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Volumn 11, Issue 6, 2016, Pages

Sodium-glucose cotransporter 2 inhibitor and a low carbohydrate diet affect gluconeogenesis and glycogen content differently in the kidney and the liver of non-diabetic mice

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; GLYCOGEN; INSULIN; IPRAGLIFLOZIN; TRANSCRIPTION FACTOR FKHR; FATTY ACID SYNTHASE; FOXO1 PROTEIN, MOUSE; GLUCOSIDE; MESSENGER RNA; SODIUM GLUCOSE COTRANSPORTER 2; THIOPHENE DERIVATIVE; TRIACYLGLYCEROL;

EID: 84976904194     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0157672     Document Type: Article
Times cited : (21)

References (46)
  • 1
    • 84884903447 scopus 로고    scopus 로고
    • Carbohydrate nutrition and development of adiposity during adolescence
    • PMID: 23519919.
    • Gopinath B, Flood VM, Rochtchina E, Baur LA, Louie JC, Smith W, et al. Carbohydrate nutrition and development of adiposity during adolescence. Obesity (Silver Spring). 2013; 21(9):1884-90. doi: 10. 1002/oby.20405 PMID: 23519919.
    • (2013) Obesity (Silver Spring) , vol.21 , Issue.9 , pp. 1884-1890
    • Gopinath, B.1    Flood, V.M.2    Rochtchina, E.3    Baur, L.A.4    Louie, J.C.5    Smith, W.6
  • 2
    • 0028232605 scopus 로고
    • Hyperinsulinemic obesity and carbohydrate addiction: The missing link is the carbohydrate frequency factor
    • PMID: 7935072.
    • Heller RF, Heller RF. Hyperinsulinemic obesity and carbohydrate addiction: the missing link is the carbohydrate frequency factor. Med Hypotheses. 1994; 42(5):307-12. PMID: 7935072.
    • (1994) Med Hypotheses , vol.42 , Issue.5 , pp. 307-312
    • Heller, R.F.1    Heller, R.F.2
  • 3
    • 84925354868 scopus 로고    scopus 로고
    • Excess intake of fat and sugar potentiates epinephrine-induced hyperglycemia in male rats
    • PMID: 25716573.
    • Ross AP, Darling JN, Parent MB. Excess intake of fat and sugar potentiates epinephrine-induced hyperglycemia in male rats. J Diabetes Complications. 2015; 29(3):329-37. doi: 10.1016/j.jdiacomp. 2014.12.017 PMID: 25716573.
    • (2015) J Diabetes Complications , vol.29 , Issue.3 , pp. 329-337
    • Ross, A.P.1    Darling, J.N.2    Parent, M.B.3
  • 4
    • 84922749828 scopus 로고    scopus 로고
    • Sugar-induced aging: The deleterious effects of excess dietary sugar intake
    • PMID: 25658934.
    • Ross SM. Sugar-induced aging: the deleterious effects of excess dietary sugar intake. Holist Nurs Pract. 2015; 29(2):114-6. doi: 10.1097/HNP.0000000000000080 PMID: 25658934.
    • (2015) Holist Nurs Pract , vol.29 , Issue.2 , pp. 114-116
    • Ross, S.M.1
  • 5
    • 84917672017 scopus 로고    scopus 로고
    • Cardiovascular disease mortality: The deleterious effects of excess dietary sugar intake
    • PMID: 25470481.
    • Ross SM. Cardiovascular disease mortality: the deleterious effects of excess dietary sugar intake. Holist Nurs Pract. 2015; 29(1):53-7. doi: 10.1097/HNP.0000000000000066 PMID: 25470481.
    • (2015) Holist Nurs Pract , vol.29 , Issue.1 , pp. 53-57
    • Ross, S.M.1
  • 6
    • 84856672309 scopus 로고    scopus 로고
    • Overweight and obesity as risk factors in hypertension-study of the working population
    • PMID: 22332488.
    • Maniecka-Bryla I, Szymocha M, Bryla M. Overweight and obesity as risk factors in hypertension-study of the working population. Med Lav. 2011; 102(6):523-38. PMID: 22332488.
    • (2011) Med Lav , vol.102 , Issue.6 , pp. 523-538
    • Maniecka-Bryla, I.1    Szymocha, M.2    Bryla, M.3
  • 8
    • 65549109680 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: Risk factor, paradox, and impact of weight loss
    • PMID: 19460605
    • Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol. 2009; 53(21):1925-32. doi: 10.1016/j.jacc.2008.12.068 PMID: 19460605.
