A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells

Journal of Pathology

Volumn 236, Issue 3, 2015, Pages 384-394

  Luo, Yongfeng ^a,b   Xu, Wei ^a,b   Chen, Hui ^a   Warburton, David ^a,b   Dong, Rachel ^a,b   Qian, Bangping ^c   Selman, Moisés ^d   Gauldie, Jack ^e   Kolb, Martin ^e   Shi, Wei ^a,b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^d INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

^e MCMASTER UNIVERSITY   (Canada)

Author keywords

collagen prolyl hydroxylase; lung mesenchymal cells; pulmonary fibrosis; TGF signalling

Indexed keywords

COLLAGEN; DOXYCYCLINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; SHORT HAIRPIN RNA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; BLEOMYCIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CASE REPORT; COLLAGEN FIBRIL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FIBROBLAST CULTURE; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENOTYPE; HUMAN; HUMAN TISSUE; HYDROXYLATION; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL; LUNG FIBROBLAST; MALE; MESENCHYME CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSIENT EXPRESSION; UBIQUITINATION; UPREGULATION; WILD TYPE; AGED; ANIMAL; CHEMICALLY INDUCED; ENZYMOLOGY; FIBROBLAST; GENE INACTIVATION; GENETICS; LUNG; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; PATHOLOGY; TRANSGENIC MOUSE;

AGED; ANIMALS; BLEOMYCIN; COLLAGEN; FIBROBLASTS; GENE KNOCKOUT TECHNIQUES; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; LUNG; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, TRANSGENIC; MIDDLE AGED; PROLYL HYDROXYLASES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84930483141     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4530     Document Type: Article

References (33)

1. Ley B, Collard HR, King TE,. Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2011; 183: 431-440.
2. King TE, Bradford WZ, Castro-Bernardini S, et al., A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med 2014; 370: 2083-2092.
3. Richeldi L, du Bois RM, Raghu G, et al., Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med 2014; 370: 2071-2082.
4. Selman M, King TE, Pardo A,. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001; 134: 136-151.
5. King TE, Pardo A, Selman M,. Idiopathic pulmonary fibrosis. Lancet 2011; 378: 1949-1961.
6. Fernandez IE, Eickelberg O,. New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis. Lancet 2012; 380: 680-688.
7. Zhao J, Shi W, Wang YL, et al., Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 2002; 282: L585-593.
8. Bonniaud P, Kolb M, Galt T, et al., Smad3-null mice develop airspace enlargement and are resistant to TGFβ-mediated pulmonary fibrosis. J Immunol 2004; 173: 2099-2108.
9. Sheppard D., Integrin-mediated activation of latent transforming growth factor-β. Cancer Metastasis Rev 2005; 24: 395-402.
10. Li M, Krishnaveni MS, Li C, et al., Epithelium-specific deletion of TGFβ receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest 2011; 121: 277-287.
11. Zhang W, Menke DB, Jiang M, et al., Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer. BMC Biol 2013; 11: 111.
12. Chytil A, Magnuson MA, Wright CV, et al., Conditional inactivation of the TGFβ type II receptor using Cre:Lox. Genesis 2002; 32: 73-75.
13. Frugier T, Koishi K, Matthaei KI, et al., Transgenic mice carrying a tetracycline-inducible, truncated transforming growth factorβ receptor (TβRII). Genesis 2005; 42: 1-5.
14. Perl AK, Wert SE, Nagy A, et al., Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci USA 2002; 99: 10482-10487.
15. Raghu G, Collard HR, Egan JJ, et al., An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 2011; 183: 788-824.
16. Maytal Bivas-Benita RZ, Hans E,. Junginger, Gerrit borchard. non-invasive pulmonary aerosol delivery in mice by the endotracheal route. Eur J Pharmaceut Biopharmaceut 2005: 214-218.
17. Tarantal AF, Chen H, Shi TT, et al., Overexpression of transforming growth factor-β1 in fetal monkey lung results in prenatal pulmonary fibrosis. Eur Respir J 2010; 36: 907-914.
18. Xu W, Lan Q, Chen M, et al., Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. PloS One 2012; 7: e40314.
19. Richards IM, Kolbasa KP, Winterrowd GE, et al., Role of intercellular adhesion molecule-1 in antigen-induced lung inflammation in brown Norway rats. Am J Physiol 1996; 271: L267-276.
20. Ashcroft T, Simpson JM, Timbrell V,. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol 1988; 41: 467-470.
21. Sun J, Chen H, Chen C, et al., Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol 2008; 172: 571-582.
22. Chen H, Sun J, Buckley S, et al., Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol 2005; 288: L683-691.
23. Fujita M, Ye Q, Ouchi H, et al., Doxycycline attenuated pulmonary fibrosis induced by bleomycin in mice. Antimicrob Agents Chemother 2006; 50: 739-743.
24. Van Den Diepstraten C, Papay K, Bolender Z, et al., Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque. Circulation 2003; 108: 508-511.
25. Kukkola L, Hieta R, Kivirikko KI, et al., Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. J Biol Chem 2003; 278: 47685-47693.
26. Myllyharju J., Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol 2003; 22: 15-24.
27. Myllyharju J., Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets. Ann Med 2008; 40: 402-417.
28. Border WA, Noble NA,. Transforming growth factor-β in tissue fibrosis. N Engl J Med 1994; 331: 1286-1292.
29. Kulkarni AB, Huh CG, Becker D, et al., Transforming growth factor-β1-null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993; 90: 770-774.
30. Kisseleva T, Brenner DA,. Mechanisms of fibrogenesis. Exp Biol Med (Maywood) 2008; 233: 109-122.
31. Hoyles RK, Derrett-Smith EC, Khan K, et al., An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor. Am J Respir Crit Care Med 2011; 183: 249-261.
32. Rock JR, Barkauskas CE, Cronce MJ, et al., Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci USA 2011; 108: E1475-1483.
33. Hung C, Linn G, Chow YH, et al., Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med 2013; 188: 820-830.