Aptamer neutralization of beta1-adrenoceptor autoantibodies isolated from patients with cardiomyopathies

Circulation Research

Volumn 109, Issue 9, 2011, Pages 986-992

  Haberland, Annekathrin ^a   Wallukat, Gerd ^b,c   Dahmen, Claudia ^c   Kage, Andreas ^c   Schimke, Ingolf ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c AptaRes AG   (Germany)

Author keywords

aptamer; autoantibodies; beta1 adrenoceptor; cardiomyopathy; heart failure

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; APTAMER; AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR; BISOPROLOL; ISOPRENALINE; SINGLE STRANDED DNA;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY ISOLATION; ARTICLE; CARDIAC PATIENT; CHAGAS DISEASE; CHRONOTROPISM; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CYTOTOXICITY; HEART CELL CULTURE; HEART MUSCLE CELL; HUMAN; IN VITRO STUDY; NEWBORN; NONHUMAN; PERIPARTUM CARDIOMYOPATHY; PRIORITY JOURNAL; RAT;

ADRENERGIC BETA-1 RECEPTOR AGONISTS; ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANIMALS; ANTIBODY SPECIFICITY; APOPTOSIS; APTAMERS, NUCLEOTIDE; AUTOANTIBODIES; BISOPROLOL; CARDIOMYOPATHY, DILATED; CELLS, CULTURED; CHAGAS CARDIOMYOPATHY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOPROTERENOL; MYOCYTES, CARDIAC; RATS; RECEPTORS, ADRENERGIC, BETA-1;

EID: 80054978948     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.253849     Document Type: Article

References (28)