    • (2009) J Am Coll Cardiol , vol.53 , Issue.21 , pp. 1925-1932
    • Lavie, C.J.1    Milani, R.V.2    Ventura, H.O.3
  • 9
    • 84982682797 scopus 로고    scopus 로고
    • The Effects of a Low-Carbohydrate Diet vs a Low-Fat Diet on Novel Cardiovascular Risk Factors: A Randomized Controlled Trial
    • PMID: 26393645; PubMed Central PMCID: PMCPMC4586572
    • Hu T, Yao L, Reynolds K, Whelton PK, Niu T, Li S, et al. The Effects of a Low-Carbohydrate Diet vs. a Low-Fat Diet on Novel Cardiovascular Risk Factors: A Randomized Controlled Trial. Nutrients. 2015; 7 (9):7978-94. doi: 10.3390/nu7095377 PMID: 26393645; PubMed Central PMCID: PMCPMC4586572.
    • (2015) Nutrients , vol.7 , Issue.9 , pp. 7978-7994
    • Hu, T.1    Yao, L.2    Reynolds, K.3    Whelton, P.K.4    Niu, T.5    Li, S.6
  • 10
    • 84979526649 scopus 로고    scopus 로고
    • Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men
    • PMID: 26421667.
    • Caminhotto Rde O, Fonseca FL, Castro NC, Arantes JP, Sertie RA. Atkins diet program rapidly decreases atherogenic index of plasma in trained adapted overweight men. Arch Endocrinol Metab. 2015; 59(6):568-71. doi: 10.1590/2359-3997000000106 PMID: 26421667.
    • (2015) Arch Endocrinol Metab , vol.59 , Issue.6 , pp. 568-571
    • Caminhotto Rde, O.1    Fonseca, F.L.2    Castro, N.C.3    Arantes, J.P.4    Sertie, R.A.5
  • 11
    • 70349772150 scopus 로고    scopus 로고
    • Therapeutic role of low-carbohydrate ketogenic diet in diabetes
    • PMID: 19818281.
    • Al-Khalifa A, Mathew TC, Al-Zaid NS, Mathew E, Dashti HM. Therapeutic role of low-carbohydrate ketogenic diet in diabetes. Nutrition. 2009; 25(11-12):1177-85. doi: 10.1016/j.nut.2009.04.004 PMID: 19818281.
    • (2009) Nutrition , vol.25 , Issue.11-12 , pp. 1177-1185
    • Al-Khalifa, A.1    Mathew, T.C.2    Al-Zaid, N.S.3    Mathew, E.4    Dashti, H.M.5
  • 12
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • PMID: 22355316; PubMed Central PMCID: PMCPMC3280264
    • Liang Y, Arakawa K, Ueta K, Matsushita Y, Kuriyama C, Martin T, et al. Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One. 2012; 7(2):e30555. doi: 10.1371/journal.pone.0030555 PMID: 22355316; PubMed Central PMCID: PMCPMC3280264.
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e30555
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3    Matsushita, Y.4    Kuriyama, C.5    Martin, T.6
  • 13
    • 84892479365 scopus 로고    scopus 로고
    • Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • PMID: 23906445.
    • Bolinder J, Ljunggren O, Johansson L, Wilding J, Langkilde AM, Sjostrom CD, et al. Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab. 2014; 16(2):159-69. doi: 10.1111/dom.12189 PMID: 23906445.
    • (2014) Diabetes Obes Metab , vol.16 , Issue.2 , pp. 159-169
    • Bolinder, J.1    Ljunggren, O.2    Johansson, L.3    Wilding, J.4    Langkilde, A.M.5    Sjostrom, C.D.6
  • 14
    • 84942258962 scopus 로고    scopus 로고
    • A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus
    • PMID: 26179482
    • Ikeda S, Takano Y, Cynshi O, Tanaka R, Christ AD, Boerlin V, et al. A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2015; 17(10):984-93. doi: 10.1111/dom.12538 PMID: 26179482.
    • (2015) Diabetes Obes Metab , vol.17 , Issue.10 , pp. 984-993
    • Ikeda, S.1    Takano, Y.2    Cynshi, O.3    Tanaka, R.4    Christ, A.D.5    Boerlin, V.6
  • 15
    • 84976903491 scopus 로고    scopus 로고
    • Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Metabolic Parameters in Patients With Type 2 Diabetes: A Chart-Based Analysis
    • PMID: 26858798; PubMed Central PMCID: PMCPMC4737036
    • Katsuyama H, Hamasaki H, Adachi H, Moriyama S, Kawaguchi A, Sako A, et al. Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Metabolic Parameters in Patients With Type 2 Diabetes: A Chart-Based Analysis. J Clin Med Res. 2016; 8(3):237-43. doi: 10.14740/jocmr2467w PMID: 26858798; PubMed Central PMCID: PMCPMC4737036.
