a   Nagler, Cathryn R ^a   Gajewski, Thomas F ^a   Chong, Anita S ^a   Bartman, Caroline ^a   Alegre, Maria Luisa ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL DNA; BACTERIAL RNA; COLISTIN; INTERFERON; KANAMYCIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; METRONIDAZOLE; RNA 16S; VANCOMYCIN; ANTIINFECTIVE AGENT; HLA ANTIGEN CLASS 2;

ADOPTIVE TRANSFER; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC PROPHYLAXIS; ANTIGEN PRESENTING CELL; ARTICLE; BACTERIAL LOAD; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; FEEDING; FEMALE; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; MALE; MICROBIAL COLONIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN ALLOGRAFT; SKIN FLORA; SKIN GRAFT; T LYMPHOCYTE; ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CYTOLOGY; GENE EXPRESSION REGULATION; IMMUNOLOGY; LEUKOCYTE; METABOLISM; MICROBIOLOGY; MICROFLORA; ORGAN TRANSPLANTATION; SKIN; SKIN TRANSPLANTATION; TREATMENT OUTCOME;

ALLOGRAFTS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIGEN-PRESENTING CELLS; FEMALE; GENE EXPRESSION REGULATION; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS CLASS II; LEUKOCYTES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROBIOTA; ORGAN TRANSPLANTATION; SKIN; SKIN TRANSPLANTATION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 84978387811     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI85295     Document Type: Article

References (38)

1. Ahmed EB, Wang T, Daniels M, Alegre ML, Chong AS. IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice. Am J Transplant. 2011; 11 (5):936-946.
2. Wang T, et al. Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model. Am J Transplant. 2010; 10 (7):1524-1533.
3. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Cell. 2014; 157 (1):121-141.
4. Goldstein DR, Tesar BM, Akira S, Lakkis FG. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest. 2003; 111 (10):1571-1578.
5. Oh PL, Martinez I, Sun Y, Walter J, Peterson DA, Mercer DF. Characterization of the ileal microbiota in rejecting and nonrejecting recipients of small bowel transplants. Am J Transplant. 2012; 12 (3):753-762.
6. Charlson ES, et al. Lung-enriched organisms and aberrant bacterial and fungal respiratory microbiota after lung transplant. Am J Respir Crit Care Med. 2012; 186 (6):536-545.
7. Stefka AT, et al. Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci U S A. 2014; 111 (36):13145-13150.
8. Theriault B, Wang Y, Chen L, Vest A, Bartman C, Alegre ML. Long-term maintenance of sterility following skin transplantation in germ-free mice. Transplant Direct. 2015; 1 (8):e28.
9. Itoh K, Mitsuoka T. Characterization of clostridia isolated from faeces of limited flora mice and their effect on caecal size when associated with germ-free mice. Lab Anim. 1985; 19 (2):111-118.
10. Liu C, Finegold SM, Song Y, Lawson PA. Reclassification of Clostridium coccoides, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus luti, Ruminococcus productus and Ruminococcus schinkii as Blautia coccoides gen. Nov., comb. Nov., Blautia hansenii comb. Nov., Blautia hydrogenotrophica comb. Nov., Blautia luti comb. Nov., Blautia producta comb. Nov., Blautia schinkii comb. Nov. and description of Blautia wexlerae sp. Nov., isolated from human faeces. Int J Syst Evol Microbiol. 2008; 58 (pt 8):1896-1902.
11. Reed AJ, et al. Alloreactive CD4 T cell activation in vivo: an autonomous function of the indirect pathway of alloantigen presentation. J Immunol. 2003; 171 (12):6502-6509.
12. Atif SM, et al. Cutting Edge: roles for Batf3dependent APCs in the rejection of minor histocompatibility antigen-mismatched grafts. J Immunol. 2015; 195 (1):46-50.
13. Naik S, et al. Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Nature. 2015; 5 (7545):104-108.
14. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2011; 108 (suppl 1):4615-4622.
15. Wu HJ, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity. 2010; 32 (6):815-827.
16. Giannoukakis N, et al. Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides. Mol Ther. 2000; 1 (5 Pt 1):430-437.
17. Stravitz RT, et al. Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation. Liver Transpl. 2004; 10 (7):850-858.
18. Cook CH, et al. Disruption of murine cardiac allograft acceptance by latent cytomegalovirus. Am J Transplant. 2009; 9 (1):42-53.
19. + T cells is associated with latent infection-mediated resistance to transplantation tolerance. J Immunol. 2008; 180 (5):3190-3200.
20. Wang T, et al. Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol. 2008; 180 (9):5991-5999.
21. Ganal SC, et al. Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity. 2012; 37 (1):171-186.
22. Abt MC, et al. Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 2012; 37 (1):158-170.
23. Sivan A, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PDL1 efficacy. Science. 2015; 350 (6264):1084-1089.
24. Shen H, et al. Haptoglobin activates innate immunity to enhance acute transplant rejection in mice. J Clin Invest. 2012; 122 (1):383-387.
25. Tesar BM, Zhang J, Li Q, Goldstein DR. TH1 immune responses to fully MHC mismatched allografts are diminished in the absence of MyD88, a toll-like receptor signal adaptor protein. Am J Transplant. 2004; 4 (9):1429-1439.
26. Brubaker SW, Bonham KS, Zanoni I, Kagan JC. Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol. 2015; 33:257-290.
27. Atarashi K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. 2013; 500 (7461):232-236.
28. Arpaia N, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 13 (7480):451-455.
29. Furusawa Y, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013; 13 (7480):446-450.
30. Smith PM, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013; 341 (6145):569-573.
31. Abdala E, et al. Bacterial translocation during liver transplantation: a randomized trial comparing conventional with venovenous bypass vs. piggyback methods. Liver Transpl. 2007; 13 (4):488-496.
32. Perez-Diez A, et al. CD4 cells can be more efficient at tumor rejection than CD8 cells. Blood. 2007; 109 (12):5346-5354.
33. Corry RJ, Winn HJ, Russell PS. Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejection. Transplantation. 1973; 16 (4):343-350.
34. Yuan X, et al. A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med. 2008; 1 (13):3133-3144.
35. Tanaka M, et al. In vivo visualization of cardiac allograft rejection and trafficking passenger leukocytes using bioluminescence imaging. Circulation. 2005; 112 (9 suppl):I105-I110.
36. Caporaso JG, et al. Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms. ISME J. 2012; 6 (8):1621-1624.
37. Caporaso JG, et al. QIIME allows analysis of highthroughput community sequencing data. Nat Methods. 2010; 7 (5):335-336.
38. Lozupone C, Knight R. UniFrac: a new phylogenetic method for comparing microbial communities. Appl Environ Microbiol. 2005; 71 (12):8228-8235.