The First Aptamer-Apheresis Column Specifically for Clearing Blood of β1-Receptor Autoantibodies - A Successful Proof of Principle Using Autoantibody-Positive SHR Rats -

Circulation Journal

Volumn 76, Issue 10, 2012, Pages 2449-2455

  Wallukat, Gerd ^a,b   Haberland, Annekathrin ^c   Berg, Sabine ^d   Schulz, Angela ^c   Freyse, Ernst Joachim ^d   Dahmen, Claudia ^b   Kage, Andreas ^b   Dandel, Michael ^e   Vetter, Roland ^c   Salzsieder, Eckhard ^d   Kreutz, Reinhold ^c   Schimke, Ingolf ^c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b AptaRes AG   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d Institut fur Diabetes 'Gerhardt Katsch'   (Germany)

^e DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Apheresis; Aptamer; Autoantibody; Dilated cardiomyopathy; Immunoadsorption

Indexed keywords

APTAMER; AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR; IMMUNOGLOBULIN G; MUSCARINIC M2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APHERESIS; ARTICLE; BIOASSAY; BODY WEIGHT; CATHETER; CONTROLLED STUDY; EXTRACORPOREAL CIRCULATION; MALE; NEWBORN; NONHUMAN; PLASMA; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; APTAMERS, NUCLEOTIDE; AUTOANTIBODIES; BLOOD COMPONENT REMOVAL; CARDIOMYOPATHIES; IMMUNOSORBENTS; PROTEIN STRUCTURE, SECONDARY; RABBITS; RATS, INBRED SHR; RECEPTOR, MUSCARINIC M2; RECEPTORS, ADRENERGIC, BETA-1;

EID: 84863872030     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-12-0212     Document Type: Article

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