Clinical human hepatocyte transplantation: Current status and challenges

Liver Transplantation

Volumn 21, Issue , 2015, Pages S39-S44

  Dhawan, Anil ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; CELL THERAPY AGENT; HEPATOCYTE MICROBEAD; UNCLASSIFIED DRUG;

ACUTE LIVER FAILURE; ARTICLE; CELL ISOLATION; COCULTURE; END STAGE LIVER DISEASE; ENGRAFTMENT; HEPATOCYTE TRANSPLANTATION; HUMAN; LIVER CELL; MESENCHYMAL STEM CELL; METABOLIC DISORDER; MICROENCAPSULATION; PRIORITY JOURNAL; UREA CYCLE DISORDER;

EID: 84977635245     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.24226     Document Type: Article

References (60)

1. Fox IJ, Roy-Chowdhury J. Hepatocyte transplantation. J Hepatol 2004;40:878-886.
2. Dhawan A, Mitry RR, Hughes RD. Hepatocyte transplantation for liver-based metabolic disorders. J Inherit Metab Dis 2006;29:431-435.
3. Fisher RA, Strom SC. Human hepatocyte transplantation: worldwide results. Transplantation 2006;82:441-449.
4. Dhawan A, Puppi J, Hughes RD, Mitry RR. Human hepatocyte transplantation: current experience and future challenges. Nature Rev Gastroenterol Hepatol 2010;7:288-298.
5. Dhawan A, Mitry RR, Hughes RD, Lehec S, Terry C, Bansal S, et al. Hepatocyte transplantation for inherited factor VII deficiency. Transplantation 2004;78:1812-1814.
6. Puppi J, Tan N, Mitry RR, Hughes RD, Lehec S, Mieli-Vergani G, et al. Hepatocyte transplantation followed by auxiliary liver transplantation--a novel treatment for ornithine transcarbamylase deficiency. Am J Transplant 2008;8:452-457.
7. Strom SC, Chowdhury JR, Fox IJ. Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis 1999;19:39-48.
8. Hughes RD, Mitry RR, Dhawan A. Hepatocyte transplantation for metabolic liver disease: UK experience. J R Soc Med 2005;98:341-345.
9. Puppi J, Strom SC, Hughes RD, Bansal S, Castell JV, Dagher I, et al. Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London. Cell Transplant 2012;21:1-10.
10. Hughes RD, Mitry RR, Dhawan A, Lehec SC, Girlanda R, Rela M, et al. Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation. Liver Transpl 2006;12:713-717.
11. Mitry RR, Hughes RD, Aw MM, Terry C, Mieli-Vergani G, Girlanda R, et al. Human hepatocyte isolation and relationship of cell viability to early graft function. Cell Transplant 2003;12:69-74.
12. Mitry RR, Dhawan A, Hughes RD, Bansal S, Lehec S, Terry C, et al. One liver, three recipients: segment IV from split-liver procedures as a source of hepatocytes for cell transplantation. Transplantation 2004;77:1614-1616.
13. Lehec SC, Hughes RD, Mitry RR, Graver MA, Verma A, Wade JJ, Dhawan A. Experience of microbiological screening of human hepatocytes for clinical transplantation. Cell Transplant 2009;18:941-947.
14. Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010;51:679-689.
15. Sagias FG, Mitry RR, Hughes RD, Lehec SC, Patel AG, Rela M, et al. N-acetylcysteine improves the viability of human hepatocytes isolated from severely steatotic donor liver tissue. Cell Transplant 2010;19:1487-1492.
16. Bhogal RH, Hodson J, Bartlett DC, Weston CJ, Curbishley SM, Haughton E, et al. Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience. PLoS One 2011;6:e18222.
17. Stéphenne X, Najimi M, Smets F, Reding R, de Ville de Goyet J, Sokal EM. Cryopreserved liver cell transplantation controls ornithine transcarbamylase deficient patient while awaiting liver transplantation. Am J Transplant 2005;5:2058-2061.
18. Terry C, Dhawan A, Mitry RR, Hughes RD. Cryopreservation of isolated human hepatocytes for transplantation: State of the art. Cryobiology 2006;53:149-159.
19. Terry C, Mitry RR, Lehec SC, Muiesan P, Rela M, Heaton ND, et al. The effects of cryopreservation on human hepatocytes obtained from different sources of liver tissue. Cell Transplant 2005;14:585-594.
