Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study

International Journal of Cancer

Volumn 139, Issue 6, 2016, Pages 1261-1269

  Yershova, Katrina ^a   Yuan, Jian Min ^b,c   Wang, Renwei ^b   Valentin, Liza ^d   Watson, Clifford ^d   Gao, Yu Tang ^e   Hecht, Stephen S ^a   Stepanov, Irina ^a,f  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^e SHANGHAI JIAO TONG UNIVERSITY   (China)

^f UNIVERSITY OF MINNESOTA   (United States)

Author keywords

nicotine; nitrate; nitrite; PAH; smoke; tobacco; TSNA

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; BENZO[A]PYRENE; CIGARETTE SMOKE; N' NITROSOANABASINE; N' NITROSOANATABINE; NICOTINE; NITRATE; NITRITE; NITROSAMINE; NITROSONORNICOTINE; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE; UNCLASSIFIED DRUG;

ARTICLE; CHINA; COHORT ANALYSIS; CONTROLLED STUDY; HUMAN; MALE; MOISTURE; PRIORITY JOURNAL; SMOKING; TOBACCO; UNITED STATES; URINALYSIS;

EID: 84977563594     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.30178     Document Type: Article

References (39)

1. Hecht SS. Tobacco carcinogens, their biomarkers, and tobacco-induced cancer. Nat Rev Cancer 2003;3:733–44.
2. International Agency for Research on Cancer. Tobacco smoke and involuntary smoking. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 83. Lyon, France: IARC, 2004.
3. Ding YS, Ashley DL, Watson CH. Determination of 10 carcinogenic polycyclic aromatic hydrocarbons in mainstream cigarette smoke. J Agric Food Chem 2007;55:5966–73.
4. International Agency for Research on Cancer. Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 92. Lyon, France: IARC, 2010. 35–818.
5. Hecht SS. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol 1998;11:559–603.
6. International Agency for Research on Cancer. Smokeless tobacco and some tobacco-specific N-nitrosamines. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 89. Lyon, France: IARC, 2007.
7. Pfeifer GP, Denissenko MF, Olivier M, et al. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene 2002;21:7435–51.
8. Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 1999;91:1194–210.
9. Hecht SS, Murphy SE, Stepanov I, et al. Tobacco smoke biomarkers and cancer risk among male smokers in the Shanghai Cohort Study. Cancer Lett 2012;334:34–8.
10. Yuan JM, Koh WP, Murphy SE, et al. Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. Cancer Res 2009;69:2990–5.
11. Church TR, Anderson KE, Caporaso NE, et al. A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers. Cancer Epidemiol Biomarkers Prev 2009;18:260–6.
12. Yuan JM, Gao YT, Murphy SE, et al. Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers. Cancer Res 2011;71:6749–57.
13. Hecht SS, Carmella SG, Villalta PW, et al. Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies. Chem Res Toxicol 2010;23:900–8.
14. Yuan JM, Knezevich AD, Wang R, et al. Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. Carcinogenesis 2011;32:1366–71.
15. Xiong W, Hou H, Jiang X, et al. Simultaneous determination of four tobacco-specific N-nitrosamines in mainstream smoke for Chinese Virginia cigarettes by liquid chromatography-tandem mass spectrometry and validation under ISO and “Canadian intense” machine smoking regimes. Anal Chim Acta 2010;674:71–8.
16. Wu W, Zhang L, Jain RB, et al. Determination of carcinogenic tobacco-specific nitrosamines in mainstream smoke from U.S.-brand and non-U.S.-brand cigarettes from 14 countries. Nicotine Tob Res 2005;7:443–51.
17. Ding YS, Yan XJ, Jain RB, et al. Determination of 14 polycyclic aromatic hydrocarbons in mainstream smoke from U.S. brand and non-U.S. brand cigarettes. Environ Sci Technol 2006;40:1133–8.
18. Stepanov I, Knezevich A, Zhang L, et al. Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: three decades of remarkable neglect by the tobacco industry. Tobacco Control 2012;21:44–8.
