Sulforaphane suppresses hepatitis C virus replication by up-regulating heme oxygenase-1 expression through PI3K/Nrf2 pathway

PLoS ONE

Volumn 11, Issue 3, 2016, Pages

  Yu, Jung Sheng ^a,b   Chen, Wei Chun ^c   Tseng, Chin Kai ^d   Lin, Chun Kuang ^e   Hsu, Yao Chin ^a   Chen, Yen Hsu ^f,g,h   Lee, Jin Ching ^g  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^g KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^h NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; ALPHA17 INTERFERON; ALPHA2 INTERFERON; BENZYL ISOTHIOCYANATE; BUTYL ISOTHIOCYANATE; DACLATASVIR; HEME OXYGENASE 1; INTERFERON; NONSTRUCTURAL PROTEIN 3; PHENETHYL ISOTHIOCYANATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTOPORPHYRIN TIN; RECOMBINANT ALPHA2A INTERFERON; SHORT HAIRPIN RNA; SOFOSBUVIR; SULFORAPHANE; TELAPREVIR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; BILIRUBIN; BILIVERDIN; ISOTHIOCYANIC ACID DERIVATIVE; NS3 PROTEIN, HEPATITIS C VIRUS; SULFORAFAN; VIRAL PROTEIN; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IC50; NONHUMAN; PROTEIN EXPRESSION; REPLICON CELL; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS REPLICATION; BIOLOGICAL MODEL; BIOSYNTHESIS; DRUG EFFECTS; HEPACIVIRUS; METABOLISM; PHYSIOLOGY; REPLICON; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANTIVIRAL AGENTS; BILIRUBIN; BILIVERDINE; CELL LINE, TUMOR; DRUG SYNERGISM; HEME OXYGENASE-1; HEPACIVIRUS; HUMANS; INTERFERONS; ISOTHIOCYANATES; MODELS, BIOLOGICAL; NF-E2-RELATED FACTOR 2; PHOSPHATIDYLINOSITOL 3-KINASES; REPLICON; RNA, VIRAL; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84977597202     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0152236     Document Type: Article

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