Aptamer BC 007 – A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors

European Journal of Pharmacology

Volumn 789, Issue , 2016, Pages 37-45

  Haberland, Annekathrin ^a   Holtzhauer, Martin ^b   Schlichtiger, Alice ^c   Bartel, Sabine ^d   Schimke, Ingolf ^a   Müller, Johannes ^e   Dandel, Michael ^f   Luppa, Peter B ^c   Wallukat, Gerd ^d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Human Gesellschaft für Biochemie und Diagnostica mbH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e Berlin Space Technologies GmbH   (Germany)

^f DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Aptamer; Autoantibody; Dilated cardiomyopathy; G protein coupled receptors; Immunoadsorption; Therapy

Indexed keywords

APTAMER; APTAMER BC 007; AUTOANTIBODY; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG; BETA 1 ADRENERGIC RECEPTOR; MUSCARINIC M2 RECEPTOR;

ANIMAL CELL; ANTIBODY NEUTRALIZATION; ANTIBODY RESPONSE; ARTICLE; BINDING AFFINITY; CARDIAC MUSCLE CELL; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; IMMUNOLOGICAL PARAMETERS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; ADSORPTION; ANIMAL; BINDING SITE; CHEMISTRY; CONGESTIVE CARDIOMYOPATHY; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; RABBIT; SPECIES DIFFERENCE;

ADSORPTION; ANIMALS; APTAMERS, NUCLEOTIDE; AUTOANTIBODIES; BINDING SITES; CARDIOMYOPATHY, DILATED; HUMANS; RABBITS; RATS; RECEPTOR, MUSCARINIC M2; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, G-PROTEIN-COUPLED; SPECIES SPECIFICITY;

EID: 84978372304     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.06.061     Document Type: Article

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