    • (2016) J Clin Med Res , vol.8 , Issue.3 , pp. 237-243
    • Katsuyama, H.1    Hamasaki, H.2    Adachi, H.3    Moriyama, S.4    Kawaguchi, A.5    Sako, A.6
  • 16
    • 80052362968 scopus 로고    scopus 로고
    • Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    • PMID: 21606218.
    • Abdul-Ghani MA, Norton L, Defronzo RA. Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev. 2011; 32(4):515-31. doi: 10.1210/er.2010-0029 PMID: 21606218.
    • (2011) Endocr Rev , vol.32 , Issue.4 , pp. 515-531
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 17
    • 84898990696 scopus 로고    scopus 로고
    • Dapagliflozin: Glucuretic action and beyond
    • PMID: 24705156.
    • Balakumar P, Sundram K, Dhanaraj SA. Dapagliflozin: glucuretic action and beyond. Pharmacol Res. 2014; 82:34-9. doi: 10.1016/j.phrs.2014.03.008 PMID: 24705156.
    • (2014) Pharmacol Res , vol.82 , pp. 34-39
    • Balakumar, P.1    Sundram, K.2    Dhanaraj, S.A.3
  • 18
    • 84885476895 scopus 로고    scopus 로고
    • Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice
    • PMID: 23707905.
    • Tahara A, Kurosaki E, Yokono M, Yamajuku D, Kihara R, Hayashizaki Y, et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur J Pharmacol. 2013; 715(1-3):246-55. doi: 10.1016/j. ejphar.2013.05.014 PMID: 23707905.
    • (2013) Eur J Pharmacol , vol.715 , Issue.1-3 , pp. 246-255
    • Tahara, A.1    Kurosaki, E.2    Yokono, M.3    Yamajuku, D.4    Kihara, R.5    Hayashizaki, Y.6
  • 19
    • 0014998945 scopus 로고
    • The staining of glycogen with Best's Carmine and similar hydrogen bonding dyes. A mechanistic study
    • PMID: 4106594.
    • Horobin RW, Murgatroyd LB. The staining of glycogen with Best's Carmine and similar hydrogen bonding dyes. A mechanistic study. Histochem J. 1971; 3(1):1-9. PMID: 4106594.
    • (1971) Histochem J , vol.3 , Issue.1 , pp. 1-9
    • Horobin, R.W.1    Murgatroyd, L.B.2
  • 20
    • 84864371186 scopus 로고    scopus 로고
    • Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats
    • PMID: 22402735.
    • Devenny JJ, Godonis HE, Harvey SJ, Rooney S, Cullen MJ, Pelleymounter MA. Weight loss induced by chronic dapagliflozin treatment is attenuated by compensatory hyperphagia in diet-induced obese (DIO) rats. Obesity (Silver Spring). 2012; 20(8):1645-52. doi: 10.1038/oby.2012.59 PMID: 22402735.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.8 , pp. 1645-1652
    • Devenny, J.J.1    Godonis, H.E.2    Harvey, S.J.3    Rooney, S.4    Cullen, M.J.5    Pelleymounter, M.A.6
  • 21
    • 84937525356 scopus 로고    scopus 로고
    • A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans
    • PMID: 26108304
    • Michel MC, Mayoux E, Vallon V. A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans. Naunyn Schmiedebergs Arch Pharmacol. 2015; 388 (8):801-16. doi: 10.1007/s00210-015-1134-1 PMID: 26108304.
    • (2015) Naunyn Schmiedebergs Arch Pharmacol , vol.388 , Issue.8 , pp. 801-816
    • Michel, M.C.1    Mayoux, E.2    Vallon, V.3
  • 22
    • 33845516690 scopus 로고    scopus 로고
    • Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing
    • PMID: 17130483; PubMed Central PMCID: PMCPMC1948974
    • O'Malley D, Reimann F, Simpson AK, Gribble FM. Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing. Diabetes. 2006; 55(12):3381-6. doi: 10.2337/db06-0531 PMID: 17130483; PubMed Central PMCID: PMCPMC1948974.
