Human endogenous retrovirus-W envelope (syncytin) is expressed in both villous and extravillous trophoblast populations

Journal of General Virology

Volumn 87, Issue 7, 2006, Pages 2067-2071

  Muir, A ^a,c   Lever, A M L ^b   Moffett, A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c PALMERSTON NORTH HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

SYNCYTIN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ARTICLE; BLOOD SAMPLING; CANCER CELL CULTURE; CELL POPULATION; CELL TYPE; CELLULAR DISTRIBUTION; CHORIOCARCINOMA; CONTROLLED STUDY; FIRST TRIMESTER PREGNANCY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TROPHOBLAST;

CELL LINE, TUMOR; CHORIOCARCINOMA; CHORIONIC VILLI; ENDOGENOUS RETROVIRUSES; FEMALE; GENE EXPRESSION; GENE PRODUCTS, ENV; HUMANS; IMMUNOHISTOCHEMISTRY; PREGNANCY; PREGNANCY PROTEINS; PREGNANCY, TUBAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TROPHOBLASTS; UTERINE NEOPLASMS;

HUMAN ENDOGENOUS RETROVIRUS W; HUMAN ENDOGENOUS RETROVIRUSES;

EID: 33745619527     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.81412-0     Document Type: Article

References (30)

1. Al-Lamki, R. S., Skepper, J. N. & Burton, G. J. (1999). Are human placental bed giant cells merely aggregates of small mononuclear trophoblast cells? An ultrastructural and immunocytochemical study. Hum Reprod 14, 496-504.
2. Bénit, L., Dessen, P. & Heidmann, T. (2001). Identification, phylogeny, and evolution of retroviral elements based on their envelope genes. J Virol 75, 11709-11719.
3. Blaise, S., de Parseval, N., Bénit, L. & Heidmann, T. (2003). Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc Natl Acad Sci U S A 100, 13013-13018.
4. Blond, J.-L., Besème, F., Duret, L., Bouton, O., Bedin, F., Perron, H., Mandrand, B. & Mallet, F. (1999). Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family. J Virol 73, 1175-1185.
5. Blond, J.-L., LaVillette, D., Cheynet, V., Bouton, O., Oriol, G., Chapel-Fernandes, S., Mandrand, B., Mallet, F. & Cosset, F.-L. (2000). An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. J Virol 74, 3321-3329.
6. Burrows, T. D., King, A. & Loke, Y. W. (1993). Expression of integrins by human trophoblast and differential adhesion to laminin or fibronectin. Hum Reprod 8, 475-484.
7. Chumbley, G., Hawley, S., Carter, N. P. & Loke, Y. W. (1991). Human extravillous trophoblast MHC class I expression is resistant to regulation by interferon-α. J Reprod Immunol 20, 289-296.
8. Chumbley, G., King, A., Gardner, L., Howlett, S., Holmes, N. & Loke, Y. W. (1994). Generation of an antibody to HLA-G in transgenic mice and demonstration of the tissue reactivity of this antibody. J Reprod Immunol 27, 173-186.
9. Cianciolo, G., Copeland, T. D., Oroszlan, S. & Snyderman, R. (1985). Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins. Science 230, 453-455.
10. de Parseval, N., Lazar, V., Casella, J.-F., Benit, L. & Heidmann, T. (2003). Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins. J Virol 77, 10414-10422.
11. Frendo, J.-L., Olivier, D., Cheynet, V., Blond, J.-L., Bouton, O., Vidaud, M., Rabreau, M., Evain-Brion, D. & Mallet, F. (2003). Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Mol Cell Biol 23, 3566-3574.
12. Harris, D. T., Cianciolo, G. J., Snyderman, R., Argov, S. & Koren, H. S. (1987). Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E. J Immunol 138, 889-894.
13. International Human Genome Sequencing Consortium (2001). Initial sequencing and analysis of the human genome. Nature 409, 860-921.
14. Knerr, I., Beinder, E. & Rascher, W. (2002). Syncytin, a novel human endogenous retroviral gene in human placenta: evidence for its dysregulation in preeclampsia and HELLP syndrome. Am J Obstet Gynecol 186, 210-213.
15. Lee, X., Keith, J. C., Jr, Stumm, N. & 9 other authors (2001). Down-regulation of placental syncytin expression and abnormal protein localization in pre-eclampsia. Placenta 22, 808-812.
16. Loke, Y. W. & Burland, K. (1988). Human trophoblast cells cultured in modified medium and supported by extracellular matrix. Placenta 9, 173-182.
17. Loke, Y. W. & King, A. (1995). Human Implantation: Cell Biology and Immunology. Cambridge: Cambridge University Press.
18. Loke, Y. W., Hsi, B.-L., Bulmer, J., Grivaux, C., Hawley, S., Gardner, L., King, A. & Carter, N. P. (1992). Evaluation of a monoclonal antibody, BC-1, which identifies an antigen expressed on the surface membrane of human extravillous trophoblast. Am J Reprod Immunol 27, 77-81.
19. Loke, Y. W., King, A., Burrows, T., Gardner, L., Bowen, M., Hiby, S., Howlett, S., Holmes, N. & Jacobs, D. (1997). Evaluation of trophoblast HLA-G antigen with a specific monoclonal antibody. Tissue Antigens 50, 135-146.
20. Malassiné, A., Handschuh, K., Tsatsaris, V., Gerbaud, P., Cheynet, V., Oriol, G., Mallet, F. & Evain-Brion, D. (2005). Expression of HERV-W Env glycoprotein (syncytin) in the extravillous trophoblast of first trimester human placenta. Placenta 26, 556-562.
21. Mi, S., Lee, X., Li, X.-P. & 9 other authors (2000). Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403, 785-789.
22. Moffett-King, A. (2002). Natural killer cells and pregnancy. Nat Rev Immunol 2, 656-663.
23. Muir, A., Lever, A. & Moffett, A. (2004). Expression and functions of human endogenous retroviruses in the placenta: an update. Placenta 25 (Suppl. A), S16-S25.
24. Nakagawa, K. & Harrison, L. C. (1996). The potential roles of endogenous retroviruses in autoimmunity. Immunol Rev 152, 193-236.
25. Okahara, G., Matsubara, S., Oda, T., Sugimoto, J., Jinno, Y. & Kanaya, F. (2004). Expression analyses of human endogenous retroviruses (HERVs): tissue-specific and developmental stage-dependent expression of HERVs. Genomics 84, 982-990.
26. Pötgens, A. J. G., Drewlo, S., Kokozidou, M. & Kaufmann, P. (2004). Syncytin: the major regulator of trophoblast fusion? Recent developments and hypotheses on its action. Hum Reprod Update 10, 487-496.
27. Smallwood, A., Papageorghiou, A., Nicolaides, K., Alley, M. K. R., Jim, A., Nargund, G., Ojha, K., Campbell, S. & Banerjee, S. (2003). Temporal regulation of the expression of syncytin (HERV-M, maternally imprinted PEG10, and SGCE in human placenta. Biol Reprod 69, 286-293.
28. Stoye, J. P. & Coffin, J. M. (2000). A provirus put to work. Nature 403, 715-717.
29. Taruscio, D. & Mantovani, A. (1998). Human endogenous retroviral sequences: possible roles in reproductive physiopathology. Biol Reprod 59, 713-724.
30. Voisset, C., Bouton, O., Bedin, F., Duret, L., Mandrand, B., Mallet, F. & Paranhos-Baccalà, G. (2000). Chromosomal distribution and coding capacity of the human endogenous retrovirus HERV-W family. AIDS Res Hum Retroviruses 16, 731-740.