Multiple layers of transcriptional regulation by PLZF in NKT-cell development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 27, 2016, Pages 7602-7607

  Mao, Ai Ping ^a   Constantinides, Michael G ^a   Mathew, Rebecca ^a   Zuo, Zhixiang ^b   Chen, Xiaoting ^b,c   Weirauch, Matthew T ^b,c   Bendelac, Albert ^a,d  

^a UNIVERSITY OF CHICAGO   (United States)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Development; Lymphocyte; NKT; PLZF

Indexed keywords

CYTOKINE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PLZF; UNCLASSIFIED DRUG; BACH2 PROTEIN, MOUSE; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CHEMOKINE RECEPTOR; CYTOKINE; KRUPPEL LIKE FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR RUNX; ZBTB16 PROTEIN, MOUSE;

ADHESION; ANIMAL CELL; ARTICLE; BIOTINYLATION; CELL DIFFERENTIATION; CELL HOMING; CELL MATURATION; CONTROLLED STUDY; MICROARRAY ANALYSIS; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REPRESSOR GENE; THYMOCYTE; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; GENE EXPRESSION REGULATION; HELPER CELL; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS); TRANSGENIC MOUSE;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CORE BINDING FACTOR ALPHA SUBUNITS; CYTOKINES; GENE EXPRESSION REGULATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE, INBRED C57BL; MICE, TRANSGENIC; NATURAL KILLER T-CELLS; PROTO-ONCOGENE PROTEINS C-ETS; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84977272865     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1601504113     Document Type: Article

References (44)

1. Constantinides MG, Bendelac A (2013) Transcriptional regulation of the NKT cell lineage. Curr Opin Immunol 25(2):161-167.
2. Godfrey DI, Uldrich AP, McCluskey J, Rossjohn J, Moody DB (2015) The burgeoning family of unconventional T cells. Nat Immunol 16(11):1114-1123.
3. Gapin L (2016) Development of invariant natural killer T cells. Curr Opin Immunol 39:68-74.
4. Savage AK, et al. (2008) The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29(3):391-403.
5. Thomas SY, et al. (2011) PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med 208(6):1179-1188.
6. Kovalovsky D, et al. (2008) The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol 9(9):1055-1064.
7. Raberger J, et al. (2008) The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells. Proc Natl Acad Sci USA 105(46):17919-17924.
8. Kreslavsky T, et al. (2009) TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci USA 106(30):12453-12458.
9. Savage AK, Constantinides MG, Bendelac A (2011) Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol 186(10):5801-5806.
10. Kovalovsky D, et al. (2010) PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals. J Immunol 184(12):6746-6755.
11. Constantinides MG, McDonald BD, Verhoef PA, Bendelac A (2014) A committed precursor to innate lymphoid cells. Nature 508(7496):397-401.
12. Verhoef PA, et al. (2016) Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol 137(2):591-600.e1.
13. Gleimer M, von Boehmer H, Kreslavsky T (2012) PLZF controls the expression of a limited number of genes essential for NKT cell function. Front Immunol 3:374.
14. Samstein RM, et al. (2012) Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell 151(1):153-166.
15. Wei G, et al. (2011) Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity 35(2):299-311.
16. Seiler MP, et al. (2012) Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. Nat Immunol 13(3):264-271.
17. Furley AJ, et al. (1986) Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines. Blood 68(5):1101-1107.
18. Cohen NR, et al.; ImmGen Project Consortium (2013) Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol 14(1):90-99.
19. Matsuda JL, et al. (2006) T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells. Blood 107(7):2797-2805.
20. Hart GT, Wang X, Hogquist KA, Jameson SC (2011) Krüppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression. Proc Natl Acad Sci USA 108(2):716-721.
21. Takada K, et al. (2011) Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells. J Immunol 186(2):775-783.
22. Subleski JJ, et al. (2011) TCR-dependent and -independent activation underlie liverspecific regulation of NKT cells. J Immunol 186(2):838-847.
23. Velázquez P, et al. (2008) Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids. J Immunol 180(4):2024-2028.
24. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB (2003) Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 4(12):1230-1237.
25. Leite-De-Moraes MC, et al. (2001) IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: A pro-Th2 effect of IL-18 exerted through NKT cells. J Immunol 166(2):945-951.
26. Globisch T, et al. (2014) Cytokine-dependent regulation of dendritic cell differentiation in the splenic microenvironment. Eur J Immunol 44(2):500-510.
27. Hedl M, Lahiri A, Ning K, Cho JH, Abraham C (2014) Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele. Immunity 40(5):734-746.
28. Bai L, et al. (2013) Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proc Natl Acad Sci USA 110(40):16097-16102.
29. Vahedi G, et al. (2015) Super-enhancers delineate disease-associated regulatory nodes in T cells. Nature 520(7548):558-562.
30. Roychoudhuri R, et al. (2013) BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature 498(7455):506-510.
31. Tsukumo S, et al. (2013) Bach2 maintains T cells in a naive state by suppressing effector memory-related genes. Proc Natl Acad Sci USA 110(26):10735-10740.
32. Sitterlin D, Tiollais P, Transy C (1997) The RAR alpha-PLZF chimera associated with acute promyelocytic leukemia has retained a sequence-specific DNA-binding domain. Oncogene 14(9):1067-1074.
33. Li JY, et al. (1997) Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein. J Biol Chem 272(36):22447-22455.
34. Doulatov S, et al. (2009) PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes Dev 23(17):2076-2087.
35. Puszyk W, et al. (2013) The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells. EMBO J 32(13):1941-1952.
36. Sadler AJ, et al. (2015) BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci USA 112(5):1535-1540.
37. Walunas TL, Wang B, Wang CR, Leiden JM (2000) Cutting edge: The Ets1 transcription factor is required for the development of NK T cells in mice. J Immunol 164(6):2857-2860.
38. D'Cruz LM, Stradner MH, Yang CY, Goldrath AW (2014) E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation. J Immunol 192(5):2227-2236.
39. Egawa T, et al. (2005) Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22(6):705-716.
40. Mathew R, et al. (2012) BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature 491(7425):618-621.
41. Alonzo ES, et al. (2010) Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. JImmunol 184(3):1268-1279.
42. Griewank K, et al. (2007) Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 27(5):751-762.
43. Machanick P, Bailey TL (2011) MEME-ChIP: Motif analysis of large DNA datasets. Bioinformatics 27(12):1696-1697.
44. Grant CE, Bailey TL, Noble WS (2011) FIMO: Scanning for occurrences of a given motif. Bioinformatics 27(7):1017-1018.