Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta

Histology and Histopathology

Volumn 31, Issue 9, 2016, Pages 1037-1047

  Soygur, Bikem ^a   Sati, Leyla ^a   Demir, Ramazan ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

Author keywords

Gestational diabetes; Human placenta; MFSD2; SLC1A5; Syncytin

Indexed keywords

AMINO ACID TRANSPORTER; MINOR HISTOCOMPATIBILITY ANTIGEN; PLACENTA PROTEIN; SLC1A5 PROTEIN, HUMAN; SYNCYTIN; SYNCYTIN 2 PROTEIN, HUMAN; VIRUS ENVELOPE PROTEIN;

ADULT; BIOSYNTHESIS; ENDOGENOUS RETROVIRUS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PLACENTA; PREGNANCY; PREGNANCY DIABETES MELLITUS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; AMINO ACID TRANSPORT SYSTEM ASC; BLOTTING, WESTERN; ENDOGENOUS RETROVIRUSES; FEMALE; GENE PRODUCTS, ENV; HUMANS; IMMUNOHISTOCHEMISTRY; MINOR HISTOCOMPATIBILITY ANTIGENS; PLACENTA; PREGNANCY; PREGNANCY IN DIABETICS; PREGNANCY PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84977592315     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: 10.14670/HH-11-735     Document Type: Article

References (52)