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3381-3386
    • O'Malley, D.1    Reimann, F.2    Simpson, A.K.3    Gribble, F.M.4
  • 23
    • 78649678170 scopus 로고    scopus 로고
    • Functional expression of SGLTs in rat brain
    • PMID: 20826762; PubMed Central PMCID: PMCPMC3006325
    • Yu AS, Hirayama BA, Timbol G, Liu J, Basarah E, Kepe V, et al. Functional expression of SGLTs in rat brain. Am J Physiol Cell Physiol. 2010; 299(6):C1277-84. doi: 10.1152/ajpcell.00296.2010 PMID: 20826762; PubMed Central PMCID: PMCPMC3006325.
    • (2010) Am J Physiol Cell Physiol , vol.299 , Issue.6 , pp. C1277-C1284
    • Yu, A.S.1    Hirayama, B.A.2    Timbol, G.3    Liu, J.4    Basarah, E.5    Kepe, V.6
  • 24
    • 84873336411 scopus 로고    scopus 로고
    • Regional distribution of SGLT activity in rat brain in vivo
    • PMID: 23151803; PubMed Central PMCID: PMCPMC3566441
    • Yu AS, Hirayama BA, Timbol G, Liu J, Diez-Sampedro A, Kepe V, et al. Regional distribution of SGLT activity in rat brain in vivo. Am J Physiol Cell Physiol. 2013; 304(3):C240-7. doi: 10.1152/ajpcell.00317.2012 PMID: 23151803; PubMed Central PMCID: PMCPMC3566441.
    • (2013) Am J Physiol Cell Physiol , vol.304 , Issue.3 , pp. C240-C247
    • Yu, A.S.1    Hirayama, B.A.2    Timbol, G.3    Liu, J.4    Diez-Sampedro, A.5    Kepe, V.6
  • 25
    • 84861536065 scopus 로고    scopus 로고
    • Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice
    • PMID: 22410641
    • Suzuki M, Honda K, Fukazawa M, Ozawa K, Hagita H, Kawai T, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012; 341(3):692-701. doi: 10.1124/jpet.112.191593 PMID: 22410641.
    • (2012) J Pharmacol Exp Ther , vol.341 , Issue.3 , pp. 692-701
    • Suzuki, M.1    Honda, K.2    Fukazawa, M.3    Ozawa, K.4    Hagita, H.5    Kawai, T.6
  • 26
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • PMID: 24463454; PubMed Central PMCID: PMCPMC3904627
    • Ferrannini E, Muscelli E, Frascerra S, Baldi S, Mari A, Heise T, et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest. 2014; 124(2):499-508. doi: 10. 1172/JCI72227 PMID: 24463454; PubMed Central PMCID: PMCPMC3904627.
    • (2014) J Clin Invest , vol.124 , Issue.2 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3    Baldi, S.4    Mari, A.5    Heise, T.6
  • 27
    • 84960517126 scopus 로고    scopus 로고
    • Tofogliflozin improves insulin resistance in skeletal muscle and accelerates lipolysis in adipose tissue in male mice
    • PMID: 26713783
    • Obata A, Kubota N, Kubota T, Iwamoto M, Sato H, Sakurai Y, et al. Tofogliflozin Improves Insulin Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice. Endocrinology. 2015:en20151588. doi: 10.1210/en.2015-1588 PMID: 26713783.
    • (2015) Endocrinology , pp. en20151588
    • Obata, A.1    Kubota, N.2    Kubota, T.3    Iwamoto, M.4    Sato, H.5    Sakurai, Y.6
  • 28
    • 84959511891 scopus 로고    scopus 로고
    • The SGLT2 inhibitor empagliflozin improves insulin sensitivity in db/db mice both as monotherapy and in combination with linagliptin
    • PMID: 26773934.
    • Kern M, Kloting N, Mark M, Mayoux E, Klein T, Bluher M. The SGLT2 inhibitor empagliflozin improves insulin sensitivity in db/db mice both as monotherapy and in combination with linagliptin. Metabolism. 2016; 65(2):114-23. doi: 10.1016/j.metabol.2015.10.010 PMID: 26773934.
    • (2016) Metabolism , vol.65 , Issue.2 , pp. 114-123
    • Kern, M.1    Kloting, N.2    Mark, M.3    Mayoux, E.4    Klein, T.5    Bluher, M.6
  • 29
    • 84929517145 scopus 로고    scopus 로고
    • Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice
    • PMID: 25170869 PubMed Central PMCID: PMCPMC4149431
    • Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K, et al. Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice. PLoS One. 2014; 9(8):e104948. doi: 10. 1371/journal.pone.0104948 PMID: 25170869; PubMed Central PMCID: PMCPMC4149431.
