Diastolic Hypotension, Troponin Elevation, and Electrocardiographic Changes Associated With the Management of Moderate to Severe Asthma in Children

Academic Emergency Medicine

Volumn 23, Issue 7, 2016, Pages 816-822

  Fagbuyi, Daniel B ^a   Venkataraman, Shekhar ^b   Ralphe, J Carter ^c   Zuckerbraun, Noel S ^b   Pitetti, Raymond D ^b   Lin, Yan ^d   Jeong, Kwonho ^e   Saladino, Richard A ^b   Manole, Mioara D ^b  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMINOPHYLLINE; ANTIASTHMATIC AGENT; HELIOX; MAGNESIUM SULFATE; SALBUTAMOL; TERBUTALINE; TROPONIN; TROPONIN I;

ADOLESCENT; ARTICLE; ASTHMA; BLOOD PRESSURE MEASUREMENT; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DESCRIPTIVE RESEARCH; DIASTOLIC BLOOD PRESSURE; DIASTOLIC HYPOTENSION; DISEASE SEVERITY; ELECTROCARDIOGRAM; FEMALE; HELIUM OXYGEN BREATHING; HUMAN; HYPOTENSION; INCIDENCE; MALE; NEBULIZATION; OUTCOME ASSESSMENT; OXYGEN SATURATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; QRS COMPLEX; SIDE EFFECT; ST SEGMENT; ST SEGMENT DEPRESSION;

EID: 84977667831     PISSN: 10696563     EISSN: 15532712     Source Type: Journal    
DOI: 10.1111/acem.12997     Document Type: Article

References (29)

1. Centers for Disease Control and Prevention (CDC). Influenza vaccination coverage among children with asthma–United States, 2004-05 influenza season. MMWR Morb Mortal Wkly Rep 2007;56:193–6.
2. Urbano FL. Review of the NAEPP 2007 Expert Panel Report (EPR-3) on Asthma Diagnosis and Treatment Guidelines. J Manag Care Pharm 2008;14:41–9.
3. Benito-Fernandez J. Short-term clinical outcomes of acute treatment of childhood asthma. Curr Opin Allergy Clin Immunol 2005;5:241–6.
4. Travers A, Jones AP, Kelly K, Barker SJ, Camargo CA, Rowe BH. Intravenous beta2-agonists for acute asthma in the emergency department. Cochrane Database Syst Rev 2001;(2):CD002988.
5. Papo MC, Frank J, Thompson AE. A prospective, randomized study of continuous versus intermittent nebulized albuterol for severe status asthmaticus in children. Crit Care Med 1993;21:1479–86.
6. Katz RW, Kelly HW, Crowley MR, Grad R, McWilliams BC, Murphy SJ. Safety of continuous nebulized albuterol for bronchospasm in infants and children. Pediatrics 1993;92:666–9. Erratum in: Pediatrics 1994;93:A28.
7. Rudnitsky GS, Eberlein RS, Schoffstall JM, Mazur JE, Spivey WH. Comparison of intermittent and continuously nebulized albuterol for treatment of asthma in an urban emergency department. Ann Emerg Med 1993;22:1842–6.
8. National Asthma Education and Prevention Program. National Asthma Education and Prevention Program. Expert Panel Report: Guidelines for the Diagnosis and Management of Asthma Update on Selected Topics–2002. J Allergy Clin Immunol 2002;110:S141–219. Erratum in: J Allergy Clin Immunol 2003;111:466.
9. PDR Guide to Drug Interactions, Side Effects, and Indications. Montvale, NJ: Thomson PDR; 2006:v.
10. Brown-Lukacsko A, Lukacsko P. Beta 2-mediated hypotension and myocardial injury. Can J Physiol Pharmacol 1982;60:1144–8.
11. Sarnaik SM, Saladino RA, Manole M, et al. Diastolic hypotension is an unrecognized risk factor for beta-agonist-associated myocardial injury in children with asthma. Pediatr Crit Care Med 2013;14:e273–9.
12. Cazzola M, Matera MG, Donner CF. Inhaled beta2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung disease. Drugs 2005;65:1595–610.
13. Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest 2004;125:2309–21.
14. Craig VL, Bigos D, Brilli RJ. Efficacy and safety of continuous albuterol nebulization in children with severe status asthmaticus. Pediatr Emerg Care 1996;12:1–5.
15. Fisher AA, Davis MW, McGill DA. Acute myocardial infarction associated with albuterol. Ann Pharmacother 2004;38:2045–9.
16. Kenyon CC, Fieldston ES, Luan X, Keren R, Zorc JJ. Safety and effectiveness of continuous aerosolized albuterol in the non-intensive care setting. Pediatrics 2014;134:e976–82.
17. Qureshi F, Pestian J, Davis P, Zaritsky A. Effect of nebulized ipratropium on the hospitalization rates of children with asthma. N Engl J Med 1998;339:1030–5.
18. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114(2 Suppl 4th Report):555–76.
19. Blumenthal S, Epps RP, Heavenrich R, et al. Report of the task force on blood pressure control in children. Pediatrics 1977;59:I–II, 797–820.
20. Koerbin G, Tate JR, Potter JM, Hickman PE. The comparative analytical performance of four troponin I assays at low concentration. Ann Clin Biochem 2005;42:19–23.
21. Collinson PO, Boa FG, Gaze DC. Measurement of cardiac troponins. Ann Clin Biochem 2001;38:423–49.
22. Chiang VW, Burns JP, Rifai N, Lipshultz SE, Adams MJ, Weiner DL. Cardiac toxicity of intravenous terbutaline for the treatment of severe asthma in children: a prospective assessment. J Pediatr 2000;137:73–7.
23. Kalyanaraman M, Bhalala U, Leoncio M. Serial cardiac troponin concentrations as marker of cardiac toxicity in children with status asthmaticus treated with intravenous terbutaline. Pediatr Emerg Care 2011;27:933–6.
24. Zanoni LZ, Palhares DB, Consolo LC. Myocardial ischemia induced by nebulized fenoterol for severe childhood asthma. Indian Pediatr 2005;42:1013–8.
25. Domenech RJ, MacLellan PR. Transmural ventricular distribution of coronary blood flow during coronary beta 2-adrenergic receptor activation in dogs. Circ Res 1980;46:29–36.
26. Roongsritong C, Warraich I, Bradley C. Common causes of troponin elevations in the absence of acute myocardial infarction: incidence and clinical significance. Chest 2004;125:1877–84.
27. Dasgupta A, Banerjee SK, Datta P. False-positive troponin I in the MEIA due to the presence of rheumatoid factors in serum. Elimination of this interference by using a polyclonal antisera against rheumatoid factors. Am J Clin Pathol 1999;112:753–6.
28. Fleming SM, O'Byrne L, Finn J, Grimes H, Daly KM. False-positive cardiac troponin I in a routine clinical population. Am J Cardiol 2002;89:1212–5.
29. Fitzmaurice TF, Brown C, Rifai N, Wu AH, Yeo KT. False increase of cardiac troponin I with heterophilic antibodies. Clin Chem 1998;44:2212–4.