Cold-Adapted Proteases as an Emerging Class of Therapeutics

Infectious Diseases and Therapy

Volumn 2, Issue 1, 2013, Pages 15-26

  Fornbacke, Marcus ^a   Clarsund, Mats ^a  

^a Enzymatica AB   (Sweden)

Author keywords

Cold adapted; Proteases; Psychrophiles; Recombinant proteases; Therapeutics

Indexed keywords

ALTEPLASE; ANTIINFLAMMATORY AGENT; BACTERIAL ENZYME; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 9; BOTULINUM TOXIN A; BOTULINUM TOXIN B; CARBOXYPEPTIDASE A; CARBOXYPEPTIDASE B; CHYMOTRYPSIN; COLD ADAPTED PROTEINASE; COLDZYME; COLLAGENASE; COSMETIC; FIBRINOLYTIC AGENT; PANCRELIPASE; PLACEBO; PROCOAGULANT; PROTEINASE; PROTEINASE K; RETEPLASE; STREPTODOMASE; STREPTOKINASE; SUBTILISIN; SUBTILISIN S41; TENECTEPLASE; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG; UROKINASE;

BACTERIAL INFECTION; DERMATOLOGY; HUMAN; NONHUMAN; PERIODONTAL DISEASE; PRIORITY JOURNAL; PSYCHROPHILIC BACTERIUM; REVIEW; SKIN DISEASE; VIRUS INFECTION; WOUND HEALING;

EID: 84977141023     PISSN: 21938229     EISSN: 21936382     Source Type: Journal    
DOI: 10.1007/s40121-013-0002-x     Document Type: Review

References (47)

