Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin

Toxicology and Applied Pharmacology

Volumn 306, Issue , 2016, Pages 36-46

  Camerino, Giulia Maria ^a   De Bellis, Michela ^a   Conte, Elena ^a   Liantonio, Antonella ^a   Musaraj, Kejla ^a   Cannone, Maria ^a   Fonzino, Adriano ^a   Giustino, Arcangela ^a   De Luca, Annamaria ^a   Romano, Rossella ^a   Camerino, Claudia ^a   Laghezza, Antonio ^a   Loiodice, Fulvio ^a   Desaphy, Jean Francois ^a   Conte Camerino, Diana ^a   Pierno, Sabata ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Energy metabolism dysfunction; Ion channels; Protein kinase C; Senescence; Skeletal muscle atrophy

Indexed keywords

ATORVASTATIN; FURA 2; MESSENGER RNA; MYOCYTE ENHANCER FACTOR 2; PROTEIN KINASE C; RYANODINE RECEPTOR; CALCIUM; CHLORIDE CHANNEL; CLC-1 CHANNEL; CREATINE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BIOPHYSICS; ENZYME ACTIVITY; EXCITABILITY; HISTOLOGY; MICROELECTRODE; MOLECULAR BIOLOGY; MUSCLE INJURY; MUSCLE METABOLISM; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BLOOD; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; MALE; METABOLISM; MUSCLE ATROPHY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SKELETAL MUSCLE; WISTAR RAT;

AGING; ANIMALS; ATORVASTATIN CALCIUM; CALCIUM; CHLORIDE CHANNELS; CREATINE KINASE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MEF2 TRANSCRIPTION FACTORS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PROTEIN KINASE C; RATS, WISTAR;

EID: 84977650758     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2016.06.032     Document Type: Article

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