1. Marquis JK, Grindel JM. Toxicological evaluation of oligonucleotide therapeutics. Curr Opin Mol Ther. 2000;2:258-263. (Pubitemid 30435995)
2. Keefe AD, Schaub RG. Aptamers as candidate therapeutics for cardiovascular indications. Curr Opin Pharmacol. 2008;8:147-152.
3. Bouchard PR, Hutabarat RM, Thompson KM. Discovery and development of therapeutic aptamers. Annu Rev Pharmacol Toxicol. 2010;50: 237-257.
4. Keefe AD, Pai S, Ellington A. Aptamers as therapeutics. Nature Rev. 2010;9:537-550.
5. Nitsche A, Kurth A, Dunkhorst A, Pänke O, Sielaff H, Junge W, Muh D, Scheller F, Stöcklein W, Dahmen C, Pauli G, Kage A. One-step selection of vaccinia virus-binding DNA aptamers by Monolex. BMC Biotechnology. 2007;7:48.
6. Caforio AL, Mahon NJ, Tona F, McKenna WJ. Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance. Eur J Heart Fail. 2002;4:411-417. (Pubitemid 36564958)
7. Wallukat G, Muñoz Saravia SG, Haberland A, Bartel S, Araujo R, Valda G, Duchen D, Diaz Ramirez I, Borges AC, Schimke I. Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients. J Am Coll Cardiol. 2010; 55:463-468.
8. Forster OAEM. Peripartum cardiomyopathy-an autoimmune disease? Thesis, Faculty of Health Sciences 2007, Univ. Witwatersrand, Johannesburg, South Africa.
9. Wallukat G, Nissen E, Müller J, Brinckmann R, Schimke I, Kunze R. The pathophysiological role of autoantibodies directed to G-protein coupled receptors and therapeutic strategies of antibody removal In: Brinckmann R, Kunze R (eds) G-protein coupled receptors and autoantibodies. Affina Academy, Periodical of the Affina Academy, 2002; Vol. 1,1, Pabst Science Publishers, Lengerich, Germany.
10. Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertel G, Lohse MJ. Direct evidence for a ß1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest. 2004;113: 1419-1429. (Pubitemid 39071697)
11. Müller J, Wallukat G, Dandel M, Bieda H, Brandes K, Spiegelsberger S, Nissen E, Kunze R, Hetzer R. Immunglobulin adsorption in patients with idiopathic dilated cardiomyopathy. Circulation. 2000;101:385-391. (Pubitemid 30067394)
12. Wallukat G, Reinke P, Dörffel WV, Luther HP, Bestvater K, Felix SB, Baumann G. Removal of autoantibodies in dilated cardiomyopathy by immunadsorption. Int J Cardiol. 1996;54:191-195. (Pubitemid 26188306)
13. Dörffel WV, Felix SB, Wallukat G, Brehme S, Bestvater K, Hofmann T, Kleber FX, Baumann G, Reinke P. Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathy. Circulation. 1997;95: 1994-1997. (Pubitemid 27184263)
14. Hessel FP, Wegner C, Müller J, Glaveris C, Wasem J. Economic evaluation and survival analysis of immunoglobulin adsorption in patients with idiopathic dilated cardiomyopathy. Eur J Health Econ. 2004;5: 58-63. (Pubitemid 38315899)
15. Dörffel WV, Wallukat G, Dörffel Y, Felix SB, Baumann G. Immunoadsorption in idiopathic dilated cardiomyopathy, a 3-year follow-up. Int J Cardiol. 2004;97:529-534. (Pubitemid 39550706)
16. Labovsky V, Smulski CR, Gömez K, Levy G, Levin MJ. Anti-beta 1-adrenergic receptor autoantibodies in patients with chronic Chagas heart disease. Clin Exp Immunol. 2007;148:440-449. (Pubitemid 46701041)
17. Deubner N, Berliner D, Schlipp A, Gelbrich G, Caforio AL, Felix SB, Fu M, Katus H, Angermann CE, Lohse MJ, Ertl G, Störk S, Jahns R, Etiology, Titre-Course, and Survival-Study Group. Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study. Eur J Heart Fail. 2010;12:753-762.
18. VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial Group, Chakravarthy U, Adamis AP, Cunningham ET Jr., Goldbaum M, Guyer DR, Katz B, Patel M. Year 2 efficacy results of 2 randomized controlled clinical trials of pegaptanib for neovascular agerelated macular degeneration. Ophthalmology. 2006;113:1508.e1-e25.
19. Hwang B, Han K, Lee SW. Prevention of passively transferred experimental autoimmune myasthenia gravis by an in vitro selected RNA aptamer. FEBS Lett. 2003;548:85-89. (Pubitemid 37281255)
20. Staudt A, Eichler P, Trimpert C, Felix SB, Greinacher A. Fc(gamma) receptors IIa on cardiomyocytes and their potential functional relevance in dilated cardiomyopathy. J Am Coll Cardiol. 2007;49:1684-1692. (Pubitemid 46589923)
21. Jane-wit D, Altuntas CZ, Johnson JM, Yong S, Wickley PJ, Clark P, Wang Q, Popović ZB, Penn MS, Damron DS, Perez DM, Tuohy VK. Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. Circulation. 2007;116:399-410. (Pubitemid 47196545)
22. Magnusson Y, Hjalmarson A, Hoebeke J. ß1-Adrenoceptor autoimmunity in cardiomyopathy. Int J Cardiol. 1996;54:137-141.
23. Medei EH, Nascimento JH, Pedrosa RC, Barcellos L, Masuda MO, Sicouri S, Elizari MV, de Carvalho AC. Antibodies with beta-adrenergic activity from chronic chagasic patients modulate the QT interval and M cell action potential duration. Europace. 2008;10:868-876. (Pubitemid 351882074)
24. Wallukat G, Müller J, Hetzer R. Specific removal off 1-adrenergic auto antibodies from patients with idiopathic dilated cardiomyopathy. N Engl J Med. 2002;347:1806. (Pubitemid 35375628)
25. Rönspeck W, Kunze R, Wallukat G. Peptide gegen DCM hervorrufende Autoantikörper. 19.10.2006, EP1214350.
26. Jahns R, Lohse M. 1-Adrenoceptor-antikörper inhibierende, mutierte, doppelt cyclisierte Rezeptorpeptide. 05.08.2010, EP 2 197 900 A2.
27. Wallukat G, Podlowski S, Nissen E, Morwinski R, Csonka C, Tosaki A, Blasig IE. Functional and structural characterization of anti-ß1- adrenoceptor autoantibodies of spontaneously hypertensive rats. Mol Cell Biochem. 2003;251:67-75. (Pubitemid 37220711)
28. Ferrari I, Levin MJ, Wallukat G, Elies R, Lebesgue D, Chiale P, Elizari M, Rosenbaum M, Hoebeke J. Molecular mimicry between the immunodominant ribosomal protein P0 of Trypanosoma cruzi and a functional epitope on the human beta 1-adrenergic receptor. J Exp Med. 1995;182:59-65.