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Volumn 17, Issue 10, 2016, Pages 856-865

Targeting cancer with epi-drugs: A precision medicine perspective

Author keywords

Cancer epigenomics; Cancer therapy; Epi drugs; Epigenetic memory; Precision medicine; Translational medicine

Indexed keywords

2 DEOXY 5 AZACYTIDINE (3 5) 2 DEOXYGUANOSINE SODIUM; AZACITIDINE; BELINOSTAT; CAS 9 PROTEIN; CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; DECITABINE; DNA METHYLTRANSFERASE INHIBITOR; GIVINOSTAT; HISTONE DEACETYLASE INHIBITOR; PACLITAXEL; PANOBINOSTAT; PROTEIN E6; PROTEIN E7; ROMIDEPSIN; ST7612AA1; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; VEMURAFENIB; VORINOSTAT; ZINC FINGER NUCLEASE; ANTINEOPLASTIC AGENT;

EID: 84978272015     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/1381612822666160527154757     Document Type: Article
Times cited : (11)

References (69)
  • 2
    • 84867783393 scopus 로고    scopus 로고
    • The role of DNA methylation in the pathogenesis and treatment of cancer
    • Peedicayil, J. The role of DNA methylation in the pathogenesis and treatment of cancer. Curr. Clin. Pharmacol., 2012, 7, 333-340.
    • (2012) Curr. Clin. Pharmacol. , vol.7 , pp. 333-340
    • Peedicayil, J.1
  • 3
    • 84930868061 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in hematological malignancies and solid tumors
    • Chun, P. Histone deacetylase inhibitors in hematological malignancies and solid tumors. Arch. Pharm. Res., 2015, 38, 933-949.
    • (2015) Arch. Pharm. Res , vol.38 , pp. 933-949
    • Chun, P.1
  • 4
    • 84931476354 scopus 로고    scopus 로고
    • Chromatin memory in the development of human cancers
    • Yao, Y.; Des Marais, T.L.; Costa, M. Chromatin memory in the development of human cancers. Gene Technol., 2014, 3, 114.
    • (2014) Gene Technol. , vol.3 , pp. 114
    • Yao, Y.1    Des Marais, T.L.2    Costa, M.3
  • 5
    • 84869059680 scopus 로고    scopus 로고
    • DNA hypomethylation and hemimethylation in cancer
    • Ehrlich, M.; Lacey, M. DNA hypomethylation and hemimethylation in cancer. Adv. Exp. Med. Biol., 2013, 754, 31-56.
    • (2013) Adv. Exp. Med. Biol. , vol.754 , pp. 31-56
    • Ehrlich, M.1    Lacey, M.2
  • 6
    • 84886099830 scopus 로고    scopus 로고
    • Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
    • Plass, C.; Pfister, S.M.; Lindroth, A.M.; Bogatyrova, O.; Claus, R.; Lichter, P. Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nat. Rev. Genet., 2013, 14, 765-780.
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 765-780
    • Plass, C.1    Pfister, S.M.2    Lindroth, A.M.3    Bogatyrova, O.4    Claus, R.5    Lichter, P.6
  • 7
    • 77950841042 scopus 로고    scopus 로고
    • Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs
    • Malecova, B.; Morris, K.V. Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs. Curr. Opin. Mol. Ther., 2010, 12, 214-222.
    • (2010) Curr. Opin. Mol. Ther. , vol.12 , pp. 214-222
    • Malecova, B.1    Morris, K.V.2
  • 10
    • 84893046921 scopus 로고    scopus 로고
    • Enhancer RNAs: The new molecules of transcription
    • Lai, F.; Shiekhattar, R. Enhancer RNAs: The new molecules of transcription. Curr. Opin. Genet. Dev., 2014, 25, 38-42.