    • (2014) PLoS One , vol.9 , Issue.8 , pp. e104948
    • Handa, K.1    Inukai, K.2    Onuma, H.3    Kudo, A.4    Nakagawa, F.5    Tsugawa, K.6
  • 30
    • 0023511457 scopus 로고
    • Fatty liver in rats induced by excessive intake of a nutritionally adequate liquid diet
    • PMID: 3440681.
    • Nomura F, Ohnishi K, Suzuki T, Tanaka H, Tsunoda T, Tanabe Y, et al. Fatty liver in rats induced by excessive intake of a nutritionally adequate liquid diet. Int J Obes. 1987; 11(6):603-8. PMID: 3440681.
    • (1987) Int J Obes , vol.11 , Issue.6 , pp. 603-608
    • Nomura, F.1    Ohnishi, K.2    Suzuki, T.3    Tanaka, H.4    Tsunoda, T.5    Tanabe, Y.6
  • 31
    • 0031750189 scopus 로고    scopus 로고
    • High-monounsaturated fat diet-induced obesity and diabetes in C57BL/6J mice
    • PMID: 9627373.
    • Tsunoda N, Ikemoto S, Takahashi M, Maruyama K, Watanabe H, Goto N, et al. High-monounsaturated fat diet-induced obesity and diabetes in C57BL/6J mice. Metabolism. 1998; 47(6):724-30. PMID: 9627373.
    • (1998) Metabolism , vol.47 , Issue.6 , pp. 724-730
    • Tsunoda, N.1    Ikemoto, S.2    Takahashi, M.3    Maruyama, K.4    Watanabe, H.5    Goto, N.6
  • 32
    • 84913591512 scopus 로고    scopus 로고
    • The influence of dietary fat on liver fat accumulation
    • PMID: 25389901; PubMed Central PMCID: PMCPMC4245577
    • Green CJ, Hodson L. The influence of dietary fat on liver fat accumulation. Nutrients. 2014; 6 (11):5018-33. doi: 10.3390/nu6115018 PMID: 25389901; PubMed Central PMCID: PMCPMC4245577.
    • (2014) Nutrients , vol.6 , Issue.11 , pp. 5018-5033
    • Green, C.J.1    Hodson, L.2
  • 33
    • 84961615237 scopus 로고    scopus 로고
    • Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction
    • PMID: 26977813; PubMed Central PMCID: PMCPMC4792392
    • Komiya C, Tsuchiya K, Shiba K, Miyachi Y, Furuke S, Shimazu N, et al. Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction. PLoS One. 2016; 11(3):e0151511. doi: 10.1371/journal.pone.0151511 PMID: 26977813; PubMed Central PMCID: PMCPMC4792392.
    • (2016) PLoS One , vol.11 , Issue.3 , pp. e0151511
    • Komiya, C.1    Tsuchiya, K.2    Shiba, K.3    Miyachi, Y.4    Furuke, S.5    Shimazu, N.6
  • 34
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • PMID: 24463448; PubMed Central PMCID: PMCPMC3904617
    • Merovci A, Solis-Herrera C, Daniele G, Eldor R, Fiorentino TV, Tripathy D, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest. 2014; 124 (2):509-14. doi: 10.1172/JCI70704 PMID: 24463448; PubMed Central PMCID: PMCPMC3904617.
    • (2014) J Clin Invest , vol.124 , Issue.2 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3    Eldor, R.4    Fiorentino, T.V.5    Tripathy, D.6
  • 35
    • 84937763347 scopus 로고    scopus 로고
    • Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
    • PMID: 25894829.
    • Bonner C, Kerr-Conte J, Gmyr V, Queniat G, Moerman E, Thevenet J, et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med. 2015; 21(5):512-7. doi: 10.1038/nm.3828 PMID: 25894829.
    • (2015) Nat Med , vol.21 , Issue.5 , pp. 512-517
    • Bonner, C.1    Kerr-Conte, J.2    Gmyr, V.3    Queniat, G.4    Moerman, E.5    Thevenet, J.6
  • 36
    • 0028872833 scopus 로고
    • Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine
    • PMID: 7593645; PubMed Central PMCID: PMCPMC185914
    • Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J. Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine. J Clin Invest. 1995; 96 (5):2528-33. doi: 10.1172/JCI118314 PMID: 7593645; PubMed Central PMCID: PMCPMC185914.
