Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers

Cancer Research

Volumn 71, Issue 21, 2011, Pages 6749-6757

  Yuan, Jian Min ^a,b,c   Gao, Yu Tang ^d   Murphy, Sharon E ^a   Carmella, Steven G ^a   Wang, Renwei ^a   Zhong, Yan ^a   Moy, Kristin A ^a   Davis, Andrew B ^a   Tao, Li ^a   Chen, Menglan ^a   Han, Shaomei ^a   Nelson, Heather H ^a,b   Yu, Mimi C ^a   Hecht, Stephen S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d SHANGHAI CANCER INSTITUTE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL GLUCURONIDE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; BIOLOGICAL MARKER; CIGARETTE SMOKE; COTININE; COTININE N GLUCURONIDE; GLUCURONIDE; NICOTINE; PHENANTHRENE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER RISK; CASE CONTROL STUDY; CIGARETTE SMOKING; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; LUNG SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MALE; METABOLITE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; URINE LEVEL;

AGED; CHINA; COTININE; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NICOTINE; NITROSAMINES; PHENANTHRENES; PROSPECTIVE STUDIES; PYRIDINES; SMOKE; SMOKING; TOBACCO;

EID: 80355139536     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-0209     Document Type: Article

References (42)

1. IARC. Tobacco smoke and involuntary smoking. In: Monographs on the evaluation of carcinogenic risk to humans, vol. 83. Lyon (France): International Agency for Research on Cancer; 2004.
2. Hecht SS. Research opportunities related to establishing standards for tobacco products under the family smoking prevention and tobacco control act. Nicotine Tob Res 2011 Jan 10. [Epub ahead of print].
3. Rodgman A, Perfetti TA. The chemical components of tobacco and tobacco smoke. Boca Raton (FL): CRC Press; 2009. p. 55-100.
4. Stanton MF, Miller E, Wrench C, Blackwell R. Experimental induction of epidermoid carcinoma in the lungs of rats by cigarette smoke condensate. J Natl Cancer Inst 1972;49:867-77.
5. Hoffmann D, Wynder EL.A study of tobacco carcinogenesis. XI. Tumor initiators, tumor accelerators, and tumor promoting activity of condensate fractions. Cancer 1971;27:848-64.
6. Smith LE, Denissenko MF, Bennett WP, Li H, Amin S, Tang M, et al. Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. J Natl Cancer Inst 2000;92:803-11. (Pubitemid 30368036)
7. IARC. Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures In: Monographs on the evaluation of carcinogenic risks to humans, vol. 92. Lyon (France): International Agency for Reseach on Cancer; 2010. p. 99-106.
8. Church TR, Anderson KE, Caporaso NE, Geisser MS, Le CT, Zhang Y, et al. A prospectively measured serum biomarker for a tobaccospecific carcinogen and lung cancer in smokers. Cancer Epidemiol Biomarkers Prev 2009;18:260-6.
9. Yuan JM, Koh WP, Murphy SE, Fan Y, Wang R, Carmella SG, et al. Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers. Cancer Res 2009;69:2990-5.
10. Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson KP, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 2008;452:638-42. (Pubitemid 351483366)
11. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 2008;452:633-7. (Pubitemid 351483367)
12. Wang J, Spitz MR, Amos CI, Wilkinson AV, Wu X, Shete S. Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk. Cancer 2010;116:3458-62.
13. de Waard F, Kemmeren JM, van Ginkel LA, Stolker AA. Urinary cotinine and lung cancer risk in a female cohort. Br J Cancer 1995;72:784-7.
14. Boffetta P, Clark S, Shen M, Gislefoss R, Peto R, Andersen A. Serum cotinine level as predictor of lung cancer risk. Cancer Epidemiol Biomarkers Prev 2006;15:1184-8.
15. Ross RK, Yuan JM, Yu MC, Wogan GN, Qian GS, Tu JT, et al. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 1992;339:943-6.
16. Yuan JM, Ross RK, Wang XL, Gao YT, Henderson BE, Yu MC. Morbidity and mortality in relation to cigarette smoking in Shanghai, China. A prospective male cohort study. JAMA 1996;275:1646-50. (Pubitemid 26175811)
17. Hecht SS, Chen M, Yagi H, Jerina DM, Carmella SG. r-1,t-2,3,c-4- Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in human urine: a potential biomarker for assessing polycyclic aromatic hydrocarbon metabolic activation. Cancer Epidemiol Biomarkers Prev 2003;12: 1501-8. (Pubitemid 38031755)
18. Hecht SS, Carmella SG, Murphy SE. Effects of watercress consumption on urinary metabolites of nicotine in smokers. Cancer Epidemiol Biomarkers Prev 1999;8:907-13. (Pubitemid 29508727)
19. Murphy SE, Villalta P, Ho SW, von Weymarn LB. Analysis of [3′,3′-d(2)]- nicotine and [3′,3′-d(2)]-cotinine by capillary liquid chromatographyelectrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007;857:1-8. (Pubitemid 47362853)
20. Winer BJ. Statistical principles in experimental design, 2nd ed. New York: McGraw-Hill; 1971.
21. Breslow NE, Day NE. Statistical methods in cancer research. Volume 1- The analysis of case-control studies, vol. 32 Lyon (France): IARC Scientific Publication; 1980. p. 192-279.
22. Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 1999;91:1194-210. (Pubitemid 29357186)
23. Hecht SS. Tobacco carcinogens, their biomarkers and tobaccoinduced cancer. Nat Rev Cancer 2003;3:733-44. (Pubitemid 37328812)
24. Luch A, Baird WM. Metabolic activation and detoxification of polycyclic aromatic hydrocarbons. In: Luch A, editor. The carcinogenic effects of polycyclic aromatic hydrocarbons. London: Imperial College Press; 2005. p. 19-96.
25. Kim JH, Sherman ME, Curriero FC, Guengerich FP, Strickland PT, Sutter TR. Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers. Toxicol Appl Pharmacol 2004;199:210-9. (Pubitemid 39208722)
26. Shimada T, Hayes CL, Yamazaki H, Amin S, Hecht SS, Guengerich FP, et al. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res 1996;56:2979-84. (Pubitemid 26199741)
27. Shimada T, Gillam EM, Oda Y, Tsumura F, Sutter TR, Guengerich FP, et al. Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[ a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Chem Res Toxicol 1999;12:623-9. (Pubitemid 29354745)
28. Baird WM, Ralston SL. Carcinogenic polycyclic aromatic hydrocarbons. In: Bowden GT, Fischer SM, editors. Comprehensive toxicology: chemical carcinogens and anticarcinogens, vol. 12. NewYork: Elsevier Science Ltd; 1997. p. 171-200.
29. Cooper CS, Grover PL, Sims P. The metabolism and activation of benzo(a)pyrene. Prog Drug Metab 1983;7:295-396.
30. Szeliga J, Dipple A. DNA adduct formation by polycyclic aromatic hydrocarbon dihydrodiol epoxides. Chem Res Toxicol 1998;11:1-11. (Pubitemid 28065267)
31. Simpson CD, Wu MT, Christiani DC, Santella RM, Carmella SG, Hecht SS. Determination of r-7,t-8,9,c-10-tetrahydroxy-7,8,9, 10-tetrahydrobenzo[ a]pyrene in human urine by gas chromatography/negative ion chemical ionization/mass spectrometry. Chem Res Toxicol 2000;13:271-80. (Pubitemid 30241654)
32. Zhong Y, Carmella SG, Hochalter JB, Balbo S, Hecht SS. Analysis of r-7,t-8,9,c-10-tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine: a biomarker for directly assessing carcinogenic polycyclic aromatic hydrocarbon exposure plus metabolic activation. Chem Res Toxicol. In press 2011.
33. Hochalter JB, Zhong Y, Han S, Carmella SG, Hecht SS. Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene. Chem Res Toxicol 2011;24:262-8.
34. LaVoie EJ, Rice EJ. Structure-activity relationships among tricyclic polynuclear aromatic hydrocarbons. In: Yang SK, Sliverman BD, editors. Polycyclic aromatic hydrocarbon carcinogenesis: structureactivity relationships, vol. 1. Boca Raton (FL): CRC Press; 1988. p. 151-75.
35. Shou M, Korzekwa KR, Krausz KW, Crespi CL, Gonzalez FJ, Gelboin HV. Regio- and stereo-selective metabolism of phenanthrene by twelve cDNA-expressed human, rodent, and rabbit cytochromes P-450. Cancer Lett 1994;83:305-13. (Pubitemid 24253553)
36. Hecht SS, Chen M, Yoder A, Jensen J, Hatsukami D, Le C, et al. Longitudinal study of urinary phenanthrene metabolite ratios: effect of smoking on the diol epoxide pathway. Cancer Epidemiol Biomarkers Prev 2005;14:2969-74. (Pubitemid 43068832)
37. Wu MT, Simpson CD, Christiani DC, Hecht SS. Relationship of exposure to coke-oven emissions and urinary metabolites of benzo(a) pyrene and pyrene in coke-oven workers. Cancer Epidemiol Biomarkers Prev 2002;11:311-4. (Pubitemid 34327011)
38. Mumford JL, Li X, Hu F, Lu XB, Chuang JC. Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from Xuan Wei, China with high lung cancer mortality associated with exposure to unvented coal smoke. Carcinogenesis 1995;16:3031-6. (Pubitemid 26004202)
39. Mumford JL, He XZ, Chapman RS, Cao SR, Harris DB, Li XM, et al. Lung cancer and indoor air pollution in Xuan Wei, China. Science 1987;235:217-20.
40. Xiong W, Hou H, Jiang X, Tang G, Hu Q. Simultaneous determination of four tobacco-specific N-nitrosamines in mainstream smoke for Chinese Virginia cigarettes by liquid chromatography-tandemmass spectrometry and validation under ISO and "Canadian intense" machine smoking regimes. Anal Chim Acta 2010;674:71-8.
41. Xia Y, Bernert JT, Jain RB, Ashley DL, Pirkle JL. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in smokers in the United States: NHANES 2007-2008. Biomarkers 2011;16:112-9.
42. Church TR, Anderson KE, Le C, Zhang Y, Kampa DM, Benoit AR, et al. Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers. Biomarkers 2010;15:345-52.