1. Kuddus M, Ramteke PW. Recent developments in production and biotechnological applications of cold-active microbial proteases. Crit Rev Microbiol. 2012;38: 330-8.
2. Fein H, Maytin EV, Mutasim DF, Bailin PL. Topical protease therapy as a novel method of epidermal ablation: preliminary report. Dermatol Surg. 2005;31: 139-47.
3. Craik CS, Page MJ, Madison EL. Proteases as therapeutics. Biochem J. 2011;435: 1-16.
4. Duffy MJ, McGowan PM, Gallagher WM. Cancer invasion and metastasis: changing views. J Pathol. 2008;214: 283-93.
5. Scott CJ, Taggart CC. Biologic protease inhibitors as novel therapeutic agents. Biochimie. 2010;92: 1681-8.
6. Rawlings ND, Tolle DP, Barrett AJ. Evolutionary families of peptidase inhibitors. Biochem J. 2004;378: 705-16.
7. Morris RT. The action of trypsin, pancreatic extract and pepsin upon sloughs, coagula, and mucopus. NY Med J. 1891;53: 424-6.
8. Morani AD. Trypsin therapy in the management of chronic surface ulcers. Plast Reconstr Surg. 1953;11: 372-9.
9. Rapoport C. The use of trypsin in the therapy of tuberculous lymphadenitis and tuberculous fistulae. Dis Chest. 1958;34: 154-61.
10. Gudmundsdottir A, Palsdottir HM. Atlantic cod trypsins: from basic research to practical applications. Mar Biotechnol. 2005;7: 77-88.
11. Seiberg M, Siock P, Wisniewski S, Cauwenbergh G, Shapiro SS. The effects of trypsin on apoptosis, utriculi size, and skin elasticity in the Rhino mouse. J Investig Dermatol. 1997;109: 370-6.
12. Shi L, Carson D. Collagenase Santyl ointment: a selective agent for wound debridement. J Wound Ostomy Cont Nurs. 2009;36(Suppl.): S12-6.
13. Hellgren L. Cleansing properties of stabilized trypsin and streptokinase-streptodornase in necrotic leg ulcers. Eur J Clin Pharmacol. 1983;24: 623-8.
14. Brooks JL, Jefferson KK. Staphylococcal biofilms: quest for the magic bullet. Adv Appl Microbiol. 2012;81: 63-87.
15. Chaignon P, Sadovskaya I, Ragunah C, Ramasubbu N, Kaplan JB, Jabbouri S. Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition. Appl Microbiol Biotechnol. 2007;75: 125-32.
16. Marti M, Trotonda MP, Tormo-Mas MA, et al. Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus. Microbes Infect. 2010;12: 55-64.
17. Hangler M, Burmolle M, Schneider I, Allermann K, Jensen B. The serine protease Esperase HPF inhibits the formation of multispecies biofilm. Biofouling. 2009;25: 667-74.
18. Siddiqui KS, Cavicchioli R. Cold-adapted enzymes. Ann Rev Biochem. 2006;75: 403-33.
19. Lonhienne T, Gerday C, Feller G. Psychrophilic enzymes: revisiting the thermodynamic parameters of activation may explain local flexibility. Biochim Biophys Acta. 2000;1543: 1-10.
20. Aghajari N, van Petegem F, Villeret V, et al. Crystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold-adapted proteases. Proteins. 2003;50: 636-47.
21. Gerday C, Aittaleb M, Bentahir M, et al. Cold-adapted enzymes: from fundamentals to biotechnology. Trends Biotechnol. 2000;18: 103-7.
22. Asgeirsson B, Fox JW, Bjarnason JB. Purification and characterization of trypsin from the poikilotherm Gadus morhua. Eur J Biochem. 1989;180: 85-94.
23. Osnes KK, Mohr V. On the purification and characterization of three anionic, serine-type peptide hydrolases from antarctic krill, Euphausia superba. Comp Biochem Physiol B. 1985;82: 607-19.
24. Stefansson B, Helgadottir L, Olafsdottir S, Gudmundsdottir A, Bjarnason JB. Characterization of cold-adapted Atlantic cod (Gadus morhua) trypsin I-kinetic parameters, autolysis and thermal stability. Comp Biochem Physiol B: Biochem Mol Biol. 2010;155: 186-94.
25. Leiros HK, Willassen NP, Smalas AO. Structural comparison of psychrophilic and mesophilic trypsins. Elucidating the molecular basis of cold-adaptation. Eur J Biochem. 2000;267: 1039-49.
26. Collins T, Roulling F, Piette F, et al. Fundamentals of cold-adapted enzymes. Psychrophiles: from biodiversity to biotechnology. Berlin: Springer; 2008. p. 211-27.
27. Smalas AO, Leiros HK, Os V, Willassen NP. Cold adapted enzymes. Biotechnol Ann Rev. 2000;6: 1-57.
28. Johannsdottir UB. Activity of Atlantic cod trypsin towards cytokines and other proteins. PhD thesis, University of Iceland; 2009.
29. Huston AL. Biotechnological aspects of cold-adapted enzymes. Psychrophiles: from biodiversity to biotechnology. Berlin: Springer; 2008. p. 347-63.
30. Marx JC, Collins T, D'Amico S, Feller G, Gerday C. Cold-adapted enzymes from marine Antarctic microorganisms. Mar Biotechnol. 2007;9: 293-304.
31. Miyazaki K, Wintrode PL, Grayling RA, Rubingh DN, Arnold FH. Directed evolution study of temperature adaptation in a psychrophilic enzyme. J Mol Biol. 2000;297: 1015-26.
32. Wintrode PL, Miyazaki K, Arnold FH. Patterns of adaptation in a laboratory evolved thermophilic enzyme. Biochim Biophys Acta. 2001;1549: 1-8.
33. Taguchi S, Ozaki A, Momose H. Engineering of a cold-adapted protease by sequential random mutagenesis and a screening system. Appl Environ Microbiol. 1998;64: 492-5.
34. Karan R, Capes MD, Dassarma S. Function and biotechnology of extremophilic enzymes in low water activity. Aquat Biosyst. 2012;8: 4.
35. Lollar P. Mapping factor VIII inhibitor epitopes using hybrid human/porcine factor VIII molecules. Haematologica. 2000;85(Suppl.): 26-8.
36. Macouzet M, Simpson BK, Lee BH. Cloning of fish enzymes and other fish protein genes. Crit Rev Biotechnol. 1999;19: 179-96.
37. Lee SG, Koh HY, Lee HK, Yim JH. Possible roles of Antarctic krill proteases for skin regeneration. Ocean Polar Res. 2008;30: 467-72.
38. Mekkes JR, Le Poole IC, Das PK, Bos JD, Westerhof W. Efficient debridement of necrotic wounds using proteolytic enzymes derived from Antarctic krill: a double-blind, placebo-controlled study in a standardized animal wound model. Wound Repair Regen. 1998;6: 50-7.
39. Berg CH, Kalfas S, Malmsten M, Arnebrant T. Proteolytic degradation of oral biofilms in vitro and in vivo: potential of proteases originating from Euphausia superba for plaque control. Eur J Oral Sci. 2001;109: 316-24.
40. Hellgren K. Assessment of Krillase chewing gum for the reduction of gingivitis and dental plaque. J Clin Dent. 2009;20: 99-102.
41. Hellgren K. Krill enzymes (Krillase) an important factor to improve oral hygiene. In: Virdi MS, editor. Oral health care-pediatric, research, epidemiology and clinical practice. Croatia: InTech; 2012.
42. Wang ES, Dobrikova E, Goetz C, Dufresne AT, Gromeier M. Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract. J Virol. 2011;85: 5606-17.
43. Wat D. The common cold: a review of the literature. Eur J Intern Med. 2004;15: 79-88.
44. D'Angelo M, Visintin JA, Richtzenhain LJ, Goncalves RF. Evaluation of trypsin treatment on the inactivation of bovine herpesvirus type 1 on in vitro produced pre-implantation embryos. Reprod Dom Anim. 2009;44: 536-9.
45. Piirainen L, Hovi T, Roivainen M. Variability in the integrity of human enteroviruses exposed to various simulated in vivo environments. Microb Pathog. 1998;25: 131-7.
46. ColdZyme [product information]. Lund, Sweden: Enzymatica AB; 2011.
47. Hilmarsson H, Stefansson B, Bjarnason JB, Gudmundsdottir A. Virucidal activities of Penzyme against Herpes Simplex veiru type 1 (poster 928). COST (European Cooperation in Science and Technology) 928; March 2-4, 2010; Naples, Italy.