    • (2014) Curr. Opin. Genet. Dev. , vol.25 , pp. 38-42
    • Lai, F.1    Shiekhattar, R.2
  • 11
    • 80052815461 scopus 로고    scopus 로고
    • Noncoding RNAs and enhancers: Complications of a long-distance relationship
    • Orom, U.A.; Shiekhattar, R. Noncoding RNAs and enhancers: Complications of a long-distance relationship. Trends Genet., 2011, 27, 433-439.
    • (2011) Trends Genet. , vol.27 , pp. 433-439
    • Orom, U.A.1    Shiekhattar, R.2
  • 12
    • 84864553255 scopus 로고    scopus 로고
    • Pre-mRNA splicing: Role of epigenetics and implications in disease
    • Khan, D.H.; Jahan, S.; Davie, J.R. Pre-mRNA splicing: Role of epigenetics and implications in disease. Adv. Biol. Regul., 2012, 52, 377-388.
    • (2012) Adv. Biol. Regul. , vol.52 , pp. 377-388
    • Khan, D.H.1    Jahan, S.2    Davie, J.R.3
  • 13
    • 84869052718 scopus 로고    scopus 로고
    • Cis-acting noncoding RNAs: Friends and foes
    • Guil, S.; Esteller, M. Cis-acting noncoding RNAs: Friends and foes. Nat. Struct. Mol. Biol., 2012, 19, 1068-1075.
    • (2012) Nat. Struct. Mol. Biol. , vol.19 , pp. 1068-1075
    • Guil, S.1    Esteller, M.2
  • 14
    • 84897709311 scopus 로고    scopus 로고
    • Epigenetic inheritance of cell fates during embryonic development
    • Cheedipudi, S.; Genolet, O.; Dobreva, G. Epigenetic inheritance of cell fates during embryonic development. Front Genet., 2014, 5, 19.
    • (2014) Front Genet. , vol.5 , pp. 19
    • Cheedipudi, S.1    Genolet, O.2    Dobreva, G.3
  • 16
    • 84878441552 scopus 로고    scopus 로고
    • Epigenetic memory in the context of nuclear reprogramming and cancer
    • Halley-Stott, R.P.; Gurdon, J.B. Epigenetic memory in the context of nuclear reprogramming and cancer. Br. Funct. Genomics, 2013, 12, 164-173.
    • (2013) Br. Funct. Genomics , vol.12 , pp. 164-173
    • Halley-Stott, R.P.1    Gurdon, J.B.2
  • 17
    • 70449870489 scopus 로고    scopus 로고
    • Covalent modifications of histones during mitosis and meiosis
    • Xu, D.; Bai, J.; Duan, Q.; Costa, M.; Dai, W. Covalent modifications of histones during mitosis and meiosis. Cell Cycle, 2009, 8, 3688-3694.
    • (2009) Cell Cycle , vol.8 , pp. 3688-3694
    • Xu, D.1    Bai, J.2    Duan, Q.3    Costa, M.4    Dai, W.5
  • 18
    • 33646371709 scopus 로고    scopus 로고
    • Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drugresistant tumors: Current views and new therapeutic prospective
    • Roberti, A.; La Sala, D.; Cinti, C. Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drugresistant tumors: Current views and new therapeutic prospective. J. Cell Physiol., 2006, 207, 571-581.
    • (2006) J. Cell Physiol. , vol.207 , pp. 571-581
    • Roberti, A.1    La Sala, D.2    Cinti, C.3
  • 19
    • 0035819032 scopus 로고    scopus 로고
    • Human embryonic genes re-expressed in cancer cells
    • Monk, M.; Holding, C. Human embryonic genes re-expressed in cancer cells. Oncogene, 2001, 20, 8085-8091.
    • (2001) Oncogene , vol.20 , pp. 8085-8091
    • Monk, M.1    Holding, C.2
  • 20
    • 77957757417 scopus 로고    scopus 로고
    • A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
    • Kim, J.; Woo, A.J.; Chu, J.; Snow, J.W.; Fujiwara, Y.; Kim, C.G.; Cantor, A.B.; Orkin, S.H. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell, 2010, 143, 313-324.
