Neutralization of pathogenic beta1-receptor autoantibodies by aptamers in vivo: The first successful proof of principle in spontaneously hypertensive rats

Molecular and Cellular Biochemistry

Volumn 393, Issue 1-2, 2014, Pages 177-180

  Haberland, Annekathrin ^a   Wallukat, Gerd ^b   Berg, Sabine ^c   Schulz, Angela Martina ^a   Freyse, Ernst Joachim ^c   Vetter, Roland ^a   Salzsieder, Eckhard ^c   Müller, Johannes ^d   Kreutz, Reinhold ^a   Schimke, Ingolf ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c Institut fur Diabetes 'Gerhardt Katsch'   (Germany)

^d Berlin Heals UG   (Germany)

Author keywords

Aptamer; Autoantibody; Beta1 receptor; Cardiomyopathy; Heart failure

Indexed keywords

APTAMER; AUTOANTIBODY; BETA1 RECEPTOR AUTOANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; BETA 1 ADRENERGIC RECEPTOR;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; DRUG HALF LIFE; IN VIVO STUDY; NONHUMAN; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; ANIMAL; CARDIOMYOPATHY, DILATED; DRUG EFFECTS; GENETICS; HUMAN; IMMUNOLOGY; PATHOLOGY;

ANIMALS; APTAMERS, NUCLEOTIDE; AUTOANTIBODIES; CARDIOMYOPATHY, DILATED; HUMANS; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC, BETA-1;

EID: 84903471111     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2057-8     Document Type: Article

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