GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy

Pharmacological Research

Volumn 72, Issue , 2013, Pages 9-24

  Cozzoli, Anna ^a   Capogrosso, Roberta Francesca ^a   Sblendorio, Valeriana Teresa ^a   Dinardo, Maria Maddalena ^a   Jagerschmidt, Catherine ^b   Namour, Florence ^b   Camerino, Giulia Maria ^a   De Luca, Annamaria ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Galapagos SASU   (France)

Author keywords

Biochemical biomarkers; Duchenne muscular dystrophy; Electrophysiology; Exercise performance; Fibrosis; Histopathology; In vivo forelimb force; Isometric and eccentric muscle contraction; Mdx mouse model; Selective androgen receptor modulators; Skeletal muscle

Indexed keywords

CREATINE KINASE; GLPG 0492; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE; NANDROLONE; SELECTIVE ANDROGEN RECEPTOR MODULATOR; TESTOSTERONE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG EFFICACY; DUCHENNE MUSCULAR DYSTROPHY; ELECTROPHYSIOLOGY; EX VIVO STUDY; EXERCISE TEST; EXTENSOR DIGITORUM LONGUS MUSCLE; FATIGUE; IN VIVO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LEG MUSCLE; MALE; MOUSE; MUSCLE FUNCTION; MUSCLE ISOMETRIC CONTRACTION; MUSCLE STRENGTH; MYOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RUNNING; TESTOSTERONE BLOOD LEVEL;

ANDROGENS; ANIMALS; GLUCOCORTICOIDS; HYDANTOINS; MALE; METHYLPREDNISOLONE; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; NANDROLONE; PHYSICAL CONDITIONING, ANIMAL; RECEPTORS, ANDROGEN;

EID: 84876994641     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.03.003     Document Type: Article

References (44)