    • (2010) Cell , vol.143 , pp. 313-324
    • Kim, J.1    Woo, A.J.2    Chu, J.3    Snow, J.W.4    Fujiwara, Y.5    Kim, C.G.6    Cantor, A.B.7    Orkin, S.H.8
  • 21
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath, I.; Thomson, M.W.; Carey, V.J.; Ge, R.; Bell, G.W.; Regev, A.; Weinberg, R.A. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet., 2008, 40, 499-507.
    • (2008) Nat. Genet. , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 22
    • 84887456252 scopus 로고    scopus 로고
    • The epigenetics of epithelialmesenchymal plasticity in cancer
    • Tam, W.L.; Weinberg, R.A. The epigenetics of epithelialmesenchymal plasticity in cancer. Nat. Med., 2013, 19, 1438-1449.
    • (2013) Nat. Med. , vol.19 , pp. 1438-1449
    • Tam, W.L.1    Weinberg, R.A.2
  • 23
    • 84875745673 scopus 로고    scopus 로고
    • Interplay between the cancer genome and epigenome
    • Shen, H.; Laird, P.W. Interplay between the cancer genome and epigenome. Cell, 2013, 153, 38-55.
    • (2013) Cell , vol.153 , pp. 38-55
    • Shen, H.1    Laird, P.W.2
  • 25
    • 84900298925 scopus 로고    scopus 로고
    • Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines
    • El Baroudi, M.; La Sala, D.; Cinti, C.; Capobianco, E. Pathway landscapes and epigenetic regulation in breast cancer and melanoma cell lines. Theor. Biol. Med. Model., 2014, 11(1), 8.
    • (2014) Theor. Biol. Med. Model. , vol.11 , Issue.1 , pp. 8
    • El Baroudi, M.1    La Sala, D.2    Cinti, C.3    Capobianco, E.4
  • 27
    • 84910029427 scopus 로고    scopus 로고
    • Pan-cancer patterns of DNA methylation
    • Witte, T.; Plass, C.; Gerhauser, C. Pan-cancer patterns of DNA methylation. Genome Med., 2014, 6, 66.
    • (2014) Genome Med. , vol.6 , pp. 66
    • Witte, T.1    Plass, C.2    Gerhauser, C.3
  • 28
    • 84856230176 scopus 로고    scopus 로고
    • Enhancement of chemotherapeutic efficacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b
    • Sandhu, R.; Rivenbark, A.G.; Coleman, W.B. Enhancement of chemotherapeutic efficacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b. Breast Cancer Res. Treat., 2012, 131, 385-399.
    • (2012) Breast Cancer Res. Treat. , vol.131 , pp. 385-399
    • Sandhu, R.1    Rivenbark, A.G.2    Coleman, W.B.3
  • 29
    • 68049116936 scopus 로고    scopus 로고
    • DNA methyltransferase-mediated transcriptional silencing in malignant glioma: A combined wholegenome microarray and promoter array analysis
    • Foltz, G.; Yoon, J.G.; Lee, H.; Ryken, T.C.; Sibenaller, Z.; Ehrich, M.; Hood, L.; Madan, A. DNA methyltransferase-mediated transcriptional silencing in malignant glioma: A combined wholegenome microarray and promoter array analysis. Oncogene, 2009, 28, 2667-2677.
    • (2009) Oncogene , vol.28 , pp. 2667-2677
    • Foltz, G.1    Yoon, J.G.2    Lee, H.3    Ryken, T.C.4    Sibenaller, Z.5    Ehrich, M.6    Hood, L.7    Madan, A.8
  • 31
    • 84945968769 scopus 로고    scopus 로고
    • Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis
    • Kim, H.S.; Shen, Q.; Nam, S.W. Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis. J. Korean Med. Sci., 2015, 30, 1375-1380.
