The combination of thrombophilic genotypes is associated with definite antiphospholipid syndrome

Haematologica

Volumn 86, Issue 7, 2001, Pages 735-741

  Forastiero, R ^a   Martinuzzo, M ^a   Adamczuk, Y ^a   Iglesias Varela, M L ^a   Pombo, G ^a   Carreras, L O ^a  

^a FAVALORO UNIVERSITY   (Argentina)

Author keywords

Antiphospholipid antibodies; Antiphospholipid syndrome; Thrombophilia; Thrombosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; PHOSPHOLIPID ANTIBODY; PLASMINOGEN ACTIVATOR INHIBITOR; PROTHROMBIN;

ADOLESCENT; ADULT; AGED; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; THROMBOPHILIA; THROMBOSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; CASE-CONTROL STUDIES; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PREGNANCY; PREVALENCE; THROMBOPHILIA;

EID: 0034917638     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an international workshop
2. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease
3. Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C
4. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
5. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
6. Interaction between hyperhomocysteinemia and inherited thrombophilic factors in venous thromboembolism
7. The 4G/5G sequence polymorphism in the promoter of plasminogen activator inhibitor-1 (PAI-1) gene: Relationship to plasma PAI-1 level in venous thromboembolism
8. Risk factors for venous thrombotic disease
9. Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: Prevalence and risk assessment
10. Factor V Leiden, antiphospholipid antibodies and thrombosis in systemic lupus erythematosus
11. Lack of association between thrombosis in primary antiphospholipid syndrome and the recently described thrombophilic 3′-untranslated prothrombin gene polymorphism
12. Prothrombin mutation is not associated with thrombosis in patients with antiphospholipid syndrome
13. Thrombophilic genotypes in subjects with idiopathic antiphospholipid antibodies: Prevalence and significance
14. The 4G/5G polymorphism of the type 1 plasminogen activator inhibitor gene and thrombosis in patients with antiphospholipid syndrome
15. The G1691→A mutation of factor V, but not the G20210→A mutation of factor II or the C677→T mutation of methylenetetrahydrofolate reductase genes, is associated with venous thrombosis in patients with lupus anticoagulants
16. Evaluation of recently described tests for detection of the lupus anticoagulant
17. 2 glycoprotein I and anti prothrombin antibodies to thrombosis and pregnancy loss in patients with antiphospholipid antibodies
18. Criteria for the diagnosis of lupus anticoagulants: An update
19. Special report
20. Rapid detection of the prothrombin 20210 A variation by allele specific PCR
21. 4G/5G polymorphism of PAI-1 gene promoter and fibrinolytic capacity in patients with deep vein thrombosis
22. Pathogenic role of antiprotein-phospholipid antibodies
23. Immunology of the antiphospholipid antibody syndrome
24. Factor V Leiden and prothrombin G20210A variant are risk factors for venous thromboembolism in the Argentinean population
25. The factor V Leiden mutation which predisposes to thrombosis is not common in patients with antiphospholipid syndrome
26. 2 glycoprotein I antibodies
27. The impact of the search for thrombophilia risk factors among antiphospholipid syndrome patients with thrombosis
28. Inherited thrombophilia and pregnancy loss
29. Autoimmune thrombophilic syndromes
30. G20210A homozygosity in antiphospholipid syndrome secondary to systemic lupus erythematosus