1. E.P. Hoffman, and D. Dressman Molecular pathophysiology and targeted therapeutics for muscular dystrophy Trends in Pharmacological Sciences 22 2001 465 470
2. M.D. Grounds, H.G. Radley, G.S. Lynch, K. Nagaraju, and A. De Luca Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy Neurobiology of Disease 31 2008 1 19
3. T.A. Rando, M.H. Disatnik, Y. Yu, and A. Franco Muscle cells from mdx mice have an increased susceptibility to oxidative stress Neuromuscular Disorders 8 1 1998 14 21
4. B. Fraysse, A. Liantonio, M. Cetrone, R. Burdi, S. Pierno, and A. Frigeri The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivo Neurobiology of Disease 17 2004 144 154
5. Y.W. Chen, K. Nagaraju, M. Bakay, O. McIntyre, R. Rawat, and R. Shi Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy Neurology 65 2005 826 834
6. J.F. Rolland, A. De Luca, R. Burdi, F. Andreetta, P. Confalonieri, and D. Conte Camerino Overactivity of exercise-sensitive cation channels and their impaired modulation by IGF-1 in mdx native muscle fibers: beneficial effect of pentoxifylline Neurobiology of Disease 24 2006 466 474
7. Y. Lai, G.D. Thomas, Y. Yue, H.T. Yang, D. Li, and C. Long Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy Journal of Clinical Investigation 119 2009 624 635
8. V.M. Shkryl, A.S. Martins, N.D. Ullrich, M.C. Nowycky, E. Niggli, and N. Shirokova Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers Pflügers Archiv 458 5 2009 915 928
9. N.P. Whitehead, E.W. Yeung, S.C. Froehner, and D.G. Allen Skeletal muscle NADPH oxidase is increased and triggers stretch-induced damage in the mdx mouse PLoS ONE 5 12 2010 e15354
10. S.A. Villalta, C. Rinaldi, B. Deng, G. Liu, B. Fedor, and J.G. Tidball Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype Human Molecular Genetics 20 4 2011 790 805
11. C. Pichavant, A. Aartsma-Rus, P.R. Clemens, K.E. Davies, G. Dickson, and S. Takeda Current status of pharmaceutical and genetic therapeutic approaches to treat DMD Molecular Therapy 19 2011 830 840
12. K. Bushby, R. Finkel, D.J. Birnkrant, L.E. Case, P.R. Clemens, and L. Cripe Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management Lancet Neurology 9 2010 77 93
13. S. Bogdanovich, T.O. Krag, E.R. Barton, L.D. Morris, L.A. Whittemore, and R.S. Ahima Functional improvement of dystrophic muscle by myostatin blockade Nature 420 6914 2002 418 421
14. K. Patel, and H. Amthor The function of Myostatin and strategies of Myostatin blockade new hope for therapies aimed at promoting growth of skeletal muscle Neuromuscular Disorders 2 2005 117 126
15. H. Amthor, R. Macharia, R. Navarrete, M. Schuelke, S.C. Brown, and A. Otto Lack of myostatin results in excessive muscle growth but impaired force generation Proceedings of the National Academy of Sciences of the United States of America 104 6 2007 1835 1840
16. S.M. Gehrig, R. Koopman, T. Naim, C. Tjoakarfa, and G.S. Lynch Making fast-twitch dystrophic muscles bigger protects them from contraction injury and attenuates the dystrophic pathology American Journal of Pathology 176 1 2010 29 33
17. K.T. Murphy, J.G. Ryall, S.M. Snell, L. Nair, R. Koopman, and P.A. Krasney Antibody-directed myostatin inhibition improves diaphragm pathology in young but not adult dystrophic mdx mice American Journal of Pathology 176 5 2010 2425 2434
18. M.J. Krahn, and J.E. Anderson Anabolic steroid treatment increases myofiber damage in mdx mouse muscular dystrophy Journal of the Neurological Sciences 125 2 1994 138 146
19. C. Souccar, C. Gonçalo Mdo, S. Buck Hde, M.T. Lima-Landman, and A.J. Lapa Mild dystrophic damage in the androgen-sensitive levator ani muscle of the mdx mouse Neuromuscular Disorders 15 1 2005 48 55
20. G. Fenichel, A. Pestronk, J. Florence, V. Robison, and V. Hemelt A beneficial effect of oxandrolone in the treatment of Duchenne muscular dystrophy: a pilot study Neurology 48 5 1997 1225 1226
21. G.M. Fenichel, R.C. Griggs, J. Kissel, T.I. Kramer, J.R. Mendell, and R.T. Moxley A randomized efficacy and safety trial of oxandrolone in the treatment of Duchenne dystrophy Neurology 56 8 2001 1075 1079
22. P. Balagopal, R. Olney, D. Darmaun, E. Mougey, M. Dokler, and G. Sieck Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy American Journal of Physiology - Endocrinology and Metabolism 290 3 2006 E530 E539
23. S. Bhasin, and R. Jasuja Selective androgen receptor modulators as function promoting therapies Current Opinion in Clinical Nutrition and Metabolic Care 12 3 2009 232 240
24. R. Narayanan, M.L. Mohler, C.E. Bohl, D.D. Miller, and J.T. Dalton Selective androgen receptor modulators in preclinical and clinical development Nuclear Receptor Signaling 6 2008 e010
25. A. De Luca, S. Pierno, A. Liantonio, M. Cetrone, C. Camerino, and B. Fraysse Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 Journal of Pharmacology and Experimental Therapeutics 304 1 2003 453 463
26. A. De Luca, B. Nico, A. Liantonio, M.P. Didonna, B. Fraysse, and S. Pierno A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice American Journal of Pathology 166 2 2005 477 489
27. R. Burdi, J.F. Rolland, B. Fraysse, K. Litvinova, A. Cozzoli, and V. Giannuzzi Multiple pathological events in exercised dystrophic mdx mice are targeted by pentoxifylline: outcome of a large array of in vivo and ex vivo tests Journal of Applied Physiology 106 4 2009 1311 1324
28. S.V. Brooks, and J.A. Faulkner Contractile properties of skeletal muscles from young, adult and aged mice Journal of Physiology 404 1988 71 82
29. A. Cozzoli, B. Nico, V.T. Sblendorio, R.F. Capogrosso, M.M. Dinardo, and V. Longo Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice Pharmacological Research 64 5 2011 482-92.a
30. A. Cozzoli, J.F. Rolland, R.F. Capogrosso, V.T. Sblendorio, V. Longo, and S. Simonetti Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy Neuropathology and Applied Neurobiology 37 3 2011 243-56.b
31. T. Shavlakadze, J. Chai, K. Maley, G. Cozens, G. Grounds, and N. Winn A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo Journal of Cell Science 123 Pt 6 2010 960 971
32. A. Jones, D.J. Hwang, R. Narayanan, D.D. Miller, and J.T. Dalton Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy Endocrinology 151 8 2010 3706 3719
33. W. Gao, P.J. Reiser, C.C. Coss, M.A. Phelps, J.D. Kearbey, and D.D. Miller Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats Endocrinology 146 11 2005 4887 4897
34. J.R. Hoffman, W.J. Kraemer, S. Bhasin, T. Storer, N.A. Ratamess, and G.G. Haff Position stand on androgen and human growth hormone use Journal of Strength and Conditioning Research 23 5 Suppl. 2009 S1 S59
35. A. De Luca Pre-clinical drug tests in the mdx mouse as a model of dystrophinopathies: an overview Acta Myologica 31 1 2012 40 47
36. J.L. Vingren, W.J. Kraemer, N.A. Ratamess, J.M. Anderson, J.S. Volek, and C.M. Maresh Testosterone physiology in resistance exercise and training: the up-stream regulatory elements Sports Medicine 40 12 2010 1037 1053
37. D.W. West, and S.M. Phillips Anabolic processes in human skeletal muscle: restoring the identities of growth hormone and testosterone Physician and Sportsmedicine 38 3 2010 97 104
38. T. Verhovshek, Y. Cai, M.C. Osborne, and D.R. Sengelaub Androgen regulates brain-derived neurotrophic factor in spinal motoneurons and their target musculature Endocrinology 151 1 2010 253 261
39. M.L. Bianchi, D. Biggar, K. Bushby, A.D. Rogol, M.M. Rutter, and B. Tseng Endocrine aspects of Duchenne muscular dystrophy Neuromuscular Disorders 21 4 2011 298 303
40. R. Willmann, S. Possekel, J. Dubach-Powell, T. Meier, and M.A. Ruegg Mammalian animal models for Duchenne muscular dystrophy Neuromuscular Disorders 19 2009 241 249
41. W.V. Bleisch, and A. Harrelson Androgens modulate endplate size and ACh receptor density at synapses in rat levator ani muscle Journal of Neurobiology 20 1989 189 202
42. H.V. Heemers, and D.J. Tindall Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex Endocrine Reviews 28 7 2007 778 808
43. H.J. Ting, S. Yeh, K. Nishimura, and C. Chang Supervillin associates with androgen receptor and modulates its transcriptional activity Proceedings of the National Academy of Sciences of the United States of America 99 2 2002 661 666
44. S.W. Oh, R.K. Pope, K.P. Smith, J.L. Crowley, T. Nebl, and J.B. Lawrence Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton Journal of Cell Science 116 Pt 11 2003 2261 2275