Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort

American Journal of Reproductive Immunology

Volumn 76, Issue 2, 2016, Pages 164-171

  Alijotas Reig, Jaume ^a,b   Ferrer Oliveras, Raquel ^a   Esteve Valverde, Enrique ^a,c   Ruffatti, Amelia ^d   Tincani, Angela ^e   Lefkou, Elmina ^f   Bertero, Maria Tiziana ^g   Espinosa, Gerard ^h   Coloma, Emmanuel ^h   de Carolis, Sara ⁱ   Rovere Querini, Patrizia ^j   Canti, Valentina ^j,k   Picardo, Elisa ^l   Fredi, Micaela ^e   Mekinian, Arsene ^m   Kuzenko, Anna ⁿ   Ruano, Anna ⁿ   del Ross, Teresa ⁿ   Melnychuk, Taisiia ⁿ   Lundelin, Krista ⁿ   Llurba, Elisa ⁿ   Cervera, Ricard ⁿ   Toth, Bettina ⁿ   Saez Comet, Luis ⁿ   Bremme, Katharina ⁿ   Mayer Pickel, Karoline ⁿ   Gil Aguado, Antonio ⁿ   more..

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c Althaia   (Spain)

^d UNIVERSITY OF PADOVA   (Italy)

^e Ospedale Civile   (Italy)

^f Aristotle University Medical School   (Greece)

^g MAURIZIANO HOSPITAL   (Italy)

^h UNIVERSITY OF BARCELONA   (Spain)

ⁱ CATHOLIC UNIVERSITY   (Italy)

^j VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^k Laboratorio Autoimmunità e Inflammazione Voscolare San Raffaele DIBIT   (Italy)

^l UNIVERSITY OF TURIN   (Italy)

^m HÔPITAL SAINT ANTOINE   (France)

ⁿ NONE

more..

Author keywords

antiphospholipid antibody; inherited thrombophilia; obstetric outcome; thrombosis; treatment

Indexed keywords

LOW MOLECULAR WEIGHT HEPARIN;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; DISEASE ASSOCIATION; FEMALE; HUMAN; INHERITED THROMBOPHILIC DISORDER; MAJOR CLINICAL STUDY; MATERNAL DISEASE; MORBIDITY; OBSTETRIC ANTIPHOSPHOLIPID SYNDROME; OBSTETRIC MORBIDITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; THROMBOPHILIA;

EID: 84978229544     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12534     Document Type: Article

References (34)

