Safety and effectiveness of continuous aerosolized albuterol in the non-Intensive care setting

Pediatrics

Volumn 134, Issue 4, 2014, Pages e976-e982

  Kenyon, Chén C ^a   Fieldston, Evan S ^a   Luan, Xianqun ^a   Keren, Ron ^a   Zorc, Joseph J ^b  

^a Center for Pediatric Clinical Effectiveness   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Continuous aerosolized albuterol; Hospitalization; Status asthmaticus

Indexed keywords

MAGNESIUM; SALBUTAMOL; TERBUTALINE; BRONCHODILATING AGENT;

ADOLESCENT; ADULT; AGE; ARTICLE; ASSISTED VENTILATION; ASTHMATIC STATE; BREATHING RATE; CHILD; CHILD HOSPITALIZATION; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG INTERMITTENT THERAPY; DRUG SAFETY; FEMALE; GENERAL CONDITION DETERIORATION; HEART ARRHYTHMIA; HEART DEATH; HEART RATE; HOSPITAL PATIENT; HUMAN; HYPOKALEMIA; MAJOR CLINICAL STUDY; MALE; NEBULIZER; OXYGEN SATURATION; PATIENT CARE; PNEUMONIA; PRIORITY JOURNAL; RACE DIFFERENCE; RETROSPECTIVE STUDY; RISK FACTOR; TREATMENT DURATION; TREATMENT OUTCOME; ARRHYTHMIAS, CARDIAC; CHEMICALLY INDUCED; DRUG ADMINISTRATION; HOSPITALIZATION; PRESCHOOL CHILD; STATUS ASTHMATICUS; TRENDS;

ADOLESCENT; ALBUTEROL; ARRHYTHMIAS, CARDIAC; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; HOSPITALIZATION; HUMANS; MALE; NEBULIZERS AND VAPORIZERS; RETROSPECTIVE STUDIES; STATUS ASTHMATICUS;

EID: 84925545848     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2014-0907     Document Type: Article

References (20)

1. Yu H, Wier L. Hospital Stays for Children, 2009: HCUP Statistical Brief #118. Rockville, MD: Agency for Healthcare Research and Quality; 2011. Available at www.hcup-us.ahrq. gov/reports/statbriefs/sb118.jsp. Accessed March 2, 2014
2. Sala KA, Carroll CL, Tang Y-S, Aglio T, Dressler AM, Schramm CM. Factors associated with the development of severe asthma exacerbations in children. J Asthma. 2011;48(6): 558-564. doi:10.3109/02770903.2011.585411
3. Camargo CA Jr, Spooner CH, Rowe BH. Continuous versus intermittent beta-agonists in the treatment of acute asthma. Cochrane Database Syst Rev. 2003; (4):CD001115. doi: 10.1002/14651858.CD001115
4. Papo MC, Frank J, Thompson AE. A prospective, randomized study of continuous versus intermittent nebulized albuterol for severe status asthmaticus in children. Crit Care Med. 1993;21(10):1479-1486
5. Jaimovich DG; American Academy of Pediatrics Committee on Hospital Care and Section on Critical Care. Admission and discharge guidelines for the pediatric patient requiring intermediate care. Pediatrics. 2004;113(5): 1430-1433
6. Streetman DD, Bhatt-Mehta V, Johnson CE. Management of acute, severe asthma in children. Ann Pharmacother. 2002;36(7-8):1249-1260
7. Salo D, Tuel M, Lavery RF, Reischel U, Lebowitz J, Moore T. A randomized, clinical trial comparing the efficacy of continuous nebulized albuterol (15 mg) versus continuous nebulized albuterol (15 mg) plus ipratropium bromide (2 mg) for the treatment of acute asthma. J Emerg Med. 2006;31(4):371-376. doi:10.1016/j.jemermed.2006.05.025
8. Stevens MW, Gorelick MH, Schultz T. Interrater agreement in the clinical evaluation of acute pediatric asthma. JAsthma. 2003;40(3):311-315
9. Feudtner C, Christakis DA, Connell FA. Pediatric deaths attributable to complex chronic conditions: a population-based study of Washington State, 1980-1997. Pediatrics. 2000; 106(1 Pt 2):205-209
10. Bonafide CP, Brady PW, Keren R, Conway PH, Marsolo K, Daymont C. Development of heart and respiratory rate percentile curves for hospitalized children. Pediatrics. 2013;131(4). Available at: www.pediatrics.org/cgi/content/ full/131/4/e1150. doi:10.1542/peds.2012-2443
11. Sheikh S, Khan N, Ryan-Wenger NA, McCoy KS. Demographics, clinical course, and outcomes of children with status asthmaticus treated in a pediatric intensive care unit: 8-year review. J Asthma. 2013;50(4):364-369. doi:10.3109/02770903.2012.757781
12. Alvarez GG, Schulzer M, Jung D, Fitzgerald JM. A systematic review of risk factors associated with near-fatal and fatal asthma. Can Respir J. 2005;12(5):265-270
13. Dhuper S, Maggiore D, Chung V, Shim C. Profile of near-fatal asthma in an inner-city hospital. Chest. 2003;124(5):1880-1884
14. Portnoy J, Nadel G, Amado M, Willsie-Ediger S. Continuous nebulization for status asthmaticus. Ann Allergy. 1992;69(1):71-79
15. Andrews T, McGintee E, Mittal MK, et al Highdose continuous nebulized levalbuterol for pediatric status asthmaticus: a randomized trial. J Pediatr. 2009;155(2):205-210.e1. doi: 10.1016/j.jpeds.2009.01.073
16. Krebs SE, Flood RG, Peter JR, Gerard JM. Evaluation of a high-dose continuous albuterol protocol for treatment of pediatric asthma in the emergency department. Pediatr Emerg Care. 2013;29(2):191-196. doi:10.1097/PEC. 0b013e3182809b48
17. Williams SJ, Winner SJ, Clark TJ. Comparison of inhaled and intravenous terbutaline in acute severe asthma. Thorax. 1981;36(8): 629-631
18. Salmeron S, Brochard L, Mal H, et al. Nebulized versus intravenous albuterol in hypercapnic acute asthma. A multicenter, double-blind, randomized study. Am J Respir Crit Care Med. 1994;149(6):1466-1470. doi:10.1164/ ajrccm.149.6.8004299
19. Schuh S, Johnson D, Stephens D, Callahan S, Canny G. Hospitalization patterns in severe acute asthma in children. Pediatr Pulmonol. 1997;23(3):184-192. doi:10.1002/(SICI) 1099-0496(199703)23:3,184:AID-PPUL3.3.0. CO;2-O
20. Pendergraft TB, Stanford RH, Beasley R, Stempel DA, Roberts C, McLaughlin T. Rates and characteristics of intensive care unit admissions and intubations among asthmarelated hospitalizations. Ann Allergy Asthma Immunol. 2004;93(1):29-35. doi:10.1016/S1081- 1206(10)61444-5