High mTORC1 signaling is maintained, while protein degradation pathways are perturbed in old murine skeletal muscles in the fasted state

International Journal of Biochemistry and Cell Biology

Volumn 78, Issue , 2016, Pages 10-21

  White, Zoe ^a,b   White, Robert B ^a   McMahon, Christopher ^c   Grounds, Miranda D ^a   Shavlakadze, Tea ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c RUAKURA RESEARCH CENTRE   (New Zealand)

Author keywords

Aging; Autophagy; mTORC1; Muscle; p62; Protein degradation

Indexed keywords

GLUCOSE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MUSCLE RING FINGER 1 PROTEIN; PROTEASOME; PROTEIN P62; UBIQUITIN;

ADULT; AGE; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; EPIDIDYMIS FAT; GASTROCNEMIUS MUSCLE; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; MOUSE; MUSCLE MASS; NONHUMAN; PHENOTYPE; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN HOMEOSTASIS; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; QUADRICEPS FEMORIS MUSCLE; SARCOPENIA; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOLEUS MUSCLE; ANIMAL; C57BL MOUSE; CYTOLOGY;

ANIMALS; AUTOPHAGY; FASTING; MALE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84977655555     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2016.06.012     Document Type: Article

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