1. Benirschke K., Kaufmann P. and Baergen R. (2006). Pathology of the human placenta, Fifth ed. Springer. New York.
2. Blaise S., de Parseval N., Benit L. and Heidmann T. (2003). Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc. Natl. Acad. Sci. USA 100, 13013-13018
3. Blond J.L., Lavillette D., Cheynet V., Bouton O., Oriol G., Chapel-Fernandes S., Mandrand B., Mallet F. and Cosset F.L. (2000). An envelope glycoprotein of the human endogenous retrovirus herv-w is expressed in the human placenta and fuses cells expressing the type d mammalian retrovirus receptor. J. Virol. 74, 3321-3329
4. Chen C.P., Wang K.G., Chen C.Y., Yu C., Chuang H.C. and Chen H. (2006). Altered placental syncytin and its receptor asct2 expression in placental development and pre-eclampsia. BJOG 113, 152-158
5. Chen C.P., Chen L.F., Yang S.R., Chen C.Y., Ko C.C., Chang G.D. and Chen H. (2008). Functional characterization of the human placental fusogenic membrane protein syncytin 2. Biol. Reprod. 79, 815-823
6. Cheng X., Chapple S.J., Patel B., Puszyk W., Sugden D., Yin X., Mayr M., Siow R.C. and Mann G.E. (2013). Gestational diabetes mellitus impairs nrf2-mediated adaptive antioxidant defenses and redox signaling in fetal endothelial cells in utero. Diabetes 62, 4088-4097
7. Daskalakis G., Marinopoulos S., Krielesi V., Papapanagiotou A., Papantoniou N., Mesogitis S. and Antsaklis A. (2008). Placental pathology in women with gestational diabetes. Acta. Obstet. Gynecol. Scand. 87, 403-407.
8. de Parseval N. and Heidmann T. (2005). Human endogenous retroviruses: From infectious elements to human genes. Cytogenet. Genome. Res. 110, 318-332
9. Demir R. (1979). Scanning electron-microscopic observations on the surfaces of chorionic villi of young and mature placentas. Acta. Anat. (Basel) 105, 226-232
10. Demir R. (1980). Ultrastructure of the epithelium of the chorionic villi of the human placenta. Acta. Anat. (Basel) 106, 18-29
11. El Hajj N., Pliushch G., Schneider E., Dittrich M., Muller T., Korenkov M., Aretz M., Zechner U., Lehnen H. and Haaf T. (2013). Metabolic programming of mest DNA methylation by intrauterine exposure to gestational diabetes mellitus. Diabetes 62, 1320-1328
12. Esnault C., Priet S., Ribet D., Vernochet C., Bruls T., Lavialle C., Weissenbach J. and Heidmann T. (2008). A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2. Proc. Natl. Acad. Sci. USA 105, 17532-17537
13. Evers I.M., Nikkels P.G., Sikkema J.M. and Visser G.H. (2003). Placental pathology in women with type 1 diabetes and in a control group with normal and large-for-gestational-age infants. Placenta 24, 819-825
14. Fuke C., Shimabukuro M., Petronis A., Sugimoto J., Oda T., Miura K., Miyazaki T., Ogura C., Okazaki Y. and Jinno Y. (2004). Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: An hplc-based study. Ann. Hum. Genet. 68, 196-204
15. Gabbay-Benziv R. and Baschat A.A. (2015). Gestational diabetes as one of the "great obstetrical syndromes" -the maternal, placental, and fetal dialog. Best. Pract. Res. Clin. Obstet. Gynaecol. 29, 150-155
16. Griffiths D.J. (2001). Endogenous retroviruses in the human genome sequence. Genome. Biol. 2, REVIEWS1017
17. Harris J.R. (1998). Placental endogenous retrovirus (erv): Structural, functional, and evolutionary significance. Bioessays 20, 307-316
18. Hayward M.D., Potgens A.J., Drewlo S., Kaufmann P. and Rasko J.E. (2007). Distribution of human endogenous retrovirus type w receptor in normal human villous placenta. Pathology 39, 406-412
19. Holder B.S., Tower C.L., Abrahams V.M. and Aplin J.D. (2012). Syncytin 1 in the human placenta. Placenta 33, 460-466
20. Huang Q., Li J., Wang F., Oliver M.T., Tipton T., Gao Y. and Jiang S.W. (2013). Syncytin-1 modulates placental trophoblast cell proliferation by promoting g1/s transition. Cell Signal. 25, 1027-1035
21. Jaenisch R. and Bird A. (2003). Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat. Genet. 33 Suppl, 245-254
22. Jensen E.C. (2013). Quantitative analysis of histological staining and fluorescence using image. J. Anat. Rec. (Hoboken) 296, 378-381
23. Kudaka W., Oda T., Jinno Y., Yoshimi N. and Aoki Y. (2008). Cellular localization of placenta-specific human endogenous retrovirus (herv) transcripts and their possible implication in pregnancy-induced hypertension. Placenta 29, 282-289
24. Lager S. and Powell T.L. (2012). Regulation of nutrient transport across the placenta. J. Pregnancy 2012, 179827
25. Lee X., Keith J.C. Jr, Stumm N., Moutsatsos I., McCoy J.M., Crum C.P., Genest D., Chin D., Ehrenfels C., Pijnenborg R., van Assche F.A. and Mi S. (2001). Downregulation of placental syncytin expression and abnormal protein localization in pre-eclampsia. Placenta 22, 808-812
26. Lokossou A.G., Toudic C. and Barbeau B. (2014). Implication of human endogenous retrovirus envelope proteins in placental functions. Viruses 6, 4609-4627
27. Malassine A., Blaise S., Handschuh K., Lalucque H., Dupressoir A., Evain-Brion D. and Heidmann T. (2007). Expression of the fusogenic herv-frd env glycoprotein (syncytin 2) in human placenta is restricted to villous cytotrophoblastic cells. Placenta 28, 185-191
