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Volumn 6, Issue , 2016, Pages

Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABA A receptors: Evidence of a novel benzodiazepine site in the α1-α1 interface

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; GABRA1 PROTEIN, HUMAN; GABRB3 PROTEIN, HUMAN; PYRIDINE DERIVATIVE; ZOLPIDEM;

EID: 84977103257     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep28674     Document Type: Article
Times cited : (37)

References (61)
  • 1
    • 0034692175 scopus 로고    scopus 로고
    • GABA-Activated ligand gated ion channels: Medicinal chemistry and molecular biology
    • Chebib, M. & Johnston, G. A. GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology. J Med Chem 43, 1427-1447 (2000).
    • (2000) J Med Chem , vol.43 , pp. 1427-1447
    • Chebib, M.1    Johnston, G.A.2
  • 2
    • 14844323722 scopus 로고    scopus 로고
    • Variations on an inhibitory theme: Phasic and tonic activation of GABA(A) receptors
    • Farrant, M. & Nusser, Z. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci 6, 215-229 (2005).
    • (2005) Nat Rev Neurosci , vol.6 , pp. 215-229
    • Farrant, M.1    Nusser, Z.2
  • 3
    • 33846245154 scopus 로고    scopus 로고
    • Structure, Pharmacology, and function of GABAA receptor subtypes
    • Sieghart, W. Structure, pharmacology, and function of GABAA receptor subtypes. Adv Pharmacol 54, 231-263 (2006).
    • (2006) Adv Pharmacol , vol.54 , pp. 231-263
    • Sieghart, W.1
  • 4
    • 84921306671 scopus 로고    scopus 로고
    • Allosteric modulation of GABAA receptors via multiple drug-binding sites
    • Sieghart, W. Allosteric modulation of GABAA receptors via multiple drug-binding sites. Adv Pharmacol 72, 53-96 (2015).
    • (2015) Adv Pharmacol , vol.72 , pp. 53-96
    • Sieghart, W.1
  • 5
    • 33845883546 scopus 로고    scopus 로고
    • Structural determinants for high-Affinity zolpidem binding to GABAA receptors
    • Sancar, F., Ericksen, S. S., Kucken, A. M., Teissere, J. A. & Czajkowski, C. Structural determinants for high-Affinity zolpidem binding to GABAA receptors. Mol Pharmacol 71, 38-46 (2007).
    • (2007) Mol Pharmacol , vol.71 , pp. 38-46
    • Sancar, F.1    Ericksen, S.S.2    Kucken, A.M.3    Teissere, J.A.4    Czajkowski, C.5
  • 6
    • 56749163600 scopus 로고    scopus 로고
    • Structural requirements for eszopiclone and zolpidem binding to the gamma-Aminobutyric acid type-A (GABAA) receptor are different
    • Hanson, S. M., Morlock, E. V., Satyshur, K. A. & Czajkowski, C. Structural requirements for eszopiclone and zolpidem binding to the gamma-Aminobutyric acid type-A (GABAA) receptor are different. J Med Chem 51, 7243-7252 (2008).
    • (2008) J Med Chem , vol.51 , pp. 7243-7252
    • Hanson, S.M.1    Morlock, E.V.2    Satyshur, K.A.3    Czajkowski, C.4
  • 7
    • 50849097106 scopus 로고    scopus 로고
    • Replacement of histidine in position 105 in the alpha(5) subunit by cysteine stimulates zolpidem sensitivity of alpha(5)beta(2)gamma(2) GABAA receptors
    • Baur, R. & Sigel, E. Replacement of histidine in position 105 in the alpha(5) subunit by cysteine stimulates zolpidem sensitivity of alpha(5)beta(2)gamma(2) GABAA receptors. J Neurochem 103, 2556-2564 (2007).
    • (2007) J Neurochem , vol.103 , pp. 2556-2564
    • Baur, R.1    Sigel, E.2
  • 8
    • 77952675421 scopus 로고    scopus 로고
    • The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes
    • Ramerstorfer, J., Furtmuller, R., Vogel, E., Huck, S. & Sieghart, W. The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. Eur J Pharmacol 636, 18-27 (2010).