    • (1995) J Clin Invest , vol.96 , Issue.5 , pp. 2528-2533
    • Stumvoll, M.1    Chintalapudi, U.2    Perriello, G.3    Welle, S.4    Gutierrez, O.5    Gerich, J.6
  • 37
    • 84892588641 scopus 로고    scopus 로고
    • SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice
    • PMID: 24226524; PubMed Central PMCID: PMCPMC3920018
    • Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, et al. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol. 2014; 306(2):F194-204. doi: 10. 1152/ajprenal.00520.2013 PMID: 24226524; PubMed Central PMCID: PMCPMC3920018.
    • (2014) Am J Physiol Renal Physiol , vol.306 , Issue.2 , pp. F194-F204
    • Vallon, V.1    Gerasimova, M.2    Rose, M.A.3    Masuda, T.4    Satriano, J.5    Mayoux, E.6
  • 38
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    • PMID: 12754525.
    • Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003; 423(6939):550-5. doi: 10.1038/ nature01667 PMID: 12754525.
    • (2003) Nature , vol.423 , Issue.6939 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3    Walkey, C.J.4    Yoon, J.C.5    Oriente, F.6
  • 39
    • 0035855905 scopus 로고    scopus 로고
    • CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
    • PMID: 11557984
    • Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001; 413(6852):179-83. doi: 10.1038/35093131 PMID: 11557984.
    • (2001) Nature , vol.413 , Issue.6852 , pp. 179-183
    • Herzig, S.1    Long, F.2    Jhala, U.S.3    Hedrick, S.4    Quinn, R.5    Bauer, A.6
  • 40
  • 41
    • 0022521185 scopus 로고
    • Renal substrate metabolism
    • PMID: 2938198.
    • Wirthensohn G, Guder WG. Renal substrate metabolism. Physiol Rev. 1986; 66(2):469-97. PMID: 2938198.
    • (1986) Physiol Rev , vol.66 , Issue.2 , pp. 469-497
    • Wirthensohn, G.1    Guder, W.G.2
  • 42
    • 0035146344 scopus 로고    scopus 로고
    • Renal gluconeogenesis: Its importance in human glucose homeostasis
    • PMID: 11213896.
    • Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care. 2001; 24(2):382-91. PMID: 11213896.
    • (2001) Diabetes Care , vol.24 , Issue.2 , pp. 382-391
    • Gerich, J.E.1    Meyer, C.2    Woerle, H.J.3    Stumvoll, M.4
  • 43
    • 84890166010 scopus 로고    scopus 로고
    • Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization
    • Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, et al. Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nat Commun. 2013; 4:2316.
    • (2013) Nat Commun , vol.4 , pp. 2316
    • Izumida, Y.1    Yahagi, N.2    Takeuchi, Y.3    Nishi, M.4    Shikama, A.5    Takarada, A.6
  • 44
    • 84976909714 scopus 로고    scopus 로고
    • PMID: 23939267 PubMed Central PMCID: PMCPMC3753545
    • doi: 10.1038/ncomms3316 PMID: 23939267; PubMed Central PMCID: PMCPMC3753545.
  • 45
    • 35848941694 scopus 로고    scopus 로고
    • Renal carcinogenesis in models of diabetes in rats: Metabolic changes are closely related to neoplastic development
    • PMID: 17952403
    • Dombrowski F, Klotz L, Bannasch P, Evert M. Renal carcinogenesis in models of diabetes in rats: metabolic changes are closely related to neoplastic development. Diabetologia. 2007; 50(12):2580-90. doi: 10.1007/s00125-007-0838-2 PMID: 17952403.
    • (2007) Diabetologia , vol.50 , Issue.12 , pp. 2580-2590
    • Dombrowski, F.1    Klotz, L.2    Bannasch, P.3    Evert, M.4
  • 46
    • 0001359534 scopus 로고
    • The pathology of Armanni-Ebstein diabetic nephropathy
    • PMID: 13478656; PubMed Central PMCID: PMCPMC1934668
    • Ritchie S, Waugh D. The pathology of Armanni-Ebstein diabetic nephropathy. Am J Pathol. 1957; 33 (6):1035-57. PMID: 13478656; PubMed Central PMCID: PMCPMC1934668.
    • (1957) Am J Pathol , vol.33 , Issue.6 , pp. 1035-1057
    • Ritchie, S.1    Waugh, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.