False increase of cardiac troponin I with heterophilic antibodies

Clinical Chemistry

Volumn 44, Issue 10, 1998, Pages 2212-2214

  Fitzmaurice, Thomas F ^a   Brown, Charles ^a   Rifai, Nader ^b   Wu, Alan H B ^c   Yeo, Kiang Teck J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARTFORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE MB; HETEROPHILE ANTIBODY; TROPONIN I;

AGED; ANALYTICAL ERROR; ARTICLE; CASE REPORT; ENZYME IMMUNOASSAY; HEART INFARCTION; HUMAN; MALE; MICROPARTICLE ENZYME IMMUNOASSAY;

EID: 0031710957     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/44.10.2212     Document Type: Article

References (8)

1. Boscato LM, Stuart MC. Incidence and specificity of interference in two-site immunoassays. Clin Chem 1986;32:1491-5.
2. Boscato LM, Stuart MC. Heterophilic antibodies: a problem for all immunoassays. Clin Chem 1988;34:27-33.
3. Kricka LJ, Schmerfeld-Pruss D, Senior M, Goodman DBP, Kaladas P. Interference by anti-mouse antibody in two-site immunoassays. Clin Chem 1990;36:892-4.
4. Levinson SS. Antibody multispecificity in immunoassay interference. Clin Biochem 1992;25:77-87.
5. Ward G, McKinnon L, Badrick T, Hickman PE. Heterophilic antibodies remain a problem for the immunoassay laboratory. Am J Clin Pathol 1997;108:417-21.
6. Boerman OC, Segers MFG, Poels LG, Kenemans P, Thomas CMG. Heterophilic antibodies in human sera causing falsely increased results in the CA 125 immunofluorametric assay. Clin Chem 1990;36:888-91.
7. Iurpeinen U, Lehtovirta P, Stenman U. CA 125 determined by three methods in samples from patients with human anti-mouse antibodies (HAMA). Clin Chem 1995;41:1667-9.
8. Sosolik RC, Hitchcock CL, Becker WJ. Heterophilic antibodies produce spuriously elevated concentrations of the MB isozyme of creatine kinase in a selected patient population. Am J Clin Pathol 1997;107:506-10.