    • (2010) Eur J Pharmacol , vol.636 , pp. 18-27
    • Ramerstorfer, J.1    Furtmuller, R.2    Vogel, E.3    Huck, S.4    Sieghart, W.5
  • 9
    • 0037072577 scopus 로고    scopus 로고
    • Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABAA receptor subtypes
    • Sanna, E. et al. Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABAA receptor subtypes. Eur J Pharmacol 451, 103-110 (2002).
    • (2002) Eur J Pharmacol , vol.451 , pp. 103-110
    • Sanna, E.1
  • 10
    • 0036676629 scopus 로고    scopus 로고
    • Mapping of the benzodiazepine recognition site on GABAA receptors
    • Sigel, E. Mapping of the benzodiazepine recognition site on GABAA receptors. Curr Topics Med Chem 2, 833-839 (2002).
    • (2002) Curr Topics Med Chem , vol.2 , pp. 833-839
    • Sigel, E.1
  • 11
    • 0038771238 scopus 로고    scopus 로고
    • Comparative modeling of GABAA receptors: Limits, insights, future developments
    • Ernst, M., Brauchart, D., Boresch, S. & Sieghart, W. Comparative modeling of GABAA receptors: limits, insights, future developments. Neurosci 119, 933-943 (2003).
    • (2003) Neurosci , vol.119 , pp. 933-943
    • Ernst, M.1    Brauchart, D.2    Boresch, S.3    Sieghart, W.4
  • 12
    • 0028117531 scopus 로고
    • Flumazenil antagonizes the central effects of zolpidem, an imidazopyridine hypnotic
    • Patat, A. et al. Flumazenil antagonizes the central effects of zolpidem, an imidazopyridine hypnotic. Clin Pharmacol Ther 56, 430-436 (1994).
    • (1994) Clin Pharmacol Ther , vol.56 , pp. 430-436
    • Patat, A.1
  • 13
    • 45949095605 scopus 로고    scopus 로고
    • Zolpidem improves akinesia, dystonia and dyskinesia in advanced Parkinsons disease
    • Chen, Y. Y., Sy, H. N. & Wu, S. L. Zolpidem improves akinesia, dystonia and dyskinesia in advanced Parkinsons disease. J Clin Neurosci 15, 955-956 (2008).
    • (2008) J Clin Neurosci , vol.15 , pp. 955-956
    • Chen, Y.Y.1    Sy, H.N.2    Wu, S.L.3
  • 14
    • 84908074957 scopus 로고    scopus 로고
    • GABA-mediated changes in inter-hemispheric beta frequency activity in early-stage Parkinsons disease
    • Hall, S. D. et al. GABA-mediated changes in inter-hemispheric beta frequency activity in early-stage Parkinsons disease. Neurosci 281C, 68-76 (2014).
    • (2014) Neurosci 281C , pp. 68-76
    • Hall, S.D.1
  • 15
    • 84926005809 scopus 로고    scopus 로고
    • Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons
    • Prokic, E. J. et al. Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons. Neuropharmacol 95, 192-205 (2015).
    • (2015) Neuropharmacol , vol.95 , pp. 192-205
    • Prokic, E.J.1
  • 16
    • 3342931170 scopus 로고    scopus 로고
    • Transient improvement of spinocerebellar ataxia with zolpidem
    • Clauss, R., Sathekge, M. & Nel, W. Transient improvement of spinocerebellar ataxia with zolpidem. New Eng J Med 351, 511-512 (2004).
    • (2004) New Eng J Med , vol.351 , pp. 511-512
    • Clauss, R.1    Sathekge, M.2    Nel, W.3
  • 17
    • 84977110246 scopus 로고    scopus 로고
    • Trial of Zolpidem, Eszopiclone, and Other GABA Agonists in a Patient with Progressive Supranuclear Palsy
    • Chang, A. Y. & Weirich, E. Trial of Zolpidem, Eszopiclone, and Other GABA Agonists in a Patient with Progressive Supranuclear Palsy. Case Rep Med 2014, 107064 (2014).