19. Stepanov I, Villalta PW, Knezevich A, et al. Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometry. Chem Res Toxicol 2010;23:66–73.
20. Murphy SE, Villalta P, Ho SW, et al. Analysis of [3',3'-d(2)]-nicotine and [3',3'-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007;857:1–8.
21. Stepanov I, Hecht SS, Ramakrishnan S, et al. Tobacco-specific nitrosamines in smokeless tobacco products marketed in India. Intl J Cancer 2005;116:16–19.
22. Stepanov I, Jensen J, Hatsukami D, et al. New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels. Nicotine Tob Res 2008;10:1773–82.
23. Hoffmann D, Adams JD, Brunnemann KD, et al. Assessment of tobacco-specific N-nitrosamines in tobacco products. Cancer Res 1979;39:2505–9.
24. Borgerding MF, Bodnar JA, Wingate DE. The 1999 Massachusetts Benchmark Study—final report. A research study conducted after consultation with the Massachusetts Department of Public Health. Available at: https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/#id=rfdx0057. 2000.
25. Counts ME, Hsu FS, Laffoon SW, et al. Mainstream smoke constituent yields and predicting relationships from a worldwide market sample of cigarette brands: ISO smoking conditions. Regul Toxicol Pharmacol 2004;39:111–34.
26. Akpan V, Huang S, Lodovici M, et al. High levels of carcinogenic polycyclic aromatic hydrocarbons (PAH) in 20 brands of Chinese cigarettes. J Appl Toxicol 2006;26:480–3.
27. Hoffmann D, Hecht SS, Ornaf RM, et al. Nitrosonornicotine: presence in tobacco, formation and carcinogenicity. In: Walker EA, Bogovski P, Griciute L, eds. Environmental N-nitroso compounds: analysis and formation. Lyon, France: International Agency for Research on Cancer, 1976. 307–20.
28. Hecht SS, Chen CB, Dong M, et al. Studies on non-volatile nitrosamines in tobacco. Beitr Tabakforsch Int 1977;9:1–6.
29. Ding YS, Zhang L, Jain RB, et al. Levels of tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons in mainstream smoke from different tobacco varieties. Cancer Epidemiol Biomarkers Prev 2008;17:3366–71.
30. Fischer S, Spiegelhalder B, Eisenbarth J, et al. Investigations on the origin of tobacco-specific nitrosamines in mainstream smoke of cigarettes. Carcinogenesis 1990;11:723–30.
31. Hecht SS. It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco. Cancer Prev Res 2014;7:639–47.
32. Stepanov I, Carmella SG, Briggs A, et al. Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products. Cancer Res 2009;69:8236–40.
33. Hatsukami DK, Kotlyar M, Hertsgaard LA, et al. Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation. Addiction 2010;105:343–55.
34. Kotlyar M, Hertsgaard LA, Lindgren BR, et al. Effect of oral snus and medicinal nicotine in smokers on toxicant exposure and withdrawal symptoms: a feasibility study. Cancer Epidemiol Biomarkers Prev 2011;20:91–100.
35. Ashley DL, O'Connor RJ, Bernert JT, et al. Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers. Cancer Epidemiol Biomarkers Prev 2010;19:1389–98.
36. Hecht SS, Chen M, Yagi H, et al. r−1,t−2,3,c−4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in human urine: a potential biomarker for assessing polycyclic aromatic hydrocarbon metabolic activation. Cancer Epidemiol Biomarkers Prev 2003;12:1501–8.
37. Hecht SS, Chen M, Yoder A, et al. Longitudinal study of urinary phenanthrene metabolite ratios: effect of smoking on the diol epoxide pathway. Cancer Epidemiol Biomarkers Prev 2005;14:2969–74.
38. Hecht SS, Carmella SG, Yoder A, et al. Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers. Cancer Epidemiol Biomarkers Prev 2006;15:1805–11.
39. Kensler TW, Ng D, Carmella SG, et al. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis 2012;33:101–7.