    • (2015) J. Korean Med. Sci. , vol.30 , pp. 1375-1380
    • Kim, H.S.1    Shen, Q.2    Nam, S.W.3
  • 32
    • 84880703261 scopus 로고    scopus 로고
    • Docking of a novel DNA methyltransferase inhibitor identified from high-throughput screening: Insights to unveil inhibitors in chemical databases
    • Medina-Franco, J.L.; Yoo, J. Docking of a novel DNA methyltransferase inhibitor identified from high-throughput screening: Insights to unveil inhibitors in chemical databases. Mol. Divers., 2013, 17, 337-344.
    • (2013) Mol. Divers. , vol.17 , pp. 337-344
    • Medina-Franco, J.L.1    Yoo, J.2
  • 33
    • 84867970694 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors in acute myeloid leukemia: Discovery, design and first therapeutic experiences
    • Thomas, X. DNA methyltransferase inhibitors in acute myeloid leukemia: Discovery, design and first therapeutic experiences. Expert Opin. Drug Discov., 2012, 7, 1039-1051.
    • (2012) Expert Opin. Drug Discov. , vol.7 , pp. 1039-1051
    • Thomas, X.1
  • 34
    • 84861164104 scopus 로고    scopus 로고
    • Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: Discovery of a novel DNMT1 inhibitor
    • Yoo, J.; Kim, J.H.; Robertson, K.D.; Medina-Franco, J.L. Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: Discovery of a novel DNMT1 inhibitor. Adv. Protein Chem. Struct. Biol., 2012, 87, 219-247.
    • (2012) Adv. Protein Chem. Struct. Biol. , vol.87 , pp. 219-247
    • Yoo, J.1    Kim, J.H.2    Robertson, K.D.3    Medina-Franco, J.L.4
  • 37
    • 84940858852 scopus 로고    scopus 로고
    • Transcriptional and epigenetic regulation of autophagy in aging
    • Lapierre, L.R.; Kumsta, C.; Sandri, M.; Ballabio, A.; Hansen, M. Transcriptional and epigenetic regulation of autophagy in aging. Autophagy, 2015, 11, 867-880.
    • (2015) Autophagy , vol.11 , pp. 867-880
    • Lapierre, L.R.1    Kumsta, C.2    Sandri, M.3    Ballabio, A.4    Hansen, M.5
  • 38
    • 33947313218 scopus 로고    scopus 로고
    • HDACs, histone deacetylation and gene transcription: From molecular biology to cancer therapeutics
    • Gallinari, P.; Di Marco, S.; Jones, P.; Pallaoro, M.; Steinkühler, C. HDACs, histone deacetylation and gene transcription: From molecular biology to cancer therapeutics. Cell Res., 2007, 17, 195-211.
    • (2007) Cell Res. , vol.17 , pp. 195-211
    • Gallinari, P.1    Di Marco, S.2    Jones, P.3    Pallaoro, M.4    Steinkühler, C.5
  • 41
    • 84929598341 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents
    • Mottamal, M.; Zheng, S.; Huang, T.L.; Wang, G. Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents. Molecules, 2015, 20, 3898-3941.
    • (2015) Molecules , vol.20 , pp. 3898-3941
    • Mottamal, M.1    Zheng, S.2    Huang, T.L.3    Wang, G.4
  • 43
    • 84945485095 scopus 로고    scopus 로고
    • Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin
    • Kuang, Y.; El-Khoueiry, A.; Taverna, P.; Ljungman, M.; Neamati, N. Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin. Mol. Oncol., 2015, 9, 1799-1814.
    • (2015) Mol. Oncol. , vol.9 , pp. 1799-1814
    • Kuang, Y.1    El-Khoueiry, A.2    Taverna, P.3    Ljungman, M.4    Neamati, N.5
  • 45
    • 84938777793 scopus 로고    scopus 로고
    • Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis
    • Huang, Y.-C.; Huang, F.-I.; Mehndiratta, S.; Lai, S.-C.; Liou, J.-P.; Yang, C.-R. Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis. Oncotarget, 2015, 6, 18590-18601.