20. Terry C, Hughes RD, Mitry RR, Lehec SC, Dhawan A. Cryopreservation-induced nonattachment of human hepatocytes: role of adhesion molecules. Cell Transplant 2007;16:639-647.
21. Terry C, Dhawan A, Mitry RR, Lehec SC, Hughes RD. Optimization of the cryopreservation and thawing protocol for human hepatocytes for use in cell transplantation. Liver Transpl 2010;16:229-237.
22. Pless G, Sauer IM, Rauen U. Improvement of the cold storage of isolated human hepatocytes. Cell Transplant 2011;21:23-37.
23. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998;338:1422-1426.
24. Horslen SP, McCowan TC, Goertzen TC, Warkentin PI, Cai HB, Strom SC, Fox IJ. Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics 2003;111(pt 1):1262-1267.
25. Gupta S, Rajvanshi P, Sokhi R, Slehria S, Yam A, Kerr A, Novikoff PM. Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology 1999;29:509-519.
26. Joseph B, Malhi H, Bhargava KK, Palestro CJ, McCuskey RS, Gupta S. Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver. Gastroenterology 2002;123:1677-1685.
27. Johansson H, Lukinius A, Moberg L, Lundgren T, Berne C, Foss A, et al. Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes 2005;54:1755-1762.
28. Stéphenne X, Vosters O, Najimi M, Beuneu C, Dung KN, Wijns W, et al. Tissue factor-dependent procoagulant activity of isolated human hepatocytes: relevance to liver cell transplantation. Liver Transpl 2007;13:599-606.
29. Gustafson EK, Elgue G, Hughes RD, Mitry RR, Sanchez J, Haglund U, et al. The instant blood-mediated inflammatory reaction characterized in hepatocyte transplantation. Transplantation 2011;91:632-638.
30. Allen KJ, Mifsud NA, Williamson R, Bertolino P, Hardikar W. Cell-mediated rejection results in allograft loss after liver cell transplantation. Liver Transpl 2008;14:688-694.
31. Han B, Lu Y, Meng B, Qu B. Cellular loss after allogenic hepatocyte transplantation. Transplantation 2009;87:1-5.
32. Najimi M, Smets F, Sokal E. Hepatocyte apoptosis. Methods Mol Biol 2009;481:59-74.
33. Wang LJ, Chen YM, George D, Smets F, Sokal EM, Bremer EG, Soriano HE. Engraftment assessment in human and mouse liver tissue after sex-mismatched liver cell transplantation by real-time quantitative PCR for Y chromosome sequences. Liver Transpl 2002;8:822-828.
34. Mas VR, Maluf DG, Thompson M, Ferreira-Gonzalez A, Fisher RA. Engraftment measurement in human liver tissue after liver cell transplantation by short tandem repeats analysis. Cell Transplant 2004;13:231-236.
35. Stéphenne X, Najimi M, Sibille C, Nassogne MC, Smets F, Sokal EM. Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency. Gastroenterology 2006;30:1317-1323.
36. Quaglia A, Lehec SC, Hughes RD, Mitry RR, Knisely AS, Devereaux S, et al. Liver after hepatocyte transplantation for liver-based metabolic disorders in children. Cell Transplant 2008;17:1403-1414.
37. Bohnen NI, Charron M, Reyes J, Rubinstein W, Strom SC, Swanson D, Towbin R. Use of indium-111-labeled hepatocytes to determine the biodistribution of transplanted hepatocytes through portal vein infusion. Clin Nucl Med 2000;25:447-450.
38. Puppi J, Mitry RR, Modo M, Dhawan A, Raja K, Hughes RD. Use of a clinically approved iron oxide MRI contrast agent to label human hepatocytes. Cell Transplant 2010;20:963-975.
39. Kammer NN, Billecke N, Morgul MH, Adonopoulou MK, Mogl M, Huang MD, et al. Labeling of primary human hepatocytes with micron-sized iron oxide particles in suspension culture suitable for large-scale preparation. Artif Organs 2011;35:E91-E100.
40. Leconte I, Pallu S, Abarca-Quinones J, Michoux N, Peeters F, Radermacher K, et al. MRI of iron-oxide labelled transplanted hepatocytes in mice: effect of treatment with cyclophosphamide. J Magn Reson Imaging 2010;32:367-375.
41. Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, et al. Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside? Gut 2009;58:594-603.
42. Fitzpatrick E, Mitry RR, Dhawan A. Human hepatocyte transplantation: state of the art. J Intern Med 2009;266:339-357.
43. Najimi M, Khuu DN, Lysy PA, Jazouli N, Abarca J, Sempoux C, Sokal EM. Adult-derived human liver mesenchymal-like cells as a potential progenitor reservoir of hepatocytes? Cell Transplant 2007;16:717-728.
44. Stutchfield BM, Forbes SJ, Wigmore SJ. Prospects for stem cell transplantation in the treatment of hepatic disease. Liver Transpl 2010;16:827-836.
45. Zhao T, Zhang ZN, Rong Z, Xu Y. Immunogenicity of induced pluripotent stem cells. Nature 2011;474:212-215.
46. Bonavita AG, Quaresma K, Cotta-de-Almeida V, Pinto MA, Saraiva RM, Alves LA. Hepatocyte xenotransplantation for treating liver disease. Xenotransplantation 2010;17:181-187.
47. van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW, Yarmush ML. Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology 2008;47:1634-1643.
48. Yan Y, Xu W, Qian H, Si Y, Zhu W, Cao H, et al. Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int 2009;29:356-365.
49. Wu Y, Hughes RD, Fitzpatrick E, Lehec S, Mitry RR, Dhawan A. Maintenance of hepatic function in long-term in vitro co-culture with mesenchymal stem cells. Liver Transpl 2011;17:S196.
50. Dagher I, Boudechiche L, Branger J, Coulomb-Lhermine A, Parouchev A, Sentilhes L, et al. Efficient hepatocyte engraftment in a nonhuman primate model after partial portal vein embolization. Transplantation 2006;82:1067-1073.
51. Dagher I, Nguyen TH, Groyer-Picard MT, Lainas P, Mainot S, Guettier C, et al. Efficient hepatocyte engraftment and long-term transgene expression after reversible portal embolization in nonhuman primates. Hepatology 2009;49:950-959.
52. Koenig S, Krause P, Schmidt TK, Rave-Fraenk M, Rothe H, Hermann RM, et al. Irradiation as preparative regimen for hepatocyte transplantation causes prolonged cell cycle block. Int J Radiat Biol 2008;84:285-298.
53. Malhi H, Joseph B, Schilsky ML, Gupta S. Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson’s disease. Regen Med 2008;3:165-173.
54. Yamanouchi K, Zhou H, Roy-Chowdhury N, Macaluso F, Liu L, Yamamoto T, et al. Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation. Hepatology 2009;49:258-267.
55. Koenig S, Yuan Q, Krause P, Christiansen H, Rave-Fraenk M, Kafert-Kasting S, et al. Regional transient portal ischemia and irradiation as preparative regimen for hepatocyte transplantation. Cell Transplant 2011;20:303-311.
56. Habibullah CM, Syed IH, Qamar A, Taher-Uz Z. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994;58:951-952.
57. Mei J, Sgroi A, Mai G, Baertschiger R, Gonelle-Gispert C, Serre-Beinier V, et al. Improved survival of fulminant liver failure by transplantation of microencapsulated cryopreserved porcine hepatocytes in mice. Cell Transplant 2009;18:101-110.
58. Sgroi A, Mai G, Morel P, Baertschiger RM, Gonelle-Gispert C, Serre-Beinier V, Buhler LH. Transplantation of encapsulated hepatocytes during acute liver failure improves survival without stimulating native liver regeneration. Cell Transplant 2011;20:1791-1803.
59. Massie I, Selden C, Hodgson H, Fuller B. Cryopreservation of encapsulated liver spheroids for a bioartificial liver: reducing latent cryoinjury using an ice nucleating agent. Tissue Eng Part C Methods 2011;17:765-774.
60. Philippeos C, Dhawan A, Hughes RD, Fitzpatrick E, Lehec SC, Heaton N, Mitry RR. Effects of ascitic fluid on alginate-encapsulated human hepatocytes in vitro. Hepatology 2010; 52(suppl): 1106A.