28. Malassine A., Handschuh K., Tsatsaris V., Gerbaud P., Cheynet V., Oriol G., Mallet F. and Evain-Brion D. (2005). Expression of herv-w env glycoprotein (syncytin) in the extravillous trophoblast of first trimester human placenta. Placenta 26, 556-562
29. Malassine A., Frendo J.L., Blaise S., Handschuh K., Gerbaud P., Tsatsaris V., Heidmann T. and Evain-Brion D. (2008). Human endogenous retrovirus-frd envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta. Retrovirology 5, 6
30. Metzger B.E., Gabbe S.G., Persson B., Buchanan T.A., Catalano P.A., Damm P., Dyer A.R., Leiva A., Hod M., Kitzmiler J.L., Lowe L.P., McIntyre H.D., Oats J.J., Omori Y. and Schmidt M.I. (2010). International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 33, 676-682
31. Mi S., Lee X., Li X., Veldman G.M., Finnerty H., Racie L., LaVallie E., Tang X.Y., Edouard P., Howes S., Keith J.C. Jr and McCoy J.M. (2000). Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403, 785-789
32. Mincheva-Nilsson L. and Baranov V. (2014). Placenta-derived exosomes and syncytiotrophoblast microparticles and their role in human reproduction: Immune modulation for pregnancy success. Am. J. Reprod. Immunol. 72, 440-457
33. Mondestin M.A., Ananth C.V., Smulian J.C. and Vintzileos A.M. (2002). Birth weight and fetal death in the united states: The effect of maternal diabetes during pregnancy. Am. J. Obstet. Gynecol. 187, 922-926
34. Muir A., Lever A.M. and Moffett A. (2006). Human endogenous retrovirus-w envelope (syncytin) is expressed in both villous and extravillous trophoblast populations. J. Gen. Virol. 87, 2067-2071
35. Nelissen E.C., van Montfoort A.P., Dumoulin J.C. and Evers J.L. (2011). Epigenetics and the placenta. Hum. Reprod. Update 17, 397-417
36. O'Sullivan J.B.H.M. and Mills JL. (1985). Maternal diabetes in pregnancy. In: Diabetes in America. US Department of Health and Human Services, NIH publication no.85-1468, pp 1-17
37. Rawn S.M. and Cross J.C. (2008). The evolution, regulation, and function of placenta-specific genes. Annu. Rev. Cell Dev. Biol. 24, 159-181
38. Roberson C.D., Atay S., Gercel-Taylor C. and Taylor D.D. (2010). Tumor-derived exosomes as mediators of disease and potential diagnostic biomarkers. Cancer Biomark. 8, 281-291
39. Rote N.S., Chakrabarti S. and Stetzer B.P. (2004). The role of human endogenous retroviruses in trophoblast differentiation and placental development. Placenta 25, 673-683
40. Ruchat S.M., Houde A.A., Voisin G., St-Pierre J., Perron P., Baillargeon J.P., Gaudet D., Hivert M.F., Brisson D. and Bouchard L. (2013). Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases. Epigenetics 8, 935-943
41. Ruebner M., Strissel P.L., Langbein M., Fahlbusch F., Wachter D.L., Faschingbauer F., Beckmann M.W. and Strick R. (2010). Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of herv envelope genes. J. Mol. Med. (Berl) 88, 1143-1156
42. Salomon C., Sobrevia L., Ashman K., Illanes S.E., Mitchell M.D. and Rice G.E. (2014). The role of placental exosomes in gestational diabetes mellitus. In: Gestational diabetes-causes, diagnosis and treatment, Sobrevia L. (ed). InTech.
43. Sati L., Soygur B. and Celik-Ozenci C. (2016). Expression of mammalian target of rapamycin and downstream targets in normal and gestational diabetic human term placenta. Reprod. Sci. 23, 324-332
44. Smallwood A., Papageorghiou A., Nicolaides K., Alley M.K., Jim A., Nargund G., Ojha K., Campbell S. and Banerjee S. (2003). Temporal regulation of the expression of syncytin (herv-w), maternally imprinted peg10, and sgce in human placenta. Biol. Reprod. 69, 286-293
45. Smit A.F. (1999). Interspersed repeats and other mementos of transposable elements in mammalian genomes. Curr. Opin. Genet. Dev. 9, 657-663
46. Smith C.H., Nelson D.M., King B.F., Donohue T.M., Ruzycki S. and Kelley L.K. (1977). Characterization of a microvillous membrane preparation from human placental syncytiotrophoblast: A morphologic, biochemical, and physiologic, study. Am. J. Obstet. Gynecol. 128, 190-196
47. Teasdale F. and Jean-Jacques G. (1986). Morphometry of the microvillous membrane of the human placenta in maternal diabetes mellitus. Placenta 7, 81-88
48. Toufaily C., Vargas A., Lemire M., Lafond J., Rassart E. and Barbeau B. (2013). Mfsd2a, the syncytin-2 receptor, is important for trophoblast fusion. Placenta 34, 85-88
49. Vargas A., Toufaily C., LeBellego F., Rassart E., Lafond J. and Barbeau B. (2011). Reduced expression of both syncytin 1 and syncytin 2 correlates with severity of preeclampsia. Reprod. Sci. 18, 1085-1091
50. Vargas A., Zhou S., Ethier-Chiasson M., Flipo D., Lafond J., Gilbert C. and Barbeau B. (2014). Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia. FASEB J. 28, 3703-3719
51. Villesen P., Aagaard L., Wiuf C. and Pedersen F.S. (2004). Identification of endogenous retroviral reading frames in the human genome. Retrovirology 1, 32
52. West N.A., Kechris K. and Dabelea D. (2013). Exposure to maternal diabetes in utero and DNA methylation patterns in the offspring. Immunometabolism 1, 1-9.