    • (2014) Case Rep Med 2014 , pp. 107064
    • Chang, A.Y.1    Weirich, E.2
  • 18
    • 21444435094 scopus 로고    scopus 로고
    • Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation
    • Cope, D. W. et al. Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation. Eur J Neurosci 21, 3002-3016 (2005).
    • (2005) Eur J Neurosci , vol.21 , pp. 3002-3016
    • Cope, D.W.1
  • 19
    • 84881650157 scopus 로고    scopus 로고
    • Benzodiazepine-site pharmacology on GABAA receptors in histaminergic neurons
    • May, A. C., Fleischer, W., Kletke, O., Haas, H. L. & Sergeeva, O. A. Benzodiazepine-site pharmacology on GABAA receptors in histaminergic neurons. Br J Pharmacol 170, 222-232 (2013).
    • (2013) Br J Pharmacol , vol.170 , pp. 222-232
    • May, A.C.1    Fleischer, W.2    Kletke, O.3    Haas, H.L.4    Sergeeva, O.A.5
  • 20
    • 77952885488 scopus 로고    scopus 로고
    • Zolpidem modulation of phasic and tonic GABA currents in the rat dorsal motor nucleus of the vagus
    • Gao, H. & Smith, B. N. Zolpidem modulation of phasic and tonic GABA currents in the rat dorsal motor nucleus of the vagus. Neuropharmacol 58, 1220-1227 (2010).
    • (2010) Neuropharmacol , vol.58 , pp. 1220-1227
    • Gao, H.1    Smith, B.N.2
  • 21
    • 31044456936 scopus 로고    scopus 로고
    • Pharmacological properties of GABAA receptors containing gamma1 subunits
    • Khom, S. et al. Pharmacological properties of GABAA receptors containing gamma1 subunits. Mol Pharmacol 69, 640-649 (2006).
    • (2006) Mol Pharmacol , vol.69 , pp. 640-649
    • Khom, S.1
  • 22
    • 0030611649 scopus 로고    scopus 로고
    • A point mutation in the gamma2 subunit of gamma-Aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity
    • Buhr, A. & Sigel, E. A point mutation in the gamma2 subunit of gamma-Aminobutyric acid type A receptors results in altered benzodiazepine binding site specificity. Proc Nat Acad Sci 94, 8824-8829 (1997).
    • (1997) Proc Nat Acad Sci , vol.94 , pp. 8824-8829
    • Buhr, A.1    Sigel, E.2
  • 23
    • 0033561229 scopus 로고    scopus 로고
    • Single-channel properties of synaptic and extrasynaptic GABAA receptors suggest differential targeting of receptor subtypes
    • Brickley, S. G., Cull-Candy, S. G. & Farrant, M. Single-channel properties of synaptic and extrasynaptic GABAA receptors suggest differential targeting of receptor subtypes. J Neurosci 19, 2960-2973 (1999).
    • (1999) J Neurosci , vol.19 , pp. 2960-2973
    • Brickley, S.G.1    Cull-Candy, S.G.2    Farrant, M.3
  • 24
    • 0036673411 scopus 로고    scopus 로고
    • Subunit composition, distribution and function of GABAA receptor subtypes
    • Sieghart, W. & Sperk, G. Subunit composition, distribution and function of GABAA receptor subtypes. Curr Topics Med Chem 2, 795-816 (2002).
    • (2002) Curr Topics Med Chem , vol.2 , pp. 795-816
    • Sieghart, W.1    Sperk, G.2
  • 25
    • 33845345567 scopus 로고    scopus 로고
    • Extrasynaptic alphabeta subunit GABAA receptors on rat hippocampal pyramidal neurons
    • Mortensen, M. & Smart, T. G. Extrasynaptic alphabeta subunit GABAA receptors on rat hippocampal pyramidal neurons. J Physiol 577, 841-856 (2006).