    • (2015) Oncotarget , vol.6 , pp. 18590-18601
    • Huang, Y.-C.1    Huang, F.-I.2    Mehndiratta, S.3    Lai, S.-C.4    Liou, J.-P.5    Yang, C.-R.6
  • 46
    • 84928317107 scopus 로고    scopus 로고
    • Advancements in the delivery of epigenetic drugs. Expert Opin
    • Cramer, S.A.; Adjei, I.M.; Labhasetwar, V. Advancements in the delivery of epigenetic drugs. Expert Opin. Drug Deliv., 2015, 12, 1501-1512.
    • (2015) Drug Deliv. , vol.12 , pp. 1501-1512
    • Cramer, S.A.1    Adjei, I.M.2    Labhasetwar, V.3
  • 47
    • 84867658694 scopus 로고    scopus 로고
    • Epigenetics advancing personalized nanomedicine in cancer therapy
    • Liu, S. Epigenetics advancing personalized nanomedicine in cancer therapy. Adv. Drug Deliv. Rev., 2012, 64, 1532-1543.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 1532-1543
    • Liu, S.1
  • 48
    • 84908407738 scopus 로고    scopus 로고
    • Nanocarrier mediated delivery of sirna/mirna in combination with chemotherapeutic agents for cancer therapy: Current progress and advances
    • Gandhi, N.S.; Tekade, R.K.; Chougule, M.B. Nanocarrier mediated delivery of sirna/mirna in combination with chemotherapeutic agents for cancer therapy: Current progress and advances. J. Control Release, 2014, 194, 238-256.
    • (2014) J. Control Release , vol.194 , pp. 238-256
    • Gandhi, N.S.1    Tekade, R.K.2    Chougule, M.B.3
  • 49
    • 84929043919 scopus 로고    scopus 로고
    • Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2’-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics
    • Wu, F.L.; Li, R.T.; Yang, M.; Yue, G.F.; Wang, H.Y.; Liu, Q.; Cui, F.B.; Wu, P.Y.; Ding, H.; Yu, L.X.; Qian, X.P.; Liu, B.R. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2’-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett., 2015, 363, 7-16.
    • (2015) Cancer Lett. , vol.363 , pp. 7-16
    • Wu, F.L.1    Li, R.T.2    Yang, M.3    Yue, G.F.4    Wang, H.Y.5    Liu, Q.6    Cui, F.B.7    Wu, P.Y.8    Ding, H.9    Yu, L.X.10    Qian, X.P.11    Liu, B.R.12
  • 50
    • 84926456748 scopus 로고    scopus 로고
    • Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells
    • Li, S.Y.; Sun, R.; Wang, H.X.; Shen, S.; Liu, Y.; Du, X.J.; Zhu, Y.H.; Jun, W. Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells. J. Control. Release, 2015, 205, 7-14.
    • (2015) J. Control. Release , vol.205 , pp. 7-14
    • Li, S.Y.1    Sun, R.2    Wang, H.X.3    Shen, S.4    Liu, Y.5    Du, X.J.6    Zhu, Y.H.7    Jun, W.8
  • 52
    • 79952025755 scopus 로고    scopus 로고
    • Newly engineered magnetic erythrocytes for sustained and targeted delivery of anticancer therapeutic compounds
    • Cinti, C.; Taranta, M.; Naldi, I.; Grimaldi, S. Newly engineered magnetic erythrocytes for sustained and targeted delivery of anticancer therapeutic compounds. PLoS One, 2011, 6, 17132.
    • (2011) Plos One , vol.6
    • Cinti, C.1    Taranta, M.2    Naldi, I.3    Grimaldi, S.4
  • 53
    • 84903843607 scopus 로고    scopus 로고
    • SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells
    • Bu, Q.; Cui, L.; Li, J.; Du, X.; Zou, W.; Ding, K.; Pan, J. SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells. Cancer Biol. Ther., 2014, 15, 951-962.
