C3 and C4 hypocomplementemia in obstetric antiphospholipid syndrome;Hipocomplementemia C3 y C4 en el síndrome antifosfolípido obstétrico

Revista Clinica Espanola

Volumn 208, Issue 3, 2008, Pages 170-171

  Carbone, J ^a   Sarmiento, E ^a   Rodriguez Molina J ^a   Fernandez Cruz E ^a  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4;

ANTIPHOSPHOLIPID SYNDROME; HUMAN; HYPOCOMPLEMENTEMIA; LETTER; PREGNANCY;

EID: 42549135652     PISSN: 00142565     EISSN: 15781860     Source Type: Journal    
DOI: 10.1157/13115833     Document Type: Letter

References (9)

1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295-306.
2. Harris EN, Gharavi AE, Boey ML, Patel BM, Mackworth-Young CG, Loizou S, et al. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet. 1983;2(8361):1211-4.
3. Girardi G, Salmon JB. The role of complement in pregnancy and fetal loss. Autoimmunity. 2003;36:19-26.
4. Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med. 2006;203:2165-75.
5. Shamonki JM, Salmon JE, Hyjek E, Baergen RN. Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies. Am J Obstet Gynecol. 2007;196:167.e1-5.
6. Weiler JM, Yurt RW, Fearon DT, Austen KF. Modulation of the formation of the amplification convertase of complement, C3b, Bb, by native and commercial heparin. J Exp Med. 1978;147:409-21.
7. Girardi G. Heparin treatment in pregnancy loss: Potential therapeutic benefits beyond anticoagulation. J Reprod Immunol. 2005;66:45-51.
8. Carbone J, Orera M, Rodríguez-Mahou M, Rodríguez- Pérez C, Sánchez Ramon S, Seoane E, et al. Immunological abnormalities in primary APS evolving into SLE: 6 years follow-up in women with repeated pregnancy loss. Lupus. 1999;8:274-8.
9. Ramos-Casals M, Campoamor MT, Chamorro A, Salvador G, Segura S, Botero JC, et al. Hypocomplementemia in systemic lupus erythematosus and primary antiphospholipid syndrome: prevalence and clinical significance in 667 patients. Lupus. 2004;13:777-83.