    • (2006) J Physiol , vol.577 , pp. 841-856
    • Mortensen, M.1    Smart, T.G.2
  • 26
    • 0033538546 scopus 로고    scopus 로고
    • A significant part of native gamma-Aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunits
    • Bencsits, E., Ebert, V., Tretter, V. & Sieghart, W. A significant part of native gamma-Aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunits. J Biol Chem 274, 19613-19616 (1999).
    • (1999) J Biol Chem , vol.274 , pp. 19613-19616
    • Bencsits, E.1    Ebert, V.2    Tretter, V.3    Sieghart, W.4
  • 27
    • 0842288717 scopus 로고    scopus 로고
    • Autoradiographic imaging of altered synaptic alphabetagamma2 and extrasynaptic alphabeta GABAA receptors in a genetic mouse model of anxiety
    • Sinkkonen, S. T., Luscher, B., Luddens, H. & Korpi, E. R. Autoradiographic imaging of altered synaptic alphabetagamma2 and extrasynaptic alphabeta GABAA receptors in a genetic mouse model of anxiety. Neurochem Int 44, 539-547 (2004).
    • (2004) Neurochem Int , vol.44 , pp. 539-547
    • Sinkkonen, S.T.1    Luscher, B.2    Luddens, H.3    Korpi, E.R.4
  • 28
    • 0033623608 scopus 로고    scopus 로고
    • Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms
    • Walters, R. J., Hadley, S. H., Morris, K. D. & Amin, J. Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms. Nat. Neurosci. 3, 1274-1281 (2000).
    • (2000) Nat. Neurosci , vol.3 , pp. 1274-1281
    • Walters, R.J.1    Hadley, S.H.2    Morris, K.D.3    Amin, J.4
  • 29
    • 50849139862 scopus 로고    scopus 로고
    • Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs
    • Baur, R. et al. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs. J Neurochem 106, 2353-2363 (2008).
    • (2008) J Neurochem , vol.106 , pp. 2353-2363
    • Baur, R.1
  • 30
    • 78751497286 scopus 로고    scopus 로고
    • The GABAA receptor alpha + beta-interface: A novel target for subtype selective drugs
    • Ramerstorfer, J. et al. The GABAA receptor alpha + beta-interface: A novel target for subtype selective drugs. J Neurosci 31, 870-877 (2011).
    • (2011) J Neurosci , vol.31 , pp. 870-877
    • Ramerstorfer, J.1
  • 31
    • 0030900731 scopus 로고    scopus 로고
    • Stoichiometry and assembly of a recombinant GABAA receptor subtype
    • Tretter, V., Ehya, N., Fuchs, K. & Sieghart, W. Stoichiometry and assembly of a recombinant GABAA receptor subtype. J Neurosci 17, 2728-2737 (1997).
    • (1997) J Neurosci , vol.17 , pp. 2728-2737
    • Tretter, V.1    Ehya, N.2    Fuchs, K.3    Sieghart, W.4
  • 32
    • 0033537884 scopus 로고    scopus 로고
    • Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer
    • Farrar, S. J., Whiting, P. J., Bonnert, T. P. & McKernan, R. M. Stoichiometry of a ligand-gated ion channel determined by fluorescence energy transfer. J Biol Chem 274, 10100-10104 (1999).
    • (1999) J Biol Chem , vol.274 , pp. 10100-10104
    • Farrar, S.J.1    Whiting, P.J.2    Bonnert, T.P.3    McKernan, R.M.4
  • 33
    • 30544440725 scopus 로고    scopus 로고
    • Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-Associated protein
    • Boileau, A. J., Pearce, R. A. & Czajkowski, C. Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-Associated protein. J Neurosci 25, 11219-11230 (2005).