1. Antiphospholipid syndrome. ACOG Practice Bulletin. Obstet Gynecol. 2012;120:1514–1521.
2. Alijotas-Reig J, Ferrer-Oliveras R; EUROAPS Study Group. The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): a preliminary first year report. Lupus. 2012;21:766–768.
3. Out HJ, Kooijman CD, Bruinse HW, Derksen RH. Histopathological findings in placentae from patients with intra-uterine fetal death and antiphospholipid antibodies. Eur J Obstet Gynaecol Reprod Biol. 1991;195:211–220.
4. Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid-induced fetal loss by inhibiting complement activation. Nat Med. 2004;10:1222–1226.
5. Carbone J, Sarmiento E, Rodriguez-Molina J, Fernandez-Cruz E. Hipocomplementemia C3 y C4 en el síndrome antifosfolípido obstétrico. Rev Clin Esp. 2008;208:168–171.
6. Salmon JE, Girardi G. Antiphospholipid syndrome revisited: a disorder initiated by inflammation. Lupus. 2007;16(abst suppl):1–2.
7. Berman J, Girardi G, Salmon JE. TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss. J Immunol. 2005;174:1222–1226.
8. Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med. 2006;203:2165–2175.
9. Erkan D, Merrill JT, Loskshin MD, Sammaritano L, Buyon JP, Lockshin MD. High thrombosis rate after fetal loss in antiphospholipid syndrome effective prophylaxis with aspirin. Arthritis Rheum. 2001;44:1466–1467.
10. Finazzi G, Brancaccio V, Moia M, et al. Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies: a four-year prospective study from the Italian registry. Am J Med. 1996;100:530–536.
11. Quenby S, Farquharson RG, Dawood F, Hughes AM, Topping J. Recurrent miscarriage and long-term thrombosis risk: a case-control study. Hum Reprod. 2005;20:1729–1732.
12. Castro-Marrero J, Balada E, Vilardell-Tarres M, Ordi-Ros J. Genetic risk factors of thrombosis in the antiphospholipid syndrome. Br J Haematol. 2009;147:289–296.
13. Berman H, Ugarte M, Espinosa G, et al. Can inherited thrombophilia modulate the clinical phenotype of patients with antiphospholipid syndrome? Clin Exp Rheumatol. 2013;31:926–932.
14. Branch W. Obstetric task force report of the obstetric APS task force: 13th international congress on antiphospholipid antibodies, 13th April 2010. Lupus. 2011;20:158–164.
15. Alijotas-Reig J, Vilardell-Tarres M. Is obstetric antiphospholipid syndrome a primary nonthrombotic, proinflammatory, complement-mediated disorder related to antiphospholipid antibodies? Obstet Gynecol Surv. 2010;65:39–45.
16. Levy RA, Jesus GRR, Jesus NR. Obstetric antiphospholipid syndrome: still a challenge. Lupus. 2010;19:457–459.
17. Brouwer JL, Bijl M, Veeger NJ, Kluin-Nelemans HC, van der Meer J. The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus. Blood. 2004;104:43–147.
18. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. J Thromb Haemost. 2006;4:205–306.
19. Wilson WA, Gharavi AE, Koike T, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum. 1999;42:1309–1311.
20. Yamada H, Atsumi T, Kato EH, Shimada S, Morikawa M, Minakami H. Prevalence of diverse antiphospholipid antibodies in women with recurrent spontaneous abortion. Fertil Steril. 2003;80:1276–1278. 1310.
21. Bouvier S, Cochery-Nouvellon E, Gris JC, et al. Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study. Blood. 2014;123:404–412.
22. Galarza-Maldonado C, Kourilovitch MR, Perez-Fernandez O, et al. Obstetric antiphospholipid syndrome. Autoimmun Rev. 2012;11:288–295.
23. de Jesus GR, Agmon-Levin N, Andrade Carlos A, et al. 14th international congress on antiphospholipid antibodies task force report on obstetric antiphospholipid syndrome. Autoimmun Rev. 2014;13:795–813.
24. Mekinian A, Loire-Berson P, Nicaise-Roland P, et al. Outcomes and treatment of obstetrical antiphospholipid syndrome in women with low antiphospholipid antibody levels. J Reprod Immunol. 2012;94:222–226.
25. Diz-Kucukkaya R, Hancer VS, Artim-Esen B, Pekcelen Y, Inanc M. The prevalence and clinical significance of inherited thrombophilic risk factors in patients with antiphospholipid syndrome. J Thromb Thrombolysis. 2010;29:303–309.
26. Forastiero R, Martinuzzo M, Adamczuk Y, Varela ML, Pombo G, Carreras LO. The combination of thrombophilic genotypes is associated with definite antiphospholipid síndrome. Haematologica. 2001;86:735–741.
27. Galli M, Finazzi G, Duca F, Norbis F, Moia M. The G1691 –> A mutation of factor V, but not the G20210 –> A mutation of factor II or the C677 –> T mutation of methylenetetrahydrofolate reductase genes, is associated with venous thrombosis in patients with lupus anticoagulants. Br J Haematol. 2000;108:865–870.
28. Wong LF, Porter TF, de Jesus GR. Recurrent early pregnancy loss and antiphospholipid antibodies: where do we stand? Lupus. 2014;23:1226–1228.
29. Abou-Nassar K, Carrier M, Ramsay T, Rodger MA. The association between antiphospholipid antibodies and placenta-mediated complications: a systematic review and meta-analysis. Thromb Res. 2011;128:77–85.
30. Silver RM, Parker CB, Reddy UM, et al. Antiphospholipid antibodies and stillbirth. Obstet Gynecol. 2013;122:641–657.
31. Alijotas Reig J. Towards the comprehension of heterogeneity of clinical manifestations related to antiphospholipid antibodies. Med Clin (Barc). 2005;125:187–189.
32. Devereese KM. Antiphospholipid antibodies: evaluation of the thrombotic risk. Thromb Res. 2012;130:S37–S40.
33. Boffa MC, Boinot C, De Carolis S, et al. Laboratory criteria of the obstetrical antiphospholipid syndrome (APS). Data from a multicentric prospective European women cohort. Thromb Haemost. 2009;102:25–28.
34. Ruffatti A, Salvan E, Del Ross T, et al. Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. A European multicentre retrospective study. Thromb Haemost. 2014;112:727–735.