    • (2014) Cancer Biol. Ther. , vol.15 , pp. 951-962
    • Bu, Q.1    Cui, L.2    Li, J.3    Du, X.4    Zou, W.5    Ding, K.6    Pan, J.7
  • 54
    • 84925680102 scopus 로고    scopus 로고
    • Epigenetic biomarkers in the blood of patients with urological malignancies
    • Ellinger, J.; Muller, S.C.; Dietrich, D. Epigenetic biomarkers in the blood of patients with urological malignancies. Expert Rev. Mol. Diagn., 2015, 15, 505-516.
    • (2015) Expert Rev. Mol. Diagn. , vol.15 , pp. 505-516
    • Ellinger, J.1    Muller, S.C.2    Dietrich, D.3
  • 55
    • 84900371086 scopus 로고    scopus 로고
    • Prostate cancer epigenetic biomarkers: Next-generation technologies
    • Valdes-Mora, F.; Clark, S.J. Prostate cancer epigenetic biomarkers: Next-generation technologies. Oncogene, 2015, 34, 1609-1618.
    • (2015) Oncogene , vol.34 , pp. 1609-1618
    • Valdes-Mora, F.1    Clark, S.J.2
  • 56
    • 84927513082 scopus 로고    scopus 로고
    • Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity
    • Jurkowski, T.P.; Ravichandran, M.; Stepper, P. Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clin Epigenetics, 2015, 7, 18.
    • (2015) Clin Epigenetics , vol.7 , pp. 18
    • Jurkowski, T.P.1    Ravichandran, M.2    Stepper, P.3
  • 57
    • 84923628632 scopus 로고    scopus 로고
    • Epigenome engineering in cancer: Fairytale or a realistic path to the clinic? Front
    • Falahi, F.; Sgro, A.; Blancafort, P. Epigenome engineering in cancer: Fairytale or a realistic path to the clinic? Front. Oncol., 2015, 5, 22.
    • (2015) Oncol. , vol.5 , pp. 22
    • Falahi, F.1    Sgro, A.2    Blancafort, P.3
  • 58
    • 84904768201 scopus 로고    scopus 로고
    • Drug target seqR: A genomics- and CRISPR-Cas9-based method to analyze drug targets
    • Kasap, C.; Elemento, O.; Kapoor, T.M. Drug target seqR: A genomics- and CRISPR-Cas9-based method to analyze drug targets. Nat. Chem. Biol., 2014, 10, 626-628.
    • (2014) Nat. Chem. Biol. , vol.10 , pp. 626-628
    • Kasap, C.1    Elemento, O.2    Kapoor, T.M.3
  • 61
    • 84926640760 scopus 로고    scopus 로고
    • Isolation of specific genomic regions and identification of associated molecules by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (EnChIP) using CRISPR
    • Fujita, T.; Fujii, H. Isolation of specific genomic regions and identification of associated molecules by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) using CRISPR. Methods Mol. Biol., 2015, 1288, 43-52.
    • (2015) Methods Mol. Biol. , vol.1288 , pp. 43-52
    • Fujita, T.1    Fujii, H.2
  • 67
    • 84954363092 scopus 로고    scopus 로고
    • CRISPRCas9 systems: Versatile cancer modelling platforms and promising therapeutic strategies
    • Wen, W.S.; Yuan, Z.M.; Ma, S.J.; Xu, J.; Yuan, D.T. CRISPRCas9 systems: Versatile cancer modelling platforms and promising therapeutic strategies. Int. J. Cancer, 2016, 138, 1328-1336.
    • (2016) Int. J. Cancer , vol.138 , pp. 1328-1336
    • Wen, W.S.1    Yuan, Z.M.2    Ma, S.J.3    Xu, J.4    Yuan, D.T.5


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