    • (2005) J Neurosci , vol.25 , pp. 11219-11230
    • Boileau, A.J.1    Pearce, R.A.2    Czajkowski, C.3
  • 34
    • 79960953776 scopus 로고    scopus 로고
    • Unraveling the high-and low-sensitivity agonist responses of nicotinic acetylcholine receptors
    • Harpsoe, K. et al. Unraveling the high-and low-sensitivity agonist responses of nicotinic acetylcholine receptors. J Neurosci 31, 10759-10766 (2011).
    • (2011) J Neurosci , vol.31 , pp. 10759-10766
    • Harpsoe, K.1
  • 35
    • 84922381735 scopus 로고    scopus 로고
    • Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-Affinity alpha4-Alpha4 interface
    • Ahring, P. K. et al. Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-Affinity alpha4-Alpha4 interface. Neuropharmacol 92, 135-145 (2015).
    • (2015) Neuropharmacol , vol.92 , pp. 135-145
    • Ahring, P.K.1
  • 36
    • 84949938484 scopus 로고    scopus 로고
    • The Direct Actions of GABA, 2?-Methoxy-6-Methylflavone and General Anaesthetics at beta3gamma2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries
    • Chua, H. C., Absalom, N. L., Hanrahan, J. R., Viswas, R. & Chebib, M. The Direct Actions of GABA, 2?-Methoxy-6-Methylflavone and General Anaesthetics at beta3gamma2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries. PloS one 10, e0141359 (2015).
    • (2015) PloS One , vol.10 , pp. e0141359
    • Chua, H.C.1    Absalom, N.L.2    Hanrahan, J.R.3    Viswas, R.4    Chebib, M.5
  • 37
    • 65549134277 scopus 로고    scopus 로고
    • Unanticipated structural and functional properties of δ-subunit-containing GABAA receptors
    • Kaur, K. H., Baur, R. & Sigel, E. Unanticipated structural and functional properties of δ-subunit-containing GABAA receptors. J Biol Chem 284, 7889-7896 (2009).
    • (2009) J Biol Chem , vol.284 , pp. 7889-7896
    • Kaur, K.H.1    Baur, R.2    Sigel, E.3
  • 38
    • 44849114405 scopus 로고    scopus 로고
    • Histamine action on vertebrate GABAA receptors: Direct channel gating and potentiation of GABA responses
    • Saras, A. et al. Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J Biol Chem 283, 10470-10475 (2008).
    • (2008) J Biol Chem , vol.283 , pp. 10470-10475
    • Saras, A.1
  • 39
    • 84969640950 scopus 로고    scopus 로고
    • Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular beta3 + beta3-interface of homooligomeric beta3 GABA receptors
    • Hoerbelt, P. et al. Mutagenesis and computational docking studies support the existence of a histamine binding site at the extracellular beta3 + beta3-interface of homooligomeric beta3 GABA receptors. Neuropharmacol 108, 252-263 (2016).
    • (2016) Neuropharmacol , vol.108 , pp. 252-263
    • Hoerbelt, P.1
  • 40
    • 0037381063 scopus 로고    scopus 로고
    • Zinc-mediated inhibition of GABAA receptors: Discrete binding sites underlie subtype specificity
    • Hosie, A. M., Dunne, E. L., Harvey, R. J. & Smart, T. G. Zinc-mediated inhibition of GABAA receptors: discrete binding sites underlie subtype specificity. Nat. Neurosci. 6, 362-369 (2003).
    • (2003) Nat. Neurosci , vol.6 , pp. 362-369
    • Hosie, A.M.1    Dunne, E.L.2    Harvey, R.J.3    Smart, T.G.4
  • 41
    • 0025193448 scopus 로고
    • Gamma-Aminobutyric acid A receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology
    • Pritchett, D. B. & Seeburg, P. H. Gamma-Aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem 54, 1802-1804 (1990).
    • (1990) J Neurochem , vol.54 , pp. 1802-1804
    • Pritchett, D.B.1    Seeburg, P.H.2
  • 42
    • 0028568712 scopus 로고
    • Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor
    • Wieland, H. A. & Luddens, H. Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem 37, 4576-4580 (1994).
