Questionable Validity of Peptide-Based ELISA Strategies in the Diagnostics of Cardiopathogenic Autoantibodies That Activate G-Protein-Coupled Receptors

Cardiology (Switzerland)

Volumn 131, Issue 3, 2015, Pages 149-150

  Jahns, Roland ^a   Boege, Fritz ^b  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; G PROTEIN COUPLED RECEPTOR; PEPTIDE; ANGIOTENSIN 1 RECEPTOR; BETA 1 ADRENERGIC RECEPTOR;

CARDIOVASCULAR DISEASE; CONFORMATIONAL TRANSITION; CONGESTIVE CARDIOMYOPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART VENTRICLE ARRHYTHMIA; HUMAN; HYPERTENSION; IMMUNOASSAY; LETTER; PRIORITY JOURNAL; VALIDITY; FEMALE; HEART LEFT VENTRICLE HYPERTROPHY; IMMUNOLOGY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS;

AUTOANTIBODIES; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; MALE; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ADRENERGIC, BETA-1;

EID: 84928723058     PISSN: 00086312     EISSN: 14219751     Source Type: Journal    
DOI: 10.1159/000376546     Document Type: Letter

References (24)

1. Zhao L, Xu C, Xu J: Autoantibodies against 1 receptor and AT1 receptor in type 2 diabetes patients with left ventricular dilatation. Cardiology 2014; 129: 191-196.
2. Landsberger M: Autoantibodies in type 2 diabetes patients with left ventricular dilatation: biomarkers and/or risk markers? Cardiology 2014; 129: 189-190.
3. Stork S, Boivin V, Horf R, Hein L, Lohse MJ, Angermann CE, Jahns R: Stimulating autoantibodies directed against the cardiac beta1-adrenergic receptor predict increased mortality in idiopathic cardiomyopathy. Am Heart J 2006; 152: 697-704.
4. Wallukat G, Homuth V, Fischer T, Lindschau C, Horstkamp B, Jupner A, Baur E, Nissen E, Vetter K, Neichel D, Dudenhausen JW, Haller H, Luft FC: Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. J Clin Invest 1999; 103: 945-952.
5. Dragun D, Muller DN, Brasen JH, Fritsche L, Nieminen-Kelha M, Dechend R, Kintscher U, Rudolph B, Hoebeke J, Eckert D, Mazak I, Plehm R, Schonemann C, Unger T, Budde K, Neumayer HH, Luft FC, Wallukat G: Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. N Engl J Med 2005; 352: 558-569.
6. Fu ML, Herlitz H, Wallukat G, Hilme E, Hedner T, Hoebeke J, Hjalmarson A: Functional autoimmune epitope on alpha 1-adrenergic receptors in patients with malignant hypertension. Lancet 1994; 344: 1660-1663.
7. Luther HP, Homuth V, Wallukat G: Alpha 1-adrenergic receptor antibodies in patients with primary hypertension. Hypertension 1997; 29: 678-682.
8. Wenzel K, Haase H, Wallukat G, Derer W, Bartel S, Homuth V, Herse F, Hubner N, Schulz H, Janczikowski M, Lindschau C, Schroeder C, Verlohren S, Morano I, Muller DN, Luft FC, Dietz R, Dechend R, Karczewski P: Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension. PLoS One 2008; 3:e3742.
9. Bornholz B, Roggenbuck D, Jahns R, Boege F: Diagnostic and therapeutic aspects of 1-adrenergic receptor autoantibodies in human heart disease. Autoimmun Rev 2014; 13: 954-962.
10. Boivin V, Beyersdorf N, Palm D, Nikolaev VO, Schlipp A, Muller J, Schmidt D, Kocoski V, Kerkau T, Hunig T, Ertl G, Lohse MJ, Jahns R: Novel receptor-derived cyclopeptides to treat heart failure caused by anti-1-adrenoceptor antibodies in a human-analogous rat model. PLoS One 2015; 10:e0117589.
11. Jin Z, Wang J, Zhang W, Zhang G, Jiao X, Zhi J: Changes in cardiac structure and function in rats immunized by angiotensin type 1 receptor peptides. Acta Biochim Biophys Sin (Shanghai) 2011; 43: 970-976.
12. Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC: High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 2007; 318: 1258-1265.
13. Huang J, Chen S, Zhang JJ, Huang XY: Crystal structure of oligomeric 1-adrenergic G protein-coupled receptors in ligand-free basal state. Nat Struct Mol Biol 2013; 20: 419-425.
14. Bornholz B, Weidtkamp-Peters S, Schmitmeier S, Seidel CA, Herda LR, Felix SB, Lemoine H, Hescheler J, Nguemo F, Schafer C, Christensen MO, Mielke C, Boege F: Impact of human autoantibodies on 1-adrenergic receptor conformation, activity, and internalization. Cardiovasc Res 2013; 97: 472-480.
15. Jahns R, Boivin V, Siegmund C, Inselmann G, Lohse MJ, Boege F: Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation 1999; 99: 649-654.
16. Nikolaev VO, Boivin V, Stork S, Angermann CE, Ertl G, Lohse MJ, Jahns R: A novel fluorescence method for the rapid detection of functional beta1-adrenergic receptor autoantibodies in heart failure. J Am Coll Cardiol 2007; 50: 423-431.
17. Pei J, Li N, Chen J, Li X, Zhang Y, Wang Z, Zhang P, Cao K, Pu J: The predictive values of beta1-adrenergic and M2 muscarinic receptor autoantibodies for sudden cardiac death in patients with chronic heart failure. Eur J Heart Fail 2012; 14: 887-894.
18. Arndt-Maric R, Nagele H, Schewe G, Kromminga A: Are autoantibodies against the beta1-adrenergic receptor markers for dilated cardiomyopathy? Clin Lab 2010; 56: 519-526.
19. Deubner N, Berliner D, Schlipp A, Gelbrich G, Caforio AL, Felix SB, Fu M, Katus H, Angermann CE, Lohse MJ, Ertl G, Stork S, Jahns R: Cardiac beta1-adrenoceptor autoantibodies in human heart disease: Rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study. Eur J Heart Fail 2010; 12: 753-762.
20. Haberland A, Wallukat G, Berg S, Schulz AM, Freyse EJ, Vetter R, Salzsieder E, Muller J, Kreutz R, Schimke I: Neutralization of pathogenic beta1-receptor autoantibodies by aptamers in vivo: the first successful proof of principle in spontaneously hypertensive rats. Mol Cell Biochem 2014; 393: 177-180.
21. Wallukat G, Schimke I: Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases. Semin Immunopathol 2014; 36: 351-363.
22. Jahns R, Boivin V, Krapf T, Wallukat G, Boege F, Lohse MJ: Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies. J Am Coll Cardiol 2000; 36: 1280-1287.
23. Jahns R, Boivin V, Lohse MJ: Beta(1)-adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy (review). Trends Cardiovasc Med 2006; 16: 20-24.
24. Herda LR, Felix SB, Boege F: Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function. Br J Pharmacol 2012; 166: 847-857.