Integrated long non-coding RNA analyses identify novel regulators of epithelial-mesenchymal transition in the mouse model of pulmonary fibrosis

Journal of Cellular and Molecular Medicine

Volumn 20, Issue 7, 2016, Pages 1234-1246

  Sun, Hao ^a   Chen, Junjie ^a,b   Qian, Wenyi ^c   Kang, Jiang ^a   Wang, Jun ^c   Jiang, Lei ^a   Qiao, Li ^a   Chen, Wei ^d   Zhang, Jinsong ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b YIXING PEOPLE S HOSPITAL   (China)

^c Nanjing Medical University   (China)

^d THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

epithelial mesenchymal transition; long non coding RNA; paraquat; pulmonary fibrosis

Indexed keywords

HYDROXYPROLINE; LONG UNTRANSLATED RNA; PARAQUAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; CELL STRUCTURE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENE ONTOLOGY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LUNG FIBROSIS; MALE; MICROARRAY ANALYSIS; MICROSCOPY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITY CONTROL; RNA EXTRACTION; WESTERN BLOTTING;

EID: 84977490143     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12783     Document Type: Article

References (33)

1. King TE, Pardo A, Selman M. Idiopathic pulmonary fibrosis. Lancet. 2011; 378: 1949–61.
2. Fernandez IE, Eickelberg O. New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis. Lancet. 2012; 380: 680–8.
3. Mouratis MA, Aidinis V. Modeling pulmonary fibrosis with bleomycin. Curr Opin Pulm Med. 2011; 17: 355–61.
4. Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, et al. Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol. 2008; 38: 13–71.
5. Copland GM, Kolin A, Shulman HS. Fatal pulmonary intra-alveolar fibrosis after paraquat ingestion. N Engl J Med. 1974; 291: 290–2.
6. Dong J, Yu X, Porter DW, et al. Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents. Arch Toxicol. 2015; 7. Doi:10.1007/s00204-015-1589-3.
7. Coward WR, Saini G, Jenkins G. The pathogenesis of idiopathic pulmonary fibrosis. Ther Adv Respir Dis. 2010; 4: 367–88.
8. Kim KK, Kugler MC, Wolters PJ, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA. 2006; 103: 13180–5.
9. Tanjore H, Xu XC, Polosukhin VV, et al. Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am J Respir Crit Care Med. 2009; 180: 657–65.
10. Tang N, Zhao Y, Feng R, et al. Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts. J Cell Mol Med. 2014; 18: 156–69.
11. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119: 1420–8.
12. Kage H, Borok Z. EMT and interstitial lung disease: a mysterious relationship. Curr Opin Pulm Med. 2012; 18: 517–23.
13. Hannon GJ, Rivas FV, Murchison EP, et al. The expanding universe of noncoding RNAs. Cold Spring Harb Symp Quant Biol. 2006; 71: 551–64.
14. Sabin LR, Delás MJ, Hannon GJ. Dogma derailed: the many influences of RNA on the genome. Mol Cell. 2013; 49: 783–94.
15. Pandit KV, Milosevic J, Kaminski N. MicroRNAs in idiopathic pulmonary fibrosis. Transl Res. 2011; 157: 191–9.
16. Balakrishnan R, Harris MA, Huntley R, et al. A guide to best practices for Gene Ontology (GO) manual annotation. Database. 2013; 9: bat054.
17. Brabletz S, Brabletz T. The ZEB/miR-200 feedback loop-a motor of cellular plasticity in development and cancer? EMBO Rep. 2010; 11: 670–7.
18. Chisaka O, Kameda Y. Hoxa3 regulates the proliferation and differentiation of the third pharyngeal arch mesenchyme in mice. Cell Tissue Res. 2005; 320: 77–89.
19. Manley NR, Capecchi MR. Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev Biol. 1997; 192: 274–88.
20. Batista PJ, Chang HY. Long noncoding RNAs: cellular address codes in development and disease. Cell. 2013; 152: 1298–307.
21. Cao G, Zhang J, Wang M, et al. Differential expression of long non-coding RNAs in bleomycin-induced lung fibrosis. Int J Mol Med. 2013; 32: 355–64.
22. Song X, Cao G, Jing L, et al. Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis. J Cell Mol Med. 2014; 18: 991–1003.
23. Smith P, Heath D. The ultrastructure and time sequence of the early stages of paraquat lung in rats. J Pathol. 1974; 114: 177–84.
24. Smith P, Heath D, Kay JM. The pathogenesis and structure of paraquat-induced pulmonary fibrosis in rats. J Pathol. 1974; 114: 57–67.
25. Smith P, Heath D. Paraquat lung: a reappraisal. Thorax. 1974; 29: 643–53.
26. Kim T, Veronese A, Pichiorri F, et al. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med. 2011; 208: 875–83.
27. Das S, Becker BN, Hoffmann FM, et al. Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway. BMC Cell Biol. 2009; 10: 94.
28. Mace KA, Hansen SL, Myers C, et al. HOXA3 induces cell migration in endothelial and epithelial cells promoting angiogenesis and wound repair. J Cell Sci. 2005; 118: 2567–77.
29. Mace KA, Restivo TE, Rinn JL, et al. HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells. 2009; 27: 1654–65.
30. Gupta RA, Shah N, Wang KC, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010; 464: 1071–6.
31. Feng J, Bi C, Clark BS, et al. The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Genes Dev. 2006; 20: 1470–84.
32. Yamada A, Aki T, Unuma K, et al. Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells. PLoS ONE. 2015; 10: e0120192. Doi:10.1371/journal.pone.0120192.
33. Huang M, Wang YP, Zhu LQ, et al. MAPK pathway mediates epithelial-mesenchymal transition induced by paraquat in alveolar epithelial cells. Environ Toxicol. 2015; 15. Doi:10.1002/tox.22146.