    • (1994) J Med Chem , vol.37 , pp. 4576-4580
    • Wieland, H.A.1    Luddens, H.2
  • 43
    • 0035965267 scopus 로고    scopus 로고
    • Subunit arrangement of gamma-Aminobutyric acid type A receptors
    • Baumann, S. W., Baur, R. & Sigel, E. Subunit arrangement of gamma-Aminobutyric acid type A receptors. J Biol Chem 276, 36275-36280 (2001).
    • (2001) J Biol Chem , vol.276 , pp. 36275-36280
    • Baumann, S.W.1    Baur, R.2    Sigel, E.3
  • 44
    • 0025923505 scopus 로고
    • GABAA receptors are differentially sensitive to zinc: Dependence on subunit composition
    • Smart, T. G., Moss, S. J., Xie, X. & Huganir, R. L. GABAA receptors are differentially sensitive to zinc: dependence on subunit composition. Br J Pharmacol 103, 1837-1839 (1991).
    • (1991) Br J Pharmacol , vol.103 , pp. 1837-1839
    • Smart, T.G.1    Moss, S.J.2    Xie, X.3    Huganir, R.L.4
  • 45
    • 33744545500 scopus 로고    scopus 로고
    • Synaptic release of zinc from brain slices: Factors governing release, imaging, and accurate calculation of concentration
    • Frederickson, C. J. et al. Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration. J Neurosci Methods 154, 19-29 (2006).
    • (2006) J Neurosci Methods , vol.154 , pp. 19-29
    • Frederickson, C.J.1
  • 46
    • 33645743410 scopus 로고    scopus 로고
    • Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion
    • Frederickson, C. J. et al. Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion. Experimental neurology 198, 285-293 (2006).
    • (2006) Experimental Neurology , vol.198 , pp. 285-293
    • Frederickson, C.J.1
  • 47
    • 23744479641 scopus 로고    scopus 로고
    • Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse
    • Qian, J. & Noebels, J. L. Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse. J Physiol 566, 747-758 (2005).
    • (2005) J Physiol , vol.566 , pp. 747-758
    • Qian, J.1    Noebels, J.L.2
  • 48
    • 0033712121 scopus 로고    scopus 로고
    • The actions of synaptically released zinc at hippocampal mossy fiber synapses
    • Vogt, K., Mellor, J., Tong, G. & Nicoll, R. The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron 26, 187-196 (2000).
    • (2000) Neuron , vol.26 , pp. 187-196
    • Vogt, K.1    Mellor, J.2    Tong, G.3    Nicoll, R.4
  • 49
    • 84954342115 scopus 로고    scopus 로고
    • Context-Dependent Modulation of GABAAR-Mediated Tonic Currents
    • Patel, B., Bright, D. P., Mortensen, M., Frolund, B. & Smart, T. G. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurosci 36, 607-621 (2016).
    • (2016) J Neurosci , vol.36 , pp. 607-621
    • Patel, B.1    Bright, D.P.2    Mortensen, M.3    Frolund, B.4    Smart, T.G.5
  • 50
    • 71549172835 scopus 로고    scopus 로고
    • Enhanced tonic GABAA inhibition in typical absence epilepsy
    • Cope, D. W. et al. Enhanced tonic GABAA inhibition in typical absence epilepsy. Nature medicine 15, 1392-1398 (2009).
    • (2009) Nature Medicine , vol.15 , pp. 1392-1398
    • Cope, D.W.1
  • 51
    • 2542457485 scopus 로고    scopus 로고
    • Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit
    • Cope, D. W. et al. Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit. Neuropharmacol 47, 17-34 (2004).
    • (2004) Neuropharmacol , vol.47 , pp. 17-34
    • Cope, D.W.1
  • 52
    • 42749093047 scopus 로고    scopus 로고
    • Expression of GABAA receptor alpha1 subunit mRNA and protein in rat neocortex following photothrombotic infarction
    • Kharlamov, E. A., Downey, K. L., Jukkola, P. I., Grayson, D. R. & Kelly, K. M. Expression of GABAA receptor alpha1 subunit mRNA and protein in rat neocortex following photothrombotic infarction. Brain Res 1210, 29-38 (2008).
    • (2008) Brain Res , vol.1210 , pp. 29-38
    • Kharlamov, E.A.1    Downey, K.L.2    Jukkola, P.I.3    Grayson, D.R.4    Kelly, K.M.5
  • 53
    • 0036890679 scopus 로고    scopus 로고
    • Quantitative reverse transcription-polymerase chain reaction of GABAA alpha1, beta1 and gamma2S subunits in epileptic rats following photothrombotic infarction of neocortex
    • Liu, J. et al. Quantitative reverse transcription-polymerase chain reaction of GABAA alpha1, beta1 and gamma2S subunits in epileptic rats following photothrombotic infarction of neocortex. Epilepsy Res 52, 85-95 (2002).
    • (2002) Epilepsy Res , vol.52 , pp. 85-95
    • Liu, J.1
  • 54
    • 84977071786 scopus 로고    scopus 로고
    • Enhanced phasic GABA inhibition during the repair phase of stroke: A novel therapeutic target
    • Hiu, T. et al. Enhanced phasic GABA inhibition during the repair phase of stroke: A novel therapeutic target. Brain 139 (Pt 2), 468-80 (2016).
    • (2016) Brain , vol.139 , pp. 468-480
    • Hiu, T.1
  • 55
    • 33750941236 scopus 로고    scopus 로고
    • Enhancing GABAA receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy
    • Raol, Y. H. et al. Enhancing GABAA receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci 26, 11342-11346 (2006).
    • (2006) J Neurosci , vol.26 , pp. 11342-11346
    • Raol, Y.H.1
  • 56
    • 33749670677 scopus 로고    scopus 로고
    • Increased GABAA-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus
    • Raol, Y. H. et al. Increased GABAA-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus. Epilepsia 47, 1665-1673 (2006).
    • (2006) Epilepsia , vol.47 , pp. 1665-1673
    • Raol, Y.H.1
  • 57
    • 1342268092 scopus 로고    scopus 로고
    • Transient improvement of aphasia with zolpidem
    • Cohen, L., Chaaban, B. & Habert, M. O. Transient improvement of aphasia with zolpidem. New Eng J Med 350, 949-950 (2004).
    • (2004) New Eng J Med , vol.350 , pp. 949-950
    • Cohen, L.1    Chaaban, B.2    Habert, M.O.3
  • 58
    • 34547803092 scopus 로고    scopus 로고
    • Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy
    • Brefel-Courbon, C. et al. Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy. Ann Neurol 62, 102-105 (2007).
    • (2007) Ann Neurol , vol.62 , pp. 102-105
    • Brefel-Courbon, C.1
  • 59
    • 0036405252 scopus 로고    scopus 로고
    • Cerebral blood perfusion after treatment with zolpidem and flumazenil in the baboon
    • Clauss, R. P. et al. Cerebral blood perfusion after treatment with zolpidem and flumazenil in the baboon. Arzneimittel-Forschung 52, 740-744 (2002).
    • (2002) Arzneimittel-Forschung , vol.52 , pp. 740-744
    • Clauss, R.P.1
  • 60
    • 80555136104 scopus 로고    scopus 로고
    • 2?-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABAA receptors
    • Karim, N. et al. 2?-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABAA receptors. Br J Pharmacol 165, 880-896 (2012).
    • (2012) Br J Pharmacol , vol.165 , pp. 880-896
    • Karim, N.1
  • 61
    • 80555150631 scopus 로고    scopus 로고
    • 3-Hydroxy-2?-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABAA receptor subtypes
    • Karim, N. et al. 3-Hydroxy-2?-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABAA receptor subtypes. Biochem Pharmacol 82, 1971-1983 (2011).
    • (2011) Biochem Pharmacol , vol.82 , pp. 1971-1983
    • Karim, N.1


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