Statin or fibrate chronic treatment modifies the proteomic profile of rat skeletal muscle

Biochemical Pharmacology

Volumn 81, Issue 8, 2011, Pages 1054-1064

  Camerino, Giulia Maria ^a   Pellegrino, Maria Antonietta ^b   Brocca, Lorenza ^b   Digennaro, Claudio ^a   Camerino, Diana Conte ^a   Pierno, Sabata ^a   Bottinelli, Roberto ^b  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

Hypolipidemic drugs; Myopathy; Proteomic analysis; Side effects; Skeletal muscle

Indexed keywords

ATORVASTATIN; CREATINE KINASE; FENOFIBRATE; FIBRIC ACID DERIVATIVE; FLUINDOSTATIN; GLYCOLYTIC ENZYME; HEAT SHOCK PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MUSCLE PROTEIN; OXIDOREDUCTASE; PLASMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DOWN REGULATION; ENERGY YIELD; EXTENSOR DIGITORUM LONGUS MUSCLE; IMMUNOBLOTTING; MASS SPECTROMETRY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEOMICS; RAT; SKELETAL MUSCLE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FIBRIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOBLOTTING; ISOELECTRIC FOCUSING; MALE; MUSCLE FIBERS, FAST-TWITCH; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR DISEASES; OXIDATIVE STRESS; PROTEOME; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 79952986828     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.01.022     Document Type: Article

References (63)

1. J.L. Goldstein, and M.S. Brown Regulation of the mevalonate pathway Nature 343 1990 425 430
2. C.P. Cannon Combination therapy in the management of mixed dyslipidaemia J Intern Med 263 2008 353 355
3. S. Bellosta, R. Paoletti, and A. Corsini Safety of statins: focus on clinical pharmacokinetics and drug interactions Circulation 109 23 (Suppl. 1) 2004 III50 III57
4. R.S. Rosenson Statins: can the new generation make an impression? Expert Opin Emerg Drugs 9 2 2004 269 1269
5. K.A. Antons, C.D. Williams, S.K. Baker, and P.S. Phillips Clinical perspectives of statin-induced rhabdomyolysis Am J Med 119 5 2006 400 409 (Pubitemid 44294467)
6. D.J. Graham, J.A. Staffa, D. Shatin, S.E. Andrade, S.D. Schech, and L. La Grenade Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs JAMA 292 21 2004 2585 2590 (Pubitemid 39577514)
7. J.A. Farmer Learning from the cerivastatin experience Lancet 358 9291 2001 1383 1385 (Pubitemid 33055734)
8. D. Gaist, L.A. Rodríguez, C. Huerta, J. Hallas, and S.H. Sindrup Lipid-lowering drugs and risk of myopathy: a population-based follow-up study Epidemiology 12 5 2001 565 569 (Pubitemid 32761999)
9. P.D. Thompson, P. Clarkson, and R.H. Karas Statin-associated myopathy JAMA 289 13 2003 1681 1690 (Pubitemid 37430274)
10. G. Martin, H. Duez, C. Blanquart, V. Berezowski, P. Poulain, and J.C. Fruchart Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I J Clin Invest 107 11 2001 1423 1432 (Pubitemid 32522036)
11. G. Weitz-Schmidt Statins as anti-inflammatory agents Trends Pharmacol Sci 23 10 2002 482 486 (Pubitemid 35279610)
12. M.F. Demierre, P.D. Higgins, S.B. Gruber, E. Hawk, and S.M. Lippman Statins and cancer prevention Nat Rev Cancer 5 12 2005 930 942 (Pubitemid 41766782)
13. M. Evans, and A. Rees The myotoxicity of statins Curr Opin Lipidol 13 4 2002 415 420 (Pubitemid 34831945)
14. C.J. Vaughan, and A.M. Gotto Jr. Update on statins: 2003 Circulation 110 7 2004 886 892 (Pubitemid 39096019)
15. P.D. Cornwell, A.T. De Souza, and R.G. Ulrich Profiling of hepatic gene expression in rats treated with fibric acid analogs Mutat Res 549 1-2 2004 131 145 (Pubitemid 38553980)
16. M.G. Mohaupt, R.H. Karas, E.B. Babiychuk, V. Sanchez-Freire, K. Monastyrskaya, and L. Iyer Association between statin-associated myopathy and skeletal muscle damage CMAJ 181 1-2 2009 E11 18
17. A. Liantonio, V. Giannuzzi, V. Cippone, G.M. Camerino, S. Pierno, and D.C. Camerino Fluvastatin and atorvastatin affect calcium homeostasis of rat skeletal muscle fibers in vivo and in vitro by impairing the sarcoplasmic reticulum/mitochondria Ca2+-release system J Pharmacol Exp Ther 321 2 2007 626 634 (Pubitemid 46624499)
18. S. Pierno, A. De Luca, A. Liantonio, C. Camerino, and D. Conte Camerino Effects of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle Eur J Pharmacol 364 1 1999 43 48 (Pubitemid 29015785)
19. P. Sirvent, J. Mercier, G. Vassort, and A. Lacampagne Simvastatin triggers mitochondria-induced Ca2+ signaling alteration in skeletal muscle Biochem Biophys Res Commun 329 3 2005 1067 1075 (Pubitemid 40341384)
20. S. Pierno, G.M. Camerino, V. Cippone, J.F. Rolland, J.F. Desaphy, and A. De Luca Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression Br J Pharmacol 156 8 2009 1206 1215
21. A. De Luca, D. Tricarico, S. Pierno, and D. Conte Camerino Aging and chloride channel regulation in rat fast-twitch muscle fibres Pflugers Arch 427 1-2 1994 80 85 (Pubitemid 24131557)
22. S.H. Bryant, and D. Conte Camerino Chloride channel regulation in the skeletal muscle of normal and myotonic goats Pflugers Arch 417 6 1991 605 610
23. S. Pierno, A. De Luca, D. Tricarico, A. Roselli, F. Natuzzi, and E. Ferrannini Potential risk of myopathy by HMG-CoA reductase inhibitors: a comparison of pravastatin and simvastatin effects on membrane electrical properties of rat skeletal muscle fibers J Pharmacol Exp Ther 275 3 1995 1490 1496 (Pubitemid 26129941)
24. S. Pierno, M.P. Didonna, V. Cippone, A. De Luca, M. Pisoni, and A. Frigeri Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study Br J Pharmacol 149 7 2006 909 919 (Pubitemid 44851715)
25. S. Pierno, J.F. Desaphy, A. Liantonio, A. De Luca, A. Zarrilli, and L. Mastrofrancesco Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance J Physiol 584 Pt 3 2007 983 995 (Pubitemid 350031936)
26. E.E. Spangenburg, and Booth FW Molecular regulation of individual skeletal muscle fibre types Acta Physiol Scand 178 2003 413 424 (Pubitemid 36960433)
27. C. Gelfi, A. Vigano, M. Ripamonti, A. Pontoglio, S. Begum, and M.A. Pellegrino The human muscle proteome in aging J Proteome Res 5 6 2006 1344 1353 (Pubitemid 43865805)
28. L. Brocca, G. D'Antona, A. Bachi, and M.A. Pellegrino Amino acid supplements improve native antioxidant enzyme expression in the skeletal muscle of diabetic mice Am J Cardiol 101 11A 2008 57E 62E
29. L. Brocca, M.A. Pellegrino, J.F. Desaphy, S. Pierno, D.C. Camerino, and R. Bottinelli Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb-unloaded mice Exp Physiol 95 2 2010 331 350
30. M. Moriggi, M. Vasso, C. Fania, D. Capitanio, G. Bonifacio, and M. Salanova Long term bed rest with and without vibration exercise countermeasures: effects on human muscle protein dysregulation Proteomics 10 21 2010 3756 3774
31. S. Steiner, C.L. Gatlin, J.J. Lennon, A.M. McGrath, A.M. Aponte, and A.J. Makusky Proteomics to display lovastatin-induced protein and pathway regulation in rat liver Electrophoresis 21 11 2000 2129 2137 (Pubitemid 30435813)
32. S. Steiner, C.L. Gatlin, J.J. Lennon, A.M. McGrath, M.D. Seonarain, and A.J. Makusky Cholesterol biosynthesis regulation and protein changes in rat liver following treatment with fluvastatin Toxicol Lett 120 1-3 2001 369 377 (Pubitemid 32375104)
33. A. Kromer, and B. Moosmann Statin-induced liver injury involves cross-talk between cholesterol and selenoprotein biosynthetic pathways Mol Pharmacol 75 6 2009 1421 1429
34. F.R. Westwood, R.C. Scott, A.M. Marsden, A. Bigley, K. Randall, and Rosuvastatin: characterization of induced myopathy in the rat Toxicol Pathol 36 2 2008 345 352
35. A.T. De Souza, P.D. Cornwell, X. Dai, M.J. Caguyong, and R.G. Ulrich Agonists of the peroxisome proliferator-activated receptor alpha induce a fiber-type-selective transcriptional response in rat skeletal muscle Toxicol Sci 92 2 2006 578 586 (Pubitemid 44018973)
36. O'Farrell PH High resolution two-dimensional electrophoresis of proteins J Biol Chem 250 10 1975 4007 4021
37. R.J. Talmadge, and R.R. Roy Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms J Appl Physiol 75 5 1993 2337 2340 (Pubitemid 23352414)
38. M.A. Pellegrino, M. Canepari, R. Rossi, G. D'Antona, C. Reggiani, and Bottinelli R Orthologous myosin isoforms and scaling of shortening velocity with body size in mouse, rat, rabbit and human muscles J Physiol 546 Pt 3 2003 677 689 (Pubitemid 36204505)
39. R. Laaksonen, M. Katajamaa, H. Päivä, M. Sysi-Aho, L. Saarinen, and P. Junni A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle PLoS ONE 1 1 2006 e97
40. J.F. Desaphy, S. Pierno, A. Liantonio, V. Giannuzzi, C. Digennaro, and M.M. Dinardo Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles Pharmacol Res 61 6 2010 553 563
41. P. Nemeth, and D. Pette Succinate dehydrogenase activity in fibres classified by myosin ATPase in three hind limb muscles of rat J Physiol 320 1981 73 80 (Pubitemid 12239788)
42. S. Schiaffino, and C. Reggiani Molecular diversity of myofibrillar proteins: gene regulation and functional significance Physiol Rev 76 2 1996 371 423 (Pubitemid 26163713)
43. M. Flück, and H. Hoppeler Molecular basis of skeletal muscle plasticity - from gene to form and function Rev Physiol Biochem Pharmacol 146 2003 159 216
44. H. Päivä, K.M. Thelen, R. Van Coster, J. Smet, B. De Paepe, and K.M. Mattila High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial Clin Pharmacol Ther 78 1 2005 60 68 (Pubitemid 40956932)
45. K. Nakahara, M. Kuriyama, Y. Sonoda, H. Yoshidome, H. Nakagawa, and J. Fujiyama Myopathy induced by HMG-CoA reductase inhibitors in rabbits: a pathological, electrophysiological, and biochemical study Toxicol Appl Pharmacol 152 1 1998 99 106 (Pubitemid 28498678)
46. C. Vaklavas, Y.S. Chatzizisis, A. Ziakas, C. Zamboulis, and G.D. Giannoglou Molecular basis of statin-associated myopathy Atherosclerosis 202 1 2008 18 28
47. H. Nakagawa, T. Mutoh, T. Kumano, and Kuriyama M HMG-CoA reductase inhibitor-induced L6 myoblast cell death: involvement of the phosphatidylinositol 3-kinase pathway FEBS Lett 438 3 1998 289 292 (Pubitemid 28529291)
48. T. Nishimoto, R. Tozawa, Y. Amano, T. Wada, Y. Imura, and Y. Sugiyama Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes Biochem Pharmacol 66 11 2003 2133 2139 (Pubitemid 37377859)
49. W. Wang, and C.W. Wong Statins enhance peroxisome proliferator-activated receptor gamma coactivator-1 alpha activity to regulate energy metabolism J Mol Med 88 2010 309 317
50. J. Hanai, P. Cao, P. Tanksale, S. Imamura, E. Koshimizu, and J. Zhao The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity J Clin Invest 117 12 2007 3940 3951 (Pubitemid 350224103)
51. S. DiMauro, and C. Lamperti Muscle glycogenoses Muscle Nerve 24 8 2001 984 999 (Pubitemid 32656185)
52. A. Toscano, and O. Musumeci Tarui disease and distal glycogenoses: clinical and genetic update Acta Myol 26 2 2007 105 107 (Pubitemid 351271104)
53. W.H. Schaefer, J.W. Lawrence, A.F. Loughlin, D.A. Stoffregen, L.A. Mixson, and D.C. Dean Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats Toxicol Appl Pharmacol 194 1 2004 10 23 (Pubitemid 38064437)
54. I. Momken, P. Lechene, N. Koulmann, D. Fortin, P. Mateo, and B.T. Doan Impaired voluntary running capacity of creatine kinase-deficient mice J Physiol 565 2005 951 964 (Pubitemid 40903303)
55. E. Cabiscol, and R.L. Levine Carbonic anhydrase III. Oxidative modification in vivo and loss of phosphatase activity during aging J Biol Chem 270 24 1995 14742 14747
56. S.R. Räisänen, P. Lehenkari, M. Tasanen, P. Rahkila, P.L. Härkönen, and H.K. Väänänen Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis FASEB J 13 3 1999 513 522 (Pubitemid 29115569)
57. S. Tartakover-Matalon, N. Cherepnin, M. Kuchuk, L. Drucker, I. Kenis, and A. Fishman Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression Hum Reprod 22 4 2007 1161 1167
58. C. Schmeer, A. Gámez, S. Tausch, O.W. Witte, and S. Isenmann Statins modulate heat shock protein expression and enhance retinal ganglion cell survival after transient retinal ischemia/reperfusion in vivo Invest Ophthalmol Vis Sci 49 11 2008 4971 4981
59. J.S. Moylan, and M.B. Reid Oxidative stress, chronic disease, and muscle wasting Muscle Nerve 35 2007 411 429 (Pubitemid 46542961)
60. S.K. Powers, A.N. Kavazis, and J.M. McClung Oxidative stress and disuse muscle atrophy J Appl Physiol 102 2007 2389 2397 (Pubitemid 47080773)
61. N. Hachiya, T. Komiya, R. Alam, J. Iwahashi, M. Sakaguchi, and T. Omura MSF, a novel cytoplasmic chaperone which functions in precursor targeting to mitochondria EMBO J 13 21 1994 5146 5154 (Pubitemid 24341096)
62. C.E. Ha, J.S. Ha, A.G. Theriault, and N.V. Bhagavan Effects of statins on the secretion of human serum albumin in cultured HepG2 cells J Biomed Sci 16 2009 16 32
63. J. Klawitter, T. Shokati, V. Moll, U. Christians, and J. Klawitter Effects of lovastatin on breast cancer cells: a proteo-metabonomic study Breast Cancer Res 12 2 2010 R16