Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats

Journal of Ethnopharmacology

Volumn 192, Issue , 2016, Pages 20-29

  Fang, Junwei ^a   Wang, Wenyu ^b   Sun, Shujun ^a   Wang, Yang ^a   Li, Qianhua ^a   Lu, Xiong ^a   Qiu, Mingfeng ^c   Zhang, Yongyu ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b MacroStat Clinical Research Co Ltd   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

GC MS; Metabolomics; Renal fibrosis; Total aglycone extracts of Scutellaria baicalensis; Unilateral ureteral obstruction

Indexed keywords

AGLYCONE; ARGININE; BIOLOGICAL MARKER; DICARBOXYLIC ACID; FRUCTOSE; GLYCINE; HYDROXYPROLINE; LOSARTAN; MANNOSE; PROLINE; RETINOL; SCUTELLARIA BAICALENSIS EXTRACT; SERINE; THREONINE; TOTAL AGLYCONE EXTRACTS OF SCUTELLARIA BAICALENSIS; UNCLASSIFIED DRUG; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CREATININE; PLANT EXTRACT; URINARY TRACT AGENT;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GAS CHROMATOGRAPHY; GENE EXPRESSION; KIDNEY FIBROSIS; KIDNEY FUNCTION; MALE; MASS SPECTROMETRY; METABOLOMICS; NONHUMAN; PATHOGENESIS; RAT; URETER OBSTRUCTION; ANIMAL; BLOOD; CLASSIFICATION; COMPLICATION; DISCRIMINANT ANALYSIS; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; FIBROSIS; ISOLATION AND PURIFICATION; KIDNEY; KIDNEY DISEASES; MASS FRAGMENTOGRAPHY; MEDICINAL PLANT; METABOLISM; MULTIVARIATE ANALYSIS; PATHOLOGY; PHYTOTHERAPY; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES; SCUTELLARIA BAICALENSIS; TIME FACTOR; UREA NITROGEN BLOOD LEVEL; URETERAL OBSTRUCTION; URINE; WISTAR RAT;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BIOMARKERS; BLOOD UREA NITROGEN; CREATININE; DISCRIMINANT ANALYSIS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROSIS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROXYPROLINE; KIDNEY; KIDNEY DISEASES; LOSARTAN; MALE; METABOLOMICS; MULTIVARIATE ANALYSIS; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PRINCIPAL COMPONENT ANALYSIS; RATS, WISTAR; SCUTELLARIA BAICALENSIS; TIME FACTORS; URETERAL OBSTRUCTION; UROLOGICAL AGENTS;

EID: 84978199989     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.06.014     Document Type: Article

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