BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 5, 2015, Pages 1535-1540

  Sadler, Anthony J ^a,b   Rossello, Fernando J ^a,b,c   Yu, Liang ^a,b   Deane, James A ^a,b   Yuan, Xiangliang ^d   Wang, Die ^a,b   Irving, Aaron T ^a   Kaparakis Liaskos, Maria ^a,b   Gantier, Michael P ^a,b   Ying, Hangjie ^a   Yim, Howard C H ^a,b   Hartland, Elizabeth L ^e   Notini, Amanda J ^a,b   De Boer, Suzan ^a   White, Stefan J ^a,b   Mansell, Ashley ^a,b   Liu, Jun Ping ^f   Watkins, D Neil ^a,g   Gerondakis, Steve ^b   Williams, Bryan R G ^a,b   Xu, Dakang ^a,b,f   more..

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c Life Sciences Computation Centre   (Australia)

^d XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f HANGZHOU NORMAL UNIVERSITY   (China)

^g GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Chromatin structure; Inflammation; Transcriptional regulation

Indexed keywords

HISTONE DEACETYLASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P40; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; PROMYELOCYTIC LEUKEMIA ZINC FINGER PROTEIN; PROTEIN P50; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; CHROMATIN; HISTONE DEACETYLASE; KRUPPEL LIKE FACTOR; ZBTB16 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN; CHROMATIN CONDENSATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EARLY RESPONSE GENE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE CONTROL; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HISTONE ACETYLATION; HISTONE MODIFICATION; HOMEOSTASIS; IMMUNOPRECIPITATION; INFLAMMATION; INNATE IMMUNITY; LIVER INJURY; MACROPHAGE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SALMONELLOSIS; WESTERN BLOTTING; ANIMAL; BACTERIAL INFECTION; C57BL MOUSE; CHROMATIN IMMUNOPRECIPITATION; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALIA; POXVIRIDAE;

ANIMALS; BACTERIAL INFECTIONS; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HISTONE DEACETYLASES; INFLAMMATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MACROPHAGES; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84922326344     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409728112     Document Type: Article

References (36)

1. Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol 2(8):675-680.
2. Suntharalingam G, et al. (2006) Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 355(10):1018-1028.
3. Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH (2007) Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade. Science 317(5838):675-678.
4. Medzhitov R, Horng T (2009) Transcriptional control of the inflammatory response. Nat Rev Immunol 9(10):692-703.
5. Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27:693-733.
6. Chevrier N, et al. (2011) Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell 147(4):853-867.
7. Hargreaves DC, Horng T, Medzhitov R (2009) Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138(1):129-145.
8. Ganal SC, et al. (2012) Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity 37(1):171-186.
9. Qiao Y, et al. (2013) Synergistic activation of inflammatory cytokine genes by in-terferon-γ-induced chromatin remodeling and toll-like receptor signaling. Immunity 39(3):454-469.
10. Kovalovsky D, et al. (2008) The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol 9(9):1055-1064.
11. Savage AK, et al. (2008) The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29(3):391-403.
12. Raberger J, et al. (2008) The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells. Proc Natl Acad Sci USA 105(46):17919-17924.
13. Xu D, et al. (2009) Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity 30(6):802-816.
14. Constantinides MG, McDonald BD, Verhoef PA, Bendelac A (2014) A committed precursor to innate lymphoid cells. Nature 508(7496):397-401.
15. Vazquez-Torres A, et al. (2004) Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: Importance of the Kupffer cell network. J Immunol 172(10):6202-6208.
16. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683-765.
17. Escoubet-Lozach L, et al. (2011) Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet 7(12):e1002401.
18. Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1(6):a001651.
19. Sen R, Smale ST (2010) Selectivity of the NF-kappaB response. Cold Spring Harb Perspect Biol 2(4):a000257.
20. Grignani F, et al. (1998) Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 391(6669):815-818.
21. Hong SH, David G, Wong CW, Dejean A, Privalsky ML (1997) SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. Proc Natl Acad Sci USA 94(17):9028-9033.
22. Barish GD, et al. (2010) Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. Genes Dev 24(24):2760-2765.
23. Do-Umehara HC, et al. (2013) Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ. Nat Immunol 14(5):461-469.
24. Natoli G, Saccani S, Bosisio D, Marazzi I (2005) Interactions of NF-kappaB with chromatin: The art of being at the right place at the right time. Nat Immunol 6(5):439-445.
25. Kondo T, Kawai T, Akira S (2012) Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol 33(9):449-458.
26. Byun JS, et al. (2009) Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes. Proc Natl Acad Sci USA 106(46):19286-19291.
27. Quintin J, et al. (2012) Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe 12(2):223-232.
28. Monticelli S, Natoli G (2013) Short-term memory of danger signals and environmental stimuli in immune cells. Nat Immunol 14(8):777-784.
29. Ozato K (2009) PLZF outreach: A finger in interferon's pie. Immunity 30(6):757-758.
30. Guidez F, et al. (2005) Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol 25(13):5552-5566.
31. Baccarini M, Bistoni F, Lohmann-Matthes ML (1985) In vitro natural cell-mediated cytotoxicity against Candida albicans: Macrophage precursors as effector cells. J Immunol 134(4):2658-2665.
32. Dahl JA, Collas P (2008) A rapid micro chromatin immunoprecipitation assay (micro-ChIP). Nat Protoc 3(6):1032-1045.
33. Heinz S, et al. (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38(4):576-589.
34. Kent WJ, et al. (2002) The human genome browser at UCSC. Genome Res 12(6):996-1006.
35. Ulloa L, et al. (2002) Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci USA 99(19):12351-12356.
36. Han C et al. (2010) Